Insights on Ferroptosis and Colorectal Cancer: Progress and Updates
Patients with advanced-stage or treatment-resistant colorectal cancer (CRC) benefit less from traditional therapies; hence, new therapeutic strategies may help improve the treatment response and prognosis of these patients. Ferroptosis is an iron-dependent type of regulated cell death characterized...
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| Format: | Article |
| Jezik: | English |
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MDPI AG
2022-12-01
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| Serija: | Molecules |
| Teme: | |
| Online dostop: | https://www.mdpi.com/1420-3049/28/1/243 |
| _version_ | 1827597407284625408 |
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| author | Bangli Hu Yixin Yin Siqi Li Xianwen Guo |
| author_facet | Bangli Hu Yixin Yin Siqi Li Xianwen Guo |
| author_sort | Bangli Hu |
| collection | DOAJ |
| description | Patients with advanced-stage or treatment-resistant colorectal cancer (CRC) benefit less from traditional therapies; hence, new therapeutic strategies may help improve the treatment response and prognosis of these patients. Ferroptosis is an iron-dependent type of regulated cell death characterized by the accumulation of lipid reactive oxygen species (ROS), distinct from other types of regulated cell death. CRC cells, especially those with drug-resistant properties, are characterized by high iron levels and ROS. This indicates that the induction of ferroptosis in these cells may become a new therapeutic approach for CRC, particularly for eradicating CRC resistant to traditional therapies. Recent studies have demonstrated the mechanisms and pathways that trigger or inhibit ferroptosis in CRC, and many regulatory molecules and pathways have been identified. Here, we review the current research progress on the mechanism of ferroptosis, new molecules that mediate ferroptosis, including coding and non-coding RNA; novel inducers and inhibitors of ferroptosis, which are mainly small-molecule compounds; and newly designed nanoparticles that increase the sensitivity of cells to ferroptosis. Finally, the gene signatures and clusters that have predictive value on CRC are summarized. |
| first_indexed | 2024-03-09T03:29:56Z |
| format | Article |
| id | doaj.art-d63b2827ae4d468a89269fd21966f103 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T03:29:56Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-d63b2827ae4d468a89269fd21966f1032023-12-03T14:57:16ZengMDPI AGMolecules1420-30492022-12-0128124310.3390/molecules28010243Insights on Ferroptosis and Colorectal Cancer: Progress and UpdatesBangli Hu0Yixin Yin1Siqi Li2Xianwen Guo3Department of Research, Guangxi Medical University Cancer Hospital, Nanning 530021, ChinaDepartment of Research, Guangxi Medical University Cancer Hospital, Nanning 530021, ChinaDepartment of Research, Guangxi Medical University Cancer Hospital, Nanning 530021, ChinaDepartment of Gastroenterology, The People’s Hospital of Guangxi Zhuang Autonomous Region, Taoyuan Road No.6, Nanning 530021, ChinaPatients with advanced-stage or treatment-resistant colorectal cancer (CRC) benefit less from traditional therapies; hence, new therapeutic strategies may help improve the treatment response and prognosis of these patients. Ferroptosis is an iron-dependent type of regulated cell death characterized by the accumulation of lipid reactive oxygen species (ROS), distinct from other types of regulated cell death. CRC cells, especially those with drug-resistant properties, are characterized by high iron levels and ROS. This indicates that the induction of ferroptosis in these cells may become a new therapeutic approach for CRC, particularly for eradicating CRC resistant to traditional therapies. Recent studies have demonstrated the mechanisms and pathways that trigger or inhibit ferroptosis in CRC, and many regulatory molecules and pathways have been identified. Here, we review the current research progress on the mechanism of ferroptosis, new molecules that mediate ferroptosis, including coding and non-coding RNA; novel inducers and inhibitors of ferroptosis, which are mainly small-molecule compounds; and newly designed nanoparticles that increase the sensitivity of cells to ferroptosis. Finally, the gene signatures and clusters that have predictive value on CRC are summarized.https://www.mdpi.com/1420-3049/28/1/243ferroptosiscolorectal cancermolecularcompoundsnanoparticlessignature |
| spellingShingle | Bangli Hu Yixin Yin Siqi Li Xianwen Guo Insights on Ferroptosis and Colorectal Cancer: Progress and Updates Molecules ferroptosis colorectal cancer molecular compounds nanoparticles signature |
| title | Insights on Ferroptosis and Colorectal Cancer: Progress and Updates |
| title_full | Insights on Ferroptosis and Colorectal Cancer: Progress and Updates |
| title_fullStr | Insights on Ferroptosis and Colorectal Cancer: Progress and Updates |
| title_full_unstemmed | Insights on Ferroptosis and Colorectal Cancer: Progress and Updates |
| title_short | Insights on Ferroptosis and Colorectal Cancer: Progress and Updates |
| title_sort | insights on ferroptosis and colorectal cancer progress and updates |
| topic | ferroptosis colorectal cancer molecular compounds nanoparticles signature |
| url | https://www.mdpi.com/1420-3049/28/1/243 |
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