Quantitative SARS-CoV-2 subgenomic RNA as a surrogate marker for viral infectivity: Comparison between culture isolation and direct sgRNA quantification

Quantitative SARS-CoV-2 subgenomic RNA as a surrogate marker for viral infectivity: Comparison between culture isolation and direct sgRNA quantification

Detection of subgenomic (sg) SARS-CoV-2 RNAs are frequently used as a correlate of viral infectiousness, but few data about correlation between sg load and viable virus are available. Here, we defined concordance between culture isolation and E and N sgRNA quantification by ddPCR assays in 51 nasoph...

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Bibliographic Details
Main Authors: Rossana Scutari, Silvia Renica, Valeria Cento, Alice Nava, Josè Camilla Sammartino, Alessandro Ferrari, Arianna Pani, Marco Merli, Diana Fanti, Chiara Vismara, Francesco Scaglione, Massimo Puoti, Alessandra Bandera, Andrea Gori, Antonio Piralla, Fausto Baldanti, Carlo Federico Perno, Claudia Alteri
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10473502/?tool=EBI

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