Modeling the spatial propagation of Aβ oligomers in Alzheimer’s Disease
Recent advances in the study of Alzheimer’s Disease and the role of Aβ amyloid formation have caused the focus of biologists to progressively shift towards the smaller protein assemblies, the oligomers. These appear very early on in the disease progression and they seem to be the most infectious spe...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
EDP Sciences
2020-01-01
|
| Series: | ESAIM: Proceedings and Surveys |
| Online Access: | https://www.esaim-proc.org/articles/proc/pdf/2020/01/proc206703.pdf |
| _version_ | 1797970420926775296 |
|---|---|
| author | Andrade-Restrepo Martin Lemarre Paul Pujo-Menjouet Laurent Tine Leon Matar Ciuperca Sorin Ionel |
| author_facet | Andrade-Restrepo Martin Lemarre Paul Pujo-Menjouet Laurent Tine Leon Matar Ciuperca Sorin Ionel |
| author_sort | Andrade-Restrepo Martin |
| collection | DOAJ |
| description | Recent advances in the study of Alzheimer’s Disease and the role of Aβ amyloid formation have caused the focus of biologists to progressively shift towards the smaller protein assemblies, the oligomers. These appear very early on in the disease progression and they seem to be the most infectious species for the neurons. We suggest a model of spatial propagation of Aβ oligomers in the vicinity of a few neurons, without considering the formation of large fibrils or plaques. We also include a simple representation of the oligomers neurotoxic effect. A numerical study reveals that the oligomers spatial dynamics are very sensitive to the balance between their diffusion and their replication, and that the outcome in terms of the progression of AD strongly depends on it. |
| first_indexed | 2024-04-11T03:17:37Z |
| format | Article |
| id | doaj.art-d642f2abf1ef4f90a1ed35d911ff89b9 |
| institution | Directory Open Access Journal |
| issn | 2267-3059 |
| language | English |
| last_indexed | 2024-04-11T03:17:37Z |
| publishDate | 2020-01-01 |
| publisher | EDP Sciences |
| record_format | Article |
| series | ESAIM: Proceedings and Surveys |
| spelling | doaj.art-d642f2abf1ef4f90a1ed35d911ff89b92023-01-02T10:03:44ZengEDP SciencesESAIM: Proceedings and Surveys2267-30592020-01-0167304510.1051/proc/202067003proc206703Modeling the spatial propagation of Aβ oligomers in Alzheimer’s DiseaseAndrade-Restrepo Martin0Lemarre PaulPujo-Menjouet LaurentTine Leon MatarCiuperca Sorin Ionel1Institut Jacques Monod, CNRS UMR 7592, Université Paris Diderot, Paris Cité SorbonneInstitut Camille Jordan, Université de Lyon, Université Claude Bernard Lyon 1, CNRS UMR 5208Recent advances in the study of Alzheimer’s Disease and the role of Aβ amyloid formation have caused the focus of biologists to progressively shift towards the smaller protein assemblies, the oligomers. These appear very early on in the disease progression and they seem to be the most infectious species for the neurons. We suggest a model of spatial propagation of Aβ oligomers in the vicinity of a few neurons, without considering the formation of large fibrils or plaques. We also include a simple representation of the oligomers neurotoxic effect. A numerical study reveals that the oligomers spatial dynamics are very sensitive to the balance between their diffusion and their replication, and that the outcome in terms of the progression of AD strongly depends on it.https://www.esaim-proc.org/articles/proc/pdf/2020/01/proc206703.pdf |
| spellingShingle | Andrade-Restrepo Martin Lemarre Paul Pujo-Menjouet Laurent Tine Leon Matar Ciuperca Sorin Ionel Modeling the spatial propagation of Aβ oligomers in Alzheimer’s Disease ESAIM: Proceedings and Surveys |
| title | Modeling the spatial propagation of Aβ oligomers in Alzheimer’s Disease |
| title_full | Modeling the spatial propagation of Aβ oligomers in Alzheimer’s Disease |
| title_fullStr | Modeling the spatial propagation of Aβ oligomers in Alzheimer’s Disease |
| title_full_unstemmed | Modeling the spatial propagation of Aβ oligomers in Alzheimer’s Disease |
| title_short | Modeling the spatial propagation of Aβ oligomers in Alzheimer’s Disease |
| title_sort | modeling the spatial propagation of aβ oligomers in alzheimer s disease |
| url | https://www.esaim-proc.org/articles/proc/pdf/2020/01/proc206703.pdf |
| work_keys_str_mv | AT andraderestrepomartin modelingthespatialpropagationofaboligomersinalzheimersdisease AT lemarrepaul modelingthespatialpropagationofaboligomersinalzheimersdisease AT pujomenjouetlaurent modelingthespatialpropagationofaboligomersinalzheimersdisease AT tineleonmatar modelingthespatialpropagationofaboligomersinalzheimersdisease AT ciupercasorinionel modelingthespatialpropagationofaboligomersinalzheimersdisease |