Low serum calcium is a novel predictor of unfavorable prognosis after traumatic brain injury
Background: Accurate and convenient serological markers for prognosis after traumatic brain injury (TBI) are still lacking. We aimed to explore the predictive value of serum calcium for prognosing outcomes within 6 months after TBI. Methods: In this multicenter retrospective study, 1255 and 719 pati...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-08-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844023056839 |
| _version_ | 1797733024670941184 |
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| author | Tian Li Dongzhou Zhuang Shirong Cai Faxiu Ding Fei Tian Mindong Huang Lianjie Li Weiqiang Chen Kangsheng Li Jiangtao Sheng |
| author_facet | Tian Li Dongzhou Zhuang Shirong Cai Faxiu Ding Fei Tian Mindong Huang Lianjie Li Weiqiang Chen Kangsheng Li Jiangtao Sheng |
| author_sort | Tian Li |
| collection | DOAJ |
| description | Background: Accurate and convenient serological markers for prognosis after traumatic brain injury (TBI) are still lacking. We aimed to explore the predictive value of serum calcium for prognosing outcomes within 6 months after TBI. Methods: In this multicenter retrospective study, 1255 and 719 patients were included in development and validation cohorts, respectively, and their 6-month prognoses were recorded. Serum calcium was measured through routine blood tests within 24 h of hospital admission. Two multivariate predictive models with or without serum calcium for prognosis were developed. Receiver operating characteristics and calibration curves were applied to estimate their performance. Results: The patients with lower serum calcium levels had a higher frequency of unfavorable 6-month prognosis than those without. Lower serum calcium level at admission was associated with an unfavorable 6-month prognosis in a wide spectrum of patients with TBI. Lower serum calcium level and our prognostic model including calcium performed well in predicting the 6-month unfavorable outcome. The calcium nomogram maintained excellent performance in discrimination and calibration in the external validation cohort. Conclusions: Lower serum calcium level upon admission is an independent risk factor for an unfavorable 6-month prognosis after TBI. Integrating serum calcium into a multivariate predictive model improves the performance for predicting 6-month unfavorable outcomes. |
| first_indexed | 2024-03-12T12:23:04Z |
| format | Article |
| id | doaj.art-d6476e4e7f094c43a75f821fa18febd2 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-03-12T12:23:04Z |
| publishDate | 2023-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-d6476e4e7f094c43a75f821fa18febd22023-08-30T05:51:27ZengElsevierHeliyon2405-84402023-08-0198e18475Low serum calcium is a novel predictor of unfavorable prognosis after traumatic brain injuryTian Li0Dongzhou Zhuang1Shirong Cai2Faxiu Ding3Fei Tian4Mindong Huang5Lianjie Li6Weiqiang Chen7Kangsheng Li8Jiangtao Sheng9Shantou University Medical College, Department of Microbiology and Immunology & Guangdong Provincial Key Laboratory of Infectious Diseases and Molecular Immunopathology, Shantou, Guangdong, ChinaFirst Affiliated Hospital of Shantou University Medical College, Department of Neurosurgery, Shantou, Guangdong, China; Fuzong Clinical Medical College of Fujian Medical University, Department of Neurosurgery, Fuzhou, Fujian, ChinaFirst Affiliated Hospital of Shantou University Medical College, Department of Neurosurgery, Shantou, Guangdong, ChinaFirst Affiliated Hospital of Shantou University Medical College, Department of Neurosurgery, Shantou, Guangdong, ChinaSecond Affiliated Hospital of Shantou University Medical College, Department of Neurosurgery, Shantou, Guangdong, ChinaAffiliated Jieyang Hospital of Sun Yat-sen University, Department of Neurosurgery, Jieyang, Guangdong, ChinaFuzong Clinical Medical College of Fujian Medical University, Department of Neurosurgery, Fuzhou, Fujian, ChinaFirst Affiliated Hospital of Shantou University Medical College, Department of Neurosurgery, Shantou, Guangdong, China; Corresponding author. First Affiliated Hospital, Shantou University Medical College, 57 Changping Road, Shantou, Guangdong , ChinaShantou University Medical College, Department of Microbiology and Immunology & Guangdong Provincial Key Laboratory of Infectious Diseases and Molecular Immunopathology, Shantou, Guangdong, China; Corresponding author. Shantou University Medical College, 22 Xinling Road, Shantou, Guangdong, China.Shantou University Medical College, Department of Microbiology and Immunology & Guangdong Provincial Key Laboratory of Infectious Diseases and Molecular Immunopathology, Shantou, Guangdong, China; Corresponding author. Shantou University Medical College, 22 Xinling Road, Shantou, Guangdong, China.Background: Accurate and convenient serological markers for prognosis after traumatic brain injury (TBI) are still lacking. We aimed to explore the predictive value of serum calcium for prognosing outcomes within 6 months after TBI. Methods: In this multicenter retrospective study, 1255 and 719 patients were included in development and validation cohorts, respectively, and their 6-month prognoses were recorded. Serum calcium was measured through routine blood tests within 24 h of hospital admission. Two multivariate predictive models with or without serum calcium for prognosis were developed. Receiver operating characteristics and calibration curves were applied to estimate their performance. Results: The patients with lower serum calcium levels had a higher frequency of unfavorable 6-month prognosis than those without. Lower serum calcium level at admission was associated with an unfavorable 6-month prognosis in a wide spectrum of patients with TBI. Lower serum calcium level and our prognostic model including calcium performed well in predicting the 6-month unfavorable outcome. The calcium nomogram maintained excellent performance in discrimination and calibration in the external validation cohort. Conclusions: Lower serum calcium level upon admission is an independent risk factor for an unfavorable 6-month prognosis after TBI. Integrating serum calcium into a multivariate predictive model improves the performance for predicting 6-month unfavorable outcomes.http://www.sciencedirect.com/science/article/pii/S2405844023056839Traumatic brain injurySerological ion markerUnfavorable prognosisSerum calciumPredictive nomogram |
| spellingShingle | Tian Li Dongzhou Zhuang Shirong Cai Faxiu Ding Fei Tian Mindong Huang Lianjie Li Weiqiang Chen Kangsheng Li Jiangtao Sheng Low serum calcium is a novel predictor of unfavorable prognosis after traumatic brain injury Heliyon Traumatic brain injury Serological ion marker Unfavorable prognosis Serum calcium Predictive nomogram |
| title | Low serum calcium is a novel predictor of unfavorable prognosis after traumatic brain injury |
| title_full | Low serum calcium is a novel predictor of unfavorable prognosis after traumatic brain injury |
| title_fullStr | Low serum calcium is a novel predictor of unfavorable prognosis after traumatic brain injury |
| title_full_unstemmed | Low serum calcium is a novel predictor of unfavorable prognosis after traumatic brain injury |
| title_short | Low serum calcium is a novel predictor of unfavorable prognosis after traumatic brain injury |
| title_sort | low serum calcium is a novel predictor of unfavorable prognosis after traumatic brain injury |
| topic | Traumatic brain injury Serological ion marker Unfavorable prognosis Serum calcium Predictive nomogram |
| url | http://www.sciencedirect.com/science/article/pii/S2405844023056839 |
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