An experimental model for ovarian cancer: propagation of ovarian cancer initiating cells and generation of ovarian cancer organoids

An experimental model for ovarian cancer: propagation of ovarian cancer initiating cells and generation of ovarian cancer organoids

Abstract Background Ovarian cancer (OC) is the most lethal gynecological cancer due to the recurrence of drug-resistance. Cancer initiating cells (CICs) are proposed to be responsible for the aggressiveness of OC. The rarity and difficulty of in vitro long-term cultivation of CICs challenge the deve...

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Bibliographic Details
Main Authors: Yu-An Chen, Chen-Yu Lu, Wen-Fang Cheng, Kuan-Ting Kuo, Chen-Wei Yu, Hon-Nerng Ho, Hsin-Fu Chen, Szu-Hua Pan
Format: Article
Language:English
Published: BMC 2022-09-01
Series:BMC Cancer
Subjects:
Ovarian cancer (OC)
Cancer-initiating cells (CICs)
Induced ovarian cancer-initiating cells (iOCICs)
Organoid and drug screening
Online Access:https://doi.org/10.1186/s12885-022-10042-3

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