Racial disparities negatively impact outcomes in early‐onset colorectal cancer independent of socioeconomic status
Abstract Background The incidence of colorectal cancer (CRC) in patients under age 50 is rising for unclear reasons. We examined the effects of socioeconomic factors on outcomes for patients with early‐onset CRC compared to late‐onset CRC. Methods Patients with CRC from 2004 to 2015 in the National...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-11-01
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| Series: | Cancer Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/cam4.4276 |
| _version_ | 1819118284020121600 |
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| author | Suneel D. Kamath Nataly Torrejon Wei Wei Katherine Tullio Kanika G. Nair David Liska Smitha S. Krishnamurthi Alok A. Khorana |
| author_facet | Suneel D. Kamath Nataly Torrejon Wei Wei Katherine Tullio Kanika G. Nair David Liska Smitha S. Krishnamurthi Alok A. Khorana |
| author_sort | Suneel D. Kamath |
| collection | DOAJ |
| description | Abstract Background The incidence of colorectal cancer (CRC) in patients under age 50 is rising for unclear reasons. We examined the effects of socioeconomic factors on outcomes for patients with early‐onset CRC compared to late‐onset CRC. Methods Patients with CRC from 2004 to 2015 in the National Cancer Database were included and categorized by age (under or over 50 years). Differences in demographic and socioeconomic factors, disease characteristics, and survival outcomes between early‐onset versus late‐onset CRC patients were assessed by Chi‐squared test and Cox models. Results The study population included 1,061,204 patients, 108,058 (10.2%) of whom were under age 50. The proportion of patients diagnosed under age 50 increased over time: 9.4% in 2004–2006, 10.1% in 2007–2009, 10.5% in 2010–2012, and 10.7% in 2013–2015 (p < 0.0001). Early‐onset CRC patients were more likely to be Black (15.1% vs. 11.3%) or Hispanic (8.6% vs. 4.6%) and to present with stage 4 disease (24.9% vs. 17.0%), p < 0.0001 for all. Black patients had the worst median OS (58.3 months) compared to White (67.0 months), Hispanic (91.6 months), or Asian (104.9 months) patients, p < 0.0001. Within the subgroup of early‐onset CRC patients with private insurance, Black patients had worse OS compared to White patients, even in communities with higher income and education status. Conclusions Early‐onset CRC continues to increase. Patients with early‐onset CRC are more likely to be Black or Hispanic and to present with stage 4 cancer. Early‐onset Black patients showed worse OS compared to White patients in all income subgroups, even with private insurance. |
| first_indexed | 2024-12-22T05:46:25Z |
| format | Article |
| id | doaj.art-d63e6d7d34a1489791d1439d92f1f3eb |
| institution | Directory Open Access Journal |
| issn | 2045-7634 |
| language | English |
| last_indexed | 2024-12-22T05:46:25Z |
| publishDate | 2021-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj.art-d63e6d7d34a1489791d1439d92f1f3eb2022-12-21T18:37:01ZengWileyCancer Medicine2045-76342021-11-0110217542755010.1002/cam4.4276Racial disparities negatively impact outcomes in early‐onset colorectal cancer independent of socioeconomic statusSuneel D. Kamath0Nataly Torrejon1Wei Wei2Katherine Tullio3Kanika G. Nair4David Liska5Smitha S. Krishnamurthi6Alok A. Khorana7Cleveland Clinic Lerner College of Medicine Cleveland Clinic Taussig Cancer Institute Cleveland Ohio USADepartment of Internal Medicine Cleveland Clinic Foundation Cleveland Ohio USADepartment of Quantitative Health Sciences Cleveland Clinic Cleveland Ohio USACleveland Clinic Lerner College of Medicine Cleveland Clinic Taussig Cancer Institute Cleveland Ohio USACleveland Clinic Lerner College of Medicine Cleveland Clinic Taussig Cancer Institute Cleveland Ohio USADepartment of Internal Medicine Cleveland Clinic Foundation Cleveland Ohio USACleveland Clinic Lerner College of Medicine Cleveland Clinic Taussig Cancer Institute Cleveland Ohio USACleveland Clinic Lerner College of Medicine Cleveland Clinic Taussig Cancer Institute Cleveland Ohio USAAbstract Background The incidence of colorectal cancer (CRC) in patients under age 50 is rising for unclear reasons. We examined the effects of socioeconomic factors on outcomes for patients with early‐onset CRC compared to late‐onset CRC. Methods Patients with CRC from 2004 to 2015 in the National Cancer Database were included and categorized by age (under or over 50 years). Differences in demographic and socioeconomic factors, disease characteristics, and survival outcomes between early‐onset versus late‐onset CRC patients were assessed by Chi‐squared test and Cox models. Results The study population included 1,061,204 patients, 108,058 (10.2%) of whom were under age 50. The proportion of patients diagnosed under age 50 increased over time: 9.4% in 2004–2006, 10.1% in 2007–2009, 10.5% in 2010–2012, and 10.7% in 2013–2015 (p < 0.0001). Early‐onset CRC patients were more likely to be Black (15.1% vs. 11.3%) or Hispanic (8.6% vs. 4.6%) and to present with stage 4 disease (24.9% vs. 17.0%), p < 0.0001 for all. Black patients had the worst median OS (58.3 months) compared to White (67.0 months), Hispanic (91.6 months), or Asian (104.9 months) patients, p < 0.0001. Within the subgroup of early‐onset CRC patients with private insurance, Black patients had worse OS compared to White patients, even in communities with higher income and education status. Conclusions Early‐onset CRC continues to increase. Patients with early‐onset CRC are more likely to be Black or Hispanic and to present with stage 4 cancer. Early‐onset Black patients showed worse OS compared to White patients in all income subgroups, even with private insurance.https://doi.org/10.1002/cam4.4276disparitiesearly‐onset colorectal cancerhealth disparitiesracial disparitiessocial determinants of health |
| spellingShingle | Suneel D. Kamath Nataly Torrejon Wei Wei Katherine Tullio Kanika G. Nair David Liska Smitha S. Krishnamurthi Alok A. Khorana Racial disparities negatively impact outcomes in early‐onset colorectal cancer independent of socioeconomic status Cancer Medicine disparities early‐onset colorectal cancer health disparities racial disparities social determinants of health |
| title | Racial disparities negatively impact outcomes in early‐onset colorectal cancer independent of socioeconomic status |
| title_full | Racial disparities negatively impact outcomes in early‐onset colorectal cancer independent of socioeconomic status |
| title_fullStr | Racial disparities negatively impact outcomes in early‐onset colorectal cancer independent of socioeconomic status |
| title_full_unstemmed | Racial disparities negatively impact outcomes in early‐onset colorectal cancer independent of socioeconomic status |
| title_short | Racial disparities negatively impact outcomes in early‐onset colorectal cancer independent of socioeconomic status |
| title_sort | racial disparities negatively impact outcomes in early onset colorectal cancer independent of socioeconomic status |
| topic | disparities early‐onset colorectal cancer health disparities racial disparities social determinants of health |
| url | https://doi.org/10.1002/cam4.4276 |
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