How Cardiac Fibrosis Assessed via T1 Mapping Is Associated with Liver Fibrosis in Patients with Non-Alcoholic Fatty Liver Disease
(1) Background: Nonalcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases worldwide. Although cardiovascular and NAFLD risk factors overlap, an independent association between these conditions may exist. Hepatic and cardiac fibrosis are important markers of mortality,...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-11-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/23/7381 |
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| author | Flavia Vernin de Oliveira Terzi Gabriel Cordeiro Camargo Daniella Braz Parente Ana Maria Pittella Gilberto Silva-Junior Gabrielle Gonçalves de Novaes Jaime Araújo Oliveira Neto Julia Machado Barroso Martha Valéria Tavares Pinheiro Adriana Soares Xavier de Brito Renée Sarmento de Oliveira Rosana Souza Rodrigues Renata de Mello Perez Andréa Silvestre de Sousa Renata Junqueira Moll-Bernardes |
| author_facet | Flavia Vernin de Oliveira Terzi Gabriel Cordeiro Camargo Daniella Braz Parente Ana Maria Pittella Gilberto Silva-Junior Gabrielle Gonçalves de Novaes Jaime Araújo Oliveira Neto Julia Machado Barroso Martha Valéria Tavares Pinheiro Adriana Soares Xavier de Brito Renée Sarmento de Oliveira Rosana Souza Rodrigues Renata de Mello Perez Andréa Silvestre de Sousa Renata Junqueira Moll-Bernardes |
| author_sort | Flavia Vernin de Oliveira Terzi |
| collection | DOAJ |
| description | (1) Background: Nonalcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases worldwide. Although cardiovascular and NAFLD risk factors overlap, an independent association between these conditions may exist. Hepatic and cardiac fibrosis are important markers of mortality, but the correlation between these markers in patients with NAFLD has not been well studied. Our main objective was to determine the degree of myocardial fibrosis in patients with NAFLD and its correlation with the severity of liver fibrosis. (2) Methods: In this cross-sectional study, patients with NAFLD were allocated to two groups according to the stage of liver fibrosis assessed using MRI: no or mild fibrosis (F0–F1) and significant fibrosis (F2–F4). Framingham risk scores were calculated to evaluate cardiovascular risk factors, and patients underwent multiparametric cardiac and abdominal MRIs. (3) Results: The sample comprised 44 patients (28 with no or mild liver fibrosis and 16 with significant liver fibrosis). The mean age was 57.9 ± 12 years, and 41% were men. Most patients had high cardiac risk factors and carotid disease. Relative to patients with no or mild liver fibrosis, those with significant fibrosis had a higher median calcium score (<i>p</i> = 0.05) and increased myocardial extracellular volume (ECV; <i>p</i> = 0.02). Liver fibrosis correlated with cardiac fibrosis, represented by the ECV (r = 0.49, <i>p</i> < 0.001). The myocardial ECV differentiated patients with and without significant liver fibrosis (AUC = 0.78). (4) Conclusion: This study showed that diffuse myocardial fibrosis is associated with liver fibrosis in patients with NAFLD. |
| first_indexed | 2024-03-09T01:48:20Z |
| format | Article |
| id | doaj.art-d642b807910349368358025d19d81d81 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T01:48:20Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-d642b807910349368358025d19d81d812023-12-08T15:19:42ZengMDPI AGJournal of Clinical Medicine2077-03832023-11-011223738110.3390/jcm12237381How Cardiac Fibrosis Assessed via T1 Mapping Is Associated with Liver Fibrosis in Patients with Non-Alcoholic Fatty Liver DiseaseFlavia Vernin de Oliveira Terzi0Gabriel Cordeiro Camargo1Daniella Braz Parente2Ana Maria Pittella3Gilberto Silva-Junior4Gabrielle Gonçalves de Novaes5Jaime Araújo Oliveira Neto6Julia Machado Barroso7Martha Valéria Tavares Pinheiro8Adriana Soares Xavier de Brito9Renée Sarmento de Oliveira10Rosana Souza Rodrigues11Renata de Mello Perez12Andréa Silvestre de Sousa13Renata Junqueira Moll-Bernardes14D’Or Institute for Research and Education—IDOR, Rio de Janeiro 22281-100, BrazilD’Or Institute for Research and Education—IDOR, Rio de Janeiro 22281-100, BrazilD’Or Institute for Research and Education—IDOR, Rio de Janeiro 22281-100, BrazilD’Or Institute for Research and Education—IDOR, Rio de Janeiro 22281-100, BrazilD’Or Institute for Research and Education—IDOR, Rio de Janeiro 22281-100, BrazilD’Or Institute for Research and Education—IDOR, Rio de Janeiro 22281-100, BrazilD’Or Institute for Research and Education—IDOR, Rio de Janeiro 22281-100, BrazilD’Or Institute for Research and Education—IDOR, Rio de Janeiro 22281-100, BrazilD’Or Institute for Research and Education—IDOR, Rio de Janeiro 22281-100, BrazilD’Or Institute for Research and Education—IDOR, Rio de Janeiro 22281-100, BrazilD’Or Institute for Research and Education—IDOR, Rio de Janeiro 22281-100, BrazilD’Or Institute for Research and Education—IDOR, Rio de Janeiro 22281-100, BrazilD’Or Institute for Research and Education—IDOR, Rio de Janeiro 22281-100, BrazilD’Or Institute for Research and Education—IDOR, Rio de Janeiro 22281-100, BrazilD’Or Institute for Research and Education—IDOR, Rio de Janeiro 22281-100, Brazil(1) Background: Nonalcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases worldwide. Although cardiovascular and NAFLD risk factors overlap, an independent association between these conditions may exist. Hepatic and cardiac fibrosis are important markers of mortality, but the correlation between these markers in patients with NAFLD has not been well studied. Our main objective was to determine the degree of myocardial fibrosis in patients with NAFLD and its correlation with the severity of liver fibrosis. (2) Methods: In this cross-sectional study, patients with NAFLD were allocated to two groups according to the stage of liver fibrosis assessed using MRI: no or mild fibrosis (F0–F1) and significant fibrosis (F2–F4). Framingham risk scores were calculated to evaluate cardiovascular risk factors, and patients underwent multiparametric cardiac and abdominal MRIs. (3) Results: The sample comprised 44 patients (28 with no or mild liver fibrosis and 16 with significant liver fibrosis). The mean age was 57.9 ± 12 years, and 41% were men. Most patients had high cardiac risk factors and carotid disease. Relative to patients with no or mild liver fibrosis, those with significant fibrosis had a higher median calcium score (<i>p</i> = 0.05) and increased myocardial extracellular volume (ECV; <i>p</i> = 0.02). Liver fibrosis correlated with cardiac fibrosis, represented by the ECV (r = 0.49, <i>p</i> < 0.001). The myocardial ECV differentiated patients with and without significant liver fibrosis (AUC = 0.78). (4) Conclusion: This study showed that diffuse myocardial fibrosis is associated with liver fibrosis in patients with NAFLD.https://www.mdpi.com/2077-0383/12/23/7381nonalcoholic fatty liver diseasecardiovascular diseasefibrosismyocardial extracellular volumemagnetic resonance |
| spellingShingle | Flavia Vernin de Oliveira Terzi Gabriel Cordeiro Camargo Daniella Braz Parente Ana Maria Pittella Gilberto Silva-Junior Gabrielle Gonçalves de Novaes Jaime Araújo Oliveira Neto Julia Machado Barroso Martha Valéria Tavares Pinheiro Adriana Soares Xavier de Brito Renée Sarmento de Oliveira Rosana Souza Rodrigues Renata de Mello Perez Andréa Silvestre de Sousa Renata Junqueira Moll-Bernardes How Cardiac Fibrosis Assessed via T1 Mapping Is Associated with Liver Fibrosis in Patients with Non-Alcoholic Fatty Liver Disease Journal of Clinical Medicine nonalcoholic fatty liver disease cardiovascular disease fibrosis myocardial extracellular volume magnetic resonance |
| title | How Cardiac Fibrosis Assessed via T1 Mapping Is Associated with Liver Fibrosis in Patients with Non-Alcoholic Fatty Liver Disease |
| title_full | How Cardiac Fibrosis Assessed via T1 Mapping Is Associated with Liver Fibrosis in Patients with Non-Alcoholic Fatty Liver Disease |
| title_fullStr | How Cardiac Fibrosis Assessed via T1 Mapping Is Associated with Liver Fibrosis in Patients with Non-Alcoholic Fatty Liver Disease |
| title_full_unstemmed | How Cardiac Fibrosis Assessed via T1 Mapping Is Associated with Liver Fibrosis in Patients with Non-Alcoholic Fatty Liver Disease |
| title_short | How Cardiac Fibrosis Assessed via T1 Mapping Is Associated with Liver Fibrosis in Patients with Non-Alcoholic Fatty Liver Disease |
| title_sort | how cardiac fibrosis assessed via t1 mapping is associated with liver fibrosis in patients with non alcoholic fatty liver disease |
| topic | nonalcoholic fatty liver disease cardiovascular disease fibrosis myocardial extracellular volume magnetic resonance |
| url | https://www.mdpi.com/2077-0383/12/23/7381 |
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