Association of ICAM-1, VCAM-1, CYCLIN D1 and Cathepsin D with Clinicopathological Parameters in Breast Carcinoma; an Immunohistochemical Study
Objective:Breast carcinoma is the most common malignant tumor detected in women. The hypothesis that increased levels of adhesion molecules and Cathepsin D affect cancerous cells moving away the primary tumor and contributes to migration of the cancerous cell and may cause remote organ metastases is...
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| Format: | Article |
| Language: | English |
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Galenos Publishing House
2017-01-01
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| Series: | European Journal of Breast Health |
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http://www.eurjbreasthealth.com/archives/archive-detail/article-preview/association-of-cam-1-vcam-1-cycln-d1-and-cathepsin/42093
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| author | Özgür Külahcı H. Hasan Esen Elife Asut Salim Güngör |
| author_facet | Özgür Külahcı H. Hasan Esen Elife Asut Salim Güngör |
| author_sort | Özgür Külahcı |
| collection | DOAJ |
| description | Objective:Breast carcinoma is the most common malignant tumor detected in women. The hypothesis that increased levels of adhesion molecules and Cathepsin D affect cancerous cells moving away the primary tumor and contributes to migration of the cancerous cell and may cause remote organ metastases is defended. The aim of the present study was to search the association of intracellular adhesion molecule-1 (ICAM-1), vascular adhesion molecule-1 (VCAM-1), Cyclin D1, cathepsin D immunohistochemically with clinicopathological parameters in the patients diagnosed with invasive ductal breast carcinoma.Materials and Methods:The pathological slides of 153 patients diagnosed with invasive ductal carcinoma were evaluated retrospectively. Three groups were created. Group 1 consisted of patients with positive lymph node metastasis and extranodal tumor invasion; Group 2 consisted of patients with positive axillary lymph node metastasis and negative extranodal tumor invasion and Group 3 consisted of the patients with negative axillary lymph node metastasis. In all groups, 20 paraffin blocks belonging to the primary tumor in the breast were stained by ICAM-1, VCAM-1, Cyclin D1 and Cathepsin D. Findings were examined by comparing with clinicopathological parameters.Results:The highest number of metastatic axillary lymph nodes and the highest rate of cathepsin D staining were statistically found in the cases with positive axillary lymph node metastasis and extranodal tumor invasion. CerbB2 was negative in the cases with negative ICAM-1 whereas estrogen receptor and progesterone receptor were positive in the cases with positive VCAM-1.Conclusion:The present study reveals significant results for the patients diagnosed with invasive ductal carcinoma through breast biopsy especially before mastectomy in terms of increased number of metastatic axillary lymph nodes and extranodal tumor invasion by immunohistochemical Cathepsin D stain without any additional invasive intervention. Results of the present study may contribute to monitoring and treatment of the patients in the future. |
| first_indexed | 2024-04-10T11:23:52Z |
| format | Article |
| id | doaj.art-d6483e0185064886a45b0c0c223feb4a |
| institution | Directory Open Access Journal |
| issn | 2587-0831 |
| language | English |
| last_indexed | 2024-04-10T11:23:52Z |
| publishDate | 2017-01-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | European Journal of Breast Health |
| spelling | doaj.art-d6483e0185064886a45b0c0c223feb4a2023-02-15T16:18:31ZengGalenos Publishing HouseEuropean Journal of Breast Health2587-08312017-01-011315910.5152/tjbh.2016.314213049054Association of ICAM-1, VCAM-1, CYCLIN D1 and Cathepsin D with Clinicopathological Parameters in Breast Carcinoma; an Immunohistochemical StudyÖzgür Külahcı0H. Hasan Esen1Elife Asut2Salim Güngör3 Clinic of Pathology, Adana Numune Training and Research Hospital, Adana, Turkey Department of Pathology, Necmettin Erbakan University Meram School of Medicine, Konya, Turkey Clinic of Pathology, Adana Numune Training and Research Hospital, Adana, Turkey Department of Pathology, Necmettin Erbakan University Meram School of Medicine, Konya, Turkey Objective:Breast carcinoma is the most common malignant tumor detected in women. The hypothesis that increased levels of adhesion molecules and Cathepsin D affect cancerous cells moving away the primary tumor and contributes to migration of the cancerous cell and may cause remote organ metastases is defended. The aim of the present study was to search the association of intracellular adhesion molecule-1 (ICAM-1), vascular adhesion molecule-1 (VCAM-1), Cyclin D1, cathepsin D immunohistochemically with clinicopathological parameters in the patients diagnosed with invasive ductal breast carcinoma.Materials and Methods:The pathological slides of 153 patients diagnosed with invasive ductal carcinoma were evaluated retrospectively. Three groups were created. Group 1 consisted of patients with positive lymph node metastasis and extranodal tumor invasion; Group 2 consisted of patients with positive axillary lymph node metastasis and negative extranodal tumor invasion and Group 3 consisted of the patients with negative axillary lymph node metastasis. In all groups, 20 paraffin blocks belonging to the primary tumor in the breast were stained by ICAM-1, VCAM-1, Cyclin D1 and Cathepsin D. Findings were examined by comparing with clinicopathological parameters.Results:The highest number of metastatic axillary lymph nodes and the highest rate of cathepsin D staining were statistically found in the cases with positive axillary lymph node metastasis and extranodal tumor invasion. CerbB2 was negative in the cases with negative ICAM-1 whereas estrogen receptor and progesterone receptor were positive in the cases with positive VCAM-1.Conclusion:The present study reveals significant results for the patients diagnosed with invasive ductal carcinoma through breast biopsy especially before mastectomy in terms of increased number of metastatic axillary lymph nodes and extranodal tumor invasion by immunohistochemical Cathepsin D stain without any additional invasive intervention. Results of the present study may contribute to monitoring and treatment of the patients in the future. http://www.eurjbreasthealth.com/archives/archive-detail/article-preview/association-of-cam-1-vcam-1-cycln-d1-and-cathepsin/42093 breast carcinomacathepsin dimmunohistochemistrymetastasis |
| spellingShingle | Özgür Külahcı H. Hasan Esen Elife Asut Salim Güngör Association of ICAM-1, VCAM-1, CYCLIN D1 and Cathepsin D with Clinicopathological Parameters in Breast Carcinoma; an Immunohistochemical Study European Journal of Breast Health breast carcinoma cathepsin d immunohistochemistry metastasis |
| title | Association of ICAM-1, VCAM-1, CYCLIN D1 and Cathepsin D with Clinicopathological Parameters in Breast Carcinoma; an Immunohistochemical Study |
| title_full | Association of ICAM-1, VCAM-1, CYCLIN D1 and Cathepsin D with Clinicopathological Parameters in Breast Carcinoma; an Immunohistochemical Study |
| title_fullStr | Association of ICAM-1, VCAM-1, CYCLIN D1 and Cathepsin D with Clinicopathological Parameters in Breast Carcinoma; an Immunohistochemical Study |
| title_full_unstemmed | Association of ICAM-1, VCAM-1, CYCLIN D1 and Cathepsin D with Clinicopathological Parameters in Breast Carcinoma; an Immunohistochemical Study |
| title_short | Association of ICAM-1, VCAM-1, CYCLIN D1 and Cathepsin D with Clinicopathological Parameters in Breast Carcinoma; an Immunohistochemical Study |
| title_sort | association of icam 1 vcam 1 cyclin d1 and cathepsin d with clinicopathological parameters in breast carcinoma an immunohistochemical study |
| topic | breast carcinoma cathepsin d immunohistochemistry metastasis |
| url |
http://www.eurjbreasthealth.com/archives/archive-detail/article-preview/association-of-cam-1-vcam-1-cycln-d1-and-cathepsin/42093
|
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