Retraction Note: Transgenic mice overexpressing the ALS-linked protein Matrin 3 develop a profound muscle phenotype
Abstract The authors are retracting this article. The article describes mice expressing wild-type human MATR3. However, since publication the authors have become aware that all of the lines of mice described express human MATR3 containing the F115C mutation. Transgenic mice expressing wild-type and...
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2017-12-01
|
| Series: | Acta Neuropathologica Communications |
| Online Access: | http://link.springer.com/article/10.1186/s40478-017-0502-0 |
| _version_ | 1817978504569946112 |
|---|---|
| author | Christina Moloney Sruti Rayaprolu John Howard Susan Fromholt Hilda Brown Matt Collins Mariela Cabrera Colin Duffy Zoe Siemienski Dave Miller Maurice S. Swanson Lucia Notterpek David R. Borchelt Jada Lewis |
| author_facet | Christina Moloney Sruti Rayaprolu John Howard Susan Fromholt Hilda Brown Matt Collins Mariela Cabrera Colin Duffy Zoe Siemienski Dave Miller Maurice S. Swanson Lucia Notterpek David R. Borchelt Jada Lewis |
| author_sort | Christina Moloney |
| collection | DOAJ |
| description | Abstract The authors are retracting this article. The article describes mice expressing wild-type human MATR3. However, since publication the authors have become aware that all of the lines of mice described express human MATR3 containing the F115C mutation. Transgenic mice expressing wild-type and mutant Matrin were created simultaneously in their laboratory and, at a crucial stage of generating the DNA for embryo injection, as confirmed by an investigation by the University of Florida, the DNA preparations were accidentally mislabelled. All of the founders created were mosaic, requiring extensive breeding to isolate stable lines. Mice mislabelled as expressing wild-type MATR3 were the first to produce lines that stably transmitted the transgene and thus were the first to be characterized. However, as lines of mice that were mislabelled as expressing the mutant (F115C) MATR3 were ultimately established, the data began to suggest that an error had been made. Sequence analysis of amplified tail DNA from mice descended from the lines reported in the article have revealed that they express the F115C variant. The data described are therefore an accurate description of the pathology of mice that express the F115C variant of MATR3, but not of mice expressing wild-type MATR3. The authors are preparing a new manuscript reporting data from both mice expressing the F115C variant of MATR3 and mice expressing wild-type MATR3. |
| first_indexed | 2024-04-13T22:30:09Z |
| format | Article |
| id | doaj.art-d64237b7552645d7a5d2dfd84b751f97 |
| institution | Directory Open Access Journal |
| issn | 2051-5960 |
| language | English |
| last_indexed | 2024-04-13T22:30:09Z |
| publishDate | 2017-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Acta Neuropathologica Communications |
| spelling | doaj.art-d64237b7552645d7a5d2dfd84b751f972022-12-22T02:26:57ZengBMCActa Neuropathologica Communications2051-59602017-12-01511110.1186/s40478-017-0502-0Retraction Note: Transgenic mice overexpressing the ALS-linked protein Matrin 3 develop a profound muscle phenotypeChristina Moloney0Sruti Rayaprolu1John Howard2Susan Fromholt3Hilda Brown4Matt Collins5Mariela Cabrera6Colin Duffy7Zoe Siemienski8Dave Miller9Maurice S. Swanson10Lucia Notterpek11David R. Borchelt12Jada Lewis13Center for Translational Research in Neurodegenerative Disease, University of FloridaCenter for Translational Research in Neurodegenerative Disease, University of FloridaCenter for Translational Research in Neurodegenerative Disease, University of FloridaCenter for Translational Research in Neurodegenerative Disease, University of FloridaCenter for Translational Research in Neurodegenerative Disease, University of FloridaCenter for Translational Research in Neurodegenerative Disease, University of FloridaCenter for Translational Research in Neurodegenerative Disease, University of FloridaCenter for Translational Research in Neurodegenerative Disease, University of FloridaCenter for Translational Research in Neurodegenerative Disease, University of FloridaCenter for Translational Research in Neurodegenerative Disease, University of FloridaDepartment of Molecular Genetics and Microbiology, Center for NeuroGenetics and the Genetics Institute, University of Florida, College of MedicineCenter for Translational Research in Neurodegenerative Disease, University of FloridaCenter for Translational Research in Neurodegenerative Disease, University of FloridaCenter for Translational Research in Neurodegenerative Disease, University of FloridaAbstract The authors are retracting this article. The article describes mice expressing wild-type human MATR3. However, since publication the authors have become aware that all of the lines of mice described express human MATR3 containing the F115C mutation. Transgenic mice expressing wild-type and mutant Matrin were created simultaneously in their laboratory and, at a crucial stage of generating the DNA for embryo injection, as confirmed by an investigation by the University of Florida, the DNA preparations were accidentally mislabelled. All of the founders created were mosaic, requiring extensive breeding to isolate stable lines. Mice mislabelled as expressing wild-type MATR3 were the first to produce lines that stably transmitted the transgene and thus were the first to be characterized. However, as lines of mice that were mislabelled as expressing the mutant (F115C) MATR3 were ultimately established, the data began to suggest that an error had been made. Sequence analysis of amplified tail DNA from mice descended from the lines reported in the article have revealed that they express the F115C variant. The data described are therefore an accurate description of the pathology of mice that express the F115C variant of MATR3, but not of mice expressing wild-type MATR3. The authors are preparing a new manuscript reporting data from both mice expressing the F115C variant of MATR3 and mice expressing wild-type MATR3.http://link.springer.com/article/10.1186/s40478-017-0502-0 |
| spellingShingle | Christina Moloney Sruti Rayaprolu John Howard Susan Fromholt Hilda Brown Matt Collins Mariela Cabrera Colin Duffy Zoe Siemienski Dave Miller Maurice S. Swanson Lucia Notterpek David R. Borchelt Jada Lewis Retraction Note: Transgenic mice overexpressing the ALS-linked protein Matrin 3 develop a profound muscle phenotype Acta Neuropathologica Communications |
| title | Retraction Note: Transgenic mice overexpressing the ALS-linked protein Matrin 3 develop a profound muscle phenotype |
| title_full | Retraction Note: Transgenic mice overexpressing the ALS-linked protein Matrin 3 develop a profound muscle phenotype |
| title_fullStr | Retraction Note: Transgenic mice overexpressing the ALS-linked protein Matrin 3 develop a profound muscle phenotype |
| title_full_unstemmed | Retraction Note: Transgenic mice overexpressing the ALS-linked protein Matrin 3 develop a profound muscle phenotype |
| title_short | Retraction Note: Transgenic mice overexpressing the ALS-linked protein Matrin 3 develop a profound muscle phenotype |
| title_sort | retraction note transgenic mice overexpressing the als linked protein matrin 3 develop a profound muscle phenotype |
| url | http://link.springer.com/article/10.1186/s40478-017-0502-0 |
| work_keys_str_mv | AT christinamoloney retractionnotetransgenicmiceoverexpressingthealslinkedproteinmatrin3developaprofoundmusclephenotype AT srutirayaprolu retractionnotetransgenicmiceoverexpressingthealslinkedproteinmatrin3developaprofoundmusclephenotype AT johnhoward retractionnotetransgenicmiceoverexpressingthealslinkedproteinmatrin3developaprofoundmusclephenotype AT susanfromholt retractionnotetransgenicmiceoverexpressingthealslinkedproteinmatrin3developaprofoundmusclephenotype AT hildabrown retractionnotetransgenicmiceoverexpressingthealslinkedproteinmatrin3developaprofoundmusclephenotype AT mattcollins retractionnotetransgenicmiceoverexpressingthealslinkedproteinmatrin3developaprofoundmusclephenotype AT marielacabrera retractionnotetransgenicmiceoverexpressingthealslinkedproteinmatrin3developaprofoundmusclephenotype AT colinduffy retractionnotetransgenicmiceoverexpressingthealslinkedproteinmatrin3developaprofoundmusclephenotype AT zoesiemienski retractionnotetransgenicmiceoverexpressingthealslinkedproteinmatrin3developaprofoundmusclephenotype AT davemiller retractionnotetransgenicmiceoverexpressingthealslinkedproteinmatrin3developaprofoundmusclephenotype AT mauricesswanson retractionnotetransgenicmiceoverexpressingthealslinkedproteinmatrin3developaprofoundmusclephenotype AT lucianotterpek retractionnotetransgenicmiceoverexpressingthealslinkedproteinmatrin3developaprofoundmusclephenotype AT davidrborchelt retractionnotetransgenicmiceoverexpressingthealslinkedproteinmatrin3developaprofoundmusclephenotype AT jadalewis retractionnotetransgenicmiceoverexpressingthealslinkedproteinmatrin3developaprofoundmusclephenotype |