Breast Cancer Incidence Reduction in Women Treated with Subcutaneous Testosterone: Testosterone Therapy and Breast Cancer Incidence Study
Objective:Testosterone (T) therapy has been shown to be breast protective in both pre- and post-menopausal patients. Additionally, estradiol (E) does not cause breast cancer (BC) in the majority of the world’s literatures. This study aimed to investigate the incidence of invasive BC (IBC) in pre- an...
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| Format: | Article |
| Language: | English |
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Galenos Publishing House
2021-04-01
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| Series: | European Journal of Breast Health |
| Subjects: | |
| Online Access: |
http://www.eurjbreasthealth.com/archives/archive-detail/article-preview/breast-cancer-ncidence-reduction-in-women-treated-/47126
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| _version_ | 1797910409313779712 |
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| author | Gary Donovitz Mandy Cotten |
| author_facet | Gary Donovitz Mandy Cotten |
| author_sort | Gary Donovitz |
| collection | DOAJ |
| description | Objective:Testosterone (T) therapy has been shown to be breast protective in both pre- and post-menopausal patients. Additionally, estradiol (E) does not cause breast cancer (BC) in the majority of the world’s literatures. This study aimed to investigate the incidence of invasive BC (IBC) in pre- and postmenopausal women treated with T therapy and T in combination with E (T/E).Materials and Methods:Since January 2010, a total of 2,377 pre- and post-menopausal women were treated with T or T/E implants. IBC rates were reported based on newly diagnosed IBC cases in the total study. Total cases divided by the total sample size and years in study was expressed as an incidence per 100,000 person-years (P-Ys). The BC incidence was compared with age-specific Surveillance Epidemiology and End Results (SEER) incidence rates.Results:As of October 2020, 14 cases diagnosed with IBC have been found in 9,746 P-Y of follow up for an incidence of 144 cases per 100,000 P-Y, substantially less than the age-specific SEER incidence rates (223/100,000), placebo arm of Women’s Health Initiative Study (330/100,000), and never users of hormone therapy from the Million Women Study (312/100,000).Conclusion:T and/or T/E pellet implants significantly reduced the incidence of BC in pre- and post-menopausal women. The addition of E did not increase the incidence over using T alone. This is the second multi-year long-term study demonstrating the benefits of T therapy in reducing the incidence of IBC. |
| first_indexed | 2024-04-10T11:24:54Z |
| format | Article |
| id | doaj.art-d64434e76f8e4aa3a939f4f68f4cd9ed |
| institution | Directory Open Access Journal |
| issn | 2587-0831 |
| language | English |
| last_indexed | 2024-04-10T11:24:54Z |
| publishDate | 2021-04-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | European Journal of Breast Health |
| spelling | doaj.art-d64434e76f8e4aa3a939f4f68f4cd9ed2023-02-15T16:18:30ZengGalenos Publishing HouseEuropean Journal of Breast Health2587-08312021-04-0117215015610.4274/ejbh.galenos.2021.621313049054Breast Cancer Incidence Reduction in Women Treated with Subcutaneous Testosterone: Testosterone Therapy and Breast Cancer Incidence StudyGary Donovitz0Mandy Cotten1 Morehouse College of Medicine, Atlanta, Georgia, USA Institute for Hormonal Balance, Arlington, Texas, USA Objective:Testosterone (T) therapy has been shown to be breast protective in both pre- and post-menopausal patients. Additionally, estradiol (E) does not cause breast cancer (BC) in the majority of the world’s literatures. This study aimed to investigate the incidence of invasive BC (IBC) in pre- and postmenopausal women treated with T therapy and T in combination with E (T/E).Materials and Methods:Since January 2010, a total of 2,377 pre- and post-menopausal women were treated with T or T/E implants. IBC rates were reported based on newly diagnosed IBC cases in the total study. Total cases divided by the total sample size and years in study was expressed as an incidence per 100,000 person-years (P-Ys). The BC incidence was compared with age-specific Surveillance Epidemiology and End Results (SEER) incidence rates.Results:As of October 2020, 14 cases diagnosed with IBC have been found in 9,746 P-Y of follow up for an incidence of 144 cases per 100,000 P-Y, substantially less than the age-specific SEER incidence rates (223/100,000), placebo arm of Women’s Health Initiative Study (330/100,000), and never users of hormone therapy from the Million Women Study (312/100,000).Conclusion:T and/or T/E pellet implants significantly reduced the incidence of BC in pre- and post-menopausal women. The addition of E did not increase the incidence over using T alone. This is the second multi-year long-term study demonstrating the benefits of T therapy in reducing the incidence of IBC. http://www.eurjbreasthealth.com/archives/archive-detail/article-preview/breast-cancer-ncidence-reduction-in-women-treated-/47126 pellettestosterone pellet implantationestradiolbreast cancer riskhormone replacement therapy |
| spellingShingle | Gary Donovitz Mandy Cotten Breast Cancer Incidence Reduction in Women Treated with Subcutaneous Testosterone: Testosterone Therapy and Breast Cancer Incidence Study European Journal of Breast Health pellet testosterone pellet implantation estradiol breast cancer risk hormone replacement therapy |
| title | Breast Cancer Incidence Reduction in Women Treated with Subcutaneous Testosterone: Testosterone Therapy and Breast Cancer Incidence Study |
| title_full | Breast Cancer Incidence Reduction in Women Treated with Subcutaneous Testosterone: Testosterone Therapy and Breast Cancer Incidence Study |
| title_fullStr | Breast Cancer Incidence Reduction in Women Treated with Subcutaneous Testosterone: Testosterone Therapy and Breast Cancer Incidence Study |
| title_full_unstemmed | Breast Cancer Incidence Reduction in Women Treated with Subcutaneous Testosterone: Testosterone Therapy and Breast Cancer Incidence Study |
| title_short | Breast Cancer Incidence Reduction in Women Treated with Subcutaneous Testosterone: Testosterone Therapy and Breast Cancer Incidence Study |
| title_sort | breast cancer incidence reduction in women treated with subcutaneous testosterone testosterone therapy and breast cancer incidence study |
| topic | pellet testosterone pellet implantation estradiol breast cancer risk hormone replacement therapy |
| url |
http://www.eurjbreasthealth.com/archives/archive-detail/article-preview/breast-cancer-ncidence-reduction-in-women-treated-/47126
|
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