Levan-Capped Silver Nanoparticles for Bactericidal Formulations: Release and Activity Modelling

An environmentally friendly technique was used to produce levan-capped silver nanoparticles of about 30 nm (with a loading of 30%) that showed bactericide effect, for <i>E. coli</i> and <i>B. subtilis</i>. That effect was mathematically studied with a dose-response model (let...

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Main Authors: Álvaro González-Garcinuño, Rubén Masa, María Hernández, Ángel Domínguez, Antonio Tabernero, Eva Martín del Valle
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:International Journal of Molecular Sciences
Subjects:
Online Access:https://www.mdpi.com/1422-0067/20/6/1502
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author Álvaro González-Garcinuño
Rubén Masa
María Hernández
Ángel Domínguez
Antonio Tabernero
Eva Martín del Valle
author_facet Álvaro González-Garcinuño
Rubén Masa
María Hernández
Ángel Domínguez
Antonio Tabernero
Eva Martín del Valle
author_sort Álvaro González-Garcinuño
collection DOAJ
description An environmentally friendly technique was used to produce levan-capped silver nanoparticles of about 30 nm (with a loading of 30%) that showed bactericide effect, for <i>E. coli</i> and <i>B. subtilis</i>. That effect was mathematically studied with a dose-response model (lethal dose of 12.4 ppm and 6.8 ppm respectively). These silver nanoparticles were subsequently introduced in a gel to create a silver release system with bacteria inhibition activity. Silver release from the gel and its bactericidal activity was theoretically studied to develop a unique model that is able to predict accurately both silver release and lethal dose for any type of bacteria. This model will be useful for performing predictions for future silver in gel applications.
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spelling doaj.art-d63948dd2c2140929ace67a398599bcc2022-12-22T03:03:46ZengMDPI AGInternational Journal of Molecular Sciences1422-00672019-03-01206150210.3390/ijms20061502ijms20061502Levan-Capped Silver Nanoparticles for Bactericidal Formulations: Release and Activity ModellingÁlvaro González-Garcinuño0Rubén Masa1María Hernández2Ángel Domínguez3Antonio Tabernero4Eva Martín del Valle5Department of Chemical Engineering, University of Salamanca, 37008 Salamanca, SpainDepartment of Chemical Engineering, University of Salamanca, 37008 Salamanca, SpainDepartment of Chemical Engineering, University of Salamanca, 37008 Salamanca, SpainDepartment of Microbiology and Genetics, University of Salamanca, 37008 Salamanca, SpainDepartment of Chemical Engineering, University of Salamanca, 37008 Salamanca, SpainDepartment of Chemical Engineering, University of Salamanca, 37008 Salamanca, SpainAn environmentally friendly technique was used to produce levan-capped silver nanoparticles of about 30 nm (with a loading of 30%) that showed bactericide effect, for <i>E. coli</i> and <i>B. subtilis</i>. That effect was mathematically studied with a dose-response model (lethal dose of 12.4 ppm and 6.8 ppm respectively). These silver nanoparticles were subsequently introduced in a gel to create a silver release system with bacteria inhibition activity. Silver release from the gel and its bactericidal activity was theoretically studied to develop a unique model that is able to predict accurately both silver release and lethal dose for any type of bacteria. This model will be useful for performing predictions for future silver in gel applications.https://www.mdpi.com/1422-0067/20/6/1502silvernanoparticleslevanmodelling
spellingShingle Álvaro González-Garcinuño
Rubén Masa
María Hernández
Ángel Domínguez
Antonio Tabernero
Eva Martín del Valle
Levan-Capped Silver Nanoparticles for Bactericidal Formulations: Release and Activity Modelling
International Journal of Molecular Sciences
silver
nanoparticles
levan
modelling
title Levan-Capped Silver Nanoparticles for Bactericidal Formulations: Release and Activity Modelling
title_full Levan-Capped Silver Nanoparticles for Bactericidal Formulations: Release and Activity Modelling
title_fullStr Levan-Capped Silver Nanoparticles for Bactericidal Formulations: Release and Activity Modelling
title_full_unstemmed Levan-Capped Silver Nanoparticles for Bactericidal Formulations: Release and Activity Modelling
title_short Levan-Capped Silver Nanoparticles for Bactericidal Formulations: Release and Activity Modelling
title_sort levan capped silver nanoparticles for bactericidal formulations release and activity modelling
topic silver
nanoparticles
levan
modelling
url https://www.mdpi.com/1422-0067/20/6/1502
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AT mariahernandez levancappedsilvernanoparticlesforbactericidalformulationsreleaseandactivitymodelling
AT angeldominguez levancappedsilvernanoparticlesforbactericidalformulationsreleaseandactivitymodelling
AT antoniotabernero levancappedsilvernanoparticlesforbactericidalformulationsreleaseandactivitymodelling
AT evamartindelvalle levancappedsilvernanoparticlesforbactericidalformulationsreleaseandactivitymodelling