The Clinical Value of 18F-FDG-PET in Autoimmune Encephalitis Associated With LGI1 Antibody
Purpose: The metabolic patterns of 18F-fluoro-2-deoxy-d-glucose positron emission tomography (18F-FDG-PET) in autoimmune encephalitis associated with leucine-rich glioma-inactivated 1 antibody (LGI1 AE) are still unclear. We performed a cohort study to investigate the clinical metabolic characterist...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-06-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fneur.2020.00418/full |
| _version_ | 1830403414503194624 |
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| author | Xiao Liu Wei Shan Wei Shan Wei Shan Xiaobin Zhao Xiaobin Zhao Jiechuan Ren Jiechuan Ren Guoping Ren Guoping Ren Chao Chen Chao Chen Weixiong Shi Weixiong Shi Ruijuan Lv Ruijuan Lv Zhimei Li Zhimei Li Yaou Liu Yaou Liu Lin Ai Lin Ai Qun Wang Qun Wang Qun Wang |
| author_facet | Xiao Liu Wei Shan Wei Shan Wei Shan Xiaobin Zhao Xiaobin Zhao Jiechuan Ren Jiechuan Ren Guoping Ren Guoping Ren Chao Chen Chao Chen Weixiong Shi Weixiong Shi Ruijuan Lv Ruijuan Lv Zhimei Li Zhimei Li Yaou Liu Yaou Liu Lin Ai Lin Ai Qun Wang Qun Wang Qun Wang |
| author_sort | Xiao Liu |
| collection | DOAJ |
| description | Purpose: The metabolic patterns of 18F-fluoro-2-deoxy-d-glucose positron emission tomography (18F-FDG-PET) in autoimmune encephalitis associated with leucine-rich glioma-inactivated 1 antibody (LGI1 AE) are still unclear. We performed a cohort study to investigate the clinical metabolic characteristics and diagnostic value based on 18F-FDG-PET in patients with LGI1 AE.Materials and Methods: A total of 34 patients including 18 patients (53%) in the acute phase and 16 patients (47%) in the chronic phase who were diagnosed with LGI1 AE were retrospectively analyzed from October 2014 to June 2018 at the Department of Neurology in Beijing Tiantan Hospital, the Capital Medical University. The clinical data were collected by searching through electronic medical records.Results: The initial 18F-FDG-PET scan indicated a significant abnormal metabolic pattern in 31 LGI1 AE patients (91%), whereas only 20 patients (59%) showed an abnormal MRI signal (P < 0.05). The 18F-FDG-PET metabolic pattern was reversible after treatment; most of the patients showed an almost normal uptake of 18F-FDG-PET after discharge. Regarding the spatial distribution, the abnormal metabolic pattern in LGI1 AE subjects exhibiting hypermetabolism was specifically located in the basal ganglia (BG) and medial temporal lobe (MTL). BG hypermetabolism was observed in 28 subjects (82%), and 68% of patients showed MTL hypermetabolism. A total of 17 patients (50%) exhibited faciobrachial dystonic seizures (FBDS), and the remaining subjects showed non-FBDS symptoms (50 and 50%). BG-only hypermetabolism was detected in seven subjects in the FBDS subgroup (7/16) but in only one subject in the non-FBDS subgroup (1/15) (44 vs. 7%, P < 0.05).Conclusion:18F-FDG-PET imaging was more sensitive than MRI in the diagnosis of LGI1 AE. Isolated BG hypermetabolism was more frequently observed in subjects with FBDS, suggesting the potential involvement of the BG. |
| first_indexed | 2024-12-20T17:07:56Z |
| format | Article |
| id | doaj.art-d649e62411cc44f896955f43ced0450c |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-20T17:07:56Z |
| publishDate | 2020-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-d649e62411cc44f896955f43ced0450c2022-12-21T19:32:13ZengFrontiers Media S.A.Frontiers in Neurology1664-22952020-06-011110.3389/fneur.2020.00418500347The Clinical Value of 18F-FDG-PET in Autoimmune Encephalitis Associated With LGI1 AntibodyXiao Liu0Wei Shan1Wei Shan2Wei Shan3Xiaobin Zhao4Xiaobin Zhao5Jiechuan Ren6Jiechuan Ren7Guoping Ren8Guoping Ren9Chao Chen10Chao Chen11Weixiong Shi12Weixiong Shi13Ruijuan Lv14Ruijuan Lv15Zhimei Li16Zhimei Li17Yaou Liu18Yaou Liu19Lin Ai20Lin Ai21Qun Wang22Qun Wang23Qun Wang24Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaBeijing Institute for Brain Disorders, Beijing, ChinaChina National Clinical Research Center for Neurological Diseases, Beijing, ChinaChina National Clinical Research Center for Neurological Diseases, Beijing, ChinaDepartment of Nuclear Medicine, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaChina National Clinical Research Center for Neurological Diseases, Beijing, ChinaDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaChina National Clinical Research Center for Neurological Diseases, Beijing, ChinaDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaChina National Clinical Research Center for Neurological Diseases, Beijing, ChinaDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaChina National Clinical Research Center for Neurological Diseases, Beijing, ChinaDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaChina National Clinical Research Center for Neurological Diseases, Beijing, ChinaDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaChina National Clinical Research Center for Neurological Diseases, Beijing, ChinaChina National Clinical Research Center for Neurological Diseases, Beijing, ChinaDepartment of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaChina National Clinical Research Center for Neurological Diseases, Beijing, ChinaDepartment of Nuclear Medicine, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaBeijing Institute for Brain Disorders, Beijing, ChinaChina National Clinical Research Center for Neurological Diseases, Beijing, ChinaPurpose: The metabolic patterns of 18F-fluoro-2-deoxy-d-glucose positron emission tomography (18F-FDG-PET) in autoimmune encephalitis associated with leucine-rich glioma-inactivated 1 antibody (LGI1 AE) are still unclear. We performed a cohort study to investigate the clinical metabolic characteristics and diagnostic value based on 18F-FDG-PET in patients with LGI1 AE.Materials and Methods: A total of 34 patients including 18 patients (53%) in the acute phase and 16 patients (47%) in the chronic phase who were diagnosed with LGI1 AE were retrospectively analyzed from October 2014 to June 2018 at the Department of Neurology in Beijing Tiantan Hospital, the Capital Medical University. The clinical data were collected by searching through electronic medical records.Results: The initial 18F-FDG-PET scan indicated a significant abnormal metabolic pattern in 31 LGI1 AE patients (91%), whereas only 20 patients (59%) showed an abnormal MRI signal (P < 0.05). The 18F-FDG-PET metabolic pattern was reversible after treatment; most of the patients showed an almost normal uptake of 18F-FDG-PET after discharge. Regarding the spatial distribution, the abnormal metabolic pattern in LGI1 AE subjects exhibiting hypermetabolism was specifically located in the basal ganglia (BG) and medial temporal lobe (MTL). BG hypermetabolism was observed in 28 subjects (82%), and 68% of patients showed MTL hypermetabolism. A total of 17 patients (50%) exhibited faciobrachial dystonic seizures (FBDS), and the remaining subjects showed non-FBDS symptoms (50 and 50%). BG-only hypermetabolism was detected in seven subjects in the FBDS subgroup (7/16) but in only one subject in the non-FBDS subgroup (1/15) (44 vs. 7%, P < 0.05).Conclusion:18F-FDG-PET imaging was more sensitive than MRI in the diagnosis of LGI1 AE. Isolated BG hypermetabolism was more frequently observed in subjects with FBDS, suggesting the potential involvement of the BG.https://www.frontiersin.org/article/10.3389/fneur.2020.00418/fullLGI118F-FDG-PETFBDSbasal gangliamedial temporal lobe |
| spellingShingle | Xiao Liu Wei Shan Wei Shan Wei Shan Xiaobin Zhao Xiaobin Zhao Jiechuan Ren Jiechuan Ren Guoping Ren Guoping Ren Chao Chen Chao Chen Weixiong Shi Weixiong Shi Ruijuan Lv Ruijuan Lv Zhimei Li Zhimei Li Yaou Liu Yaou Liu Lin Ai Lin Ai Qun Wang Qun Wang Qun Wang The Clinical Value of 18F-FDG-PET in Autoimmune Encephalitis Associated With LGI1 Antibody Frontiers in Neurology LGI1 18F-FDG-PET FBDS basal ganglia medial temporal lobe |
| title | The Clinical Value of 18F-FDG-PET in Autoimmune Encephalitis Associated With LGI1 Antibody |
| title_full | The Clinical Value of 18F-FDG-PET in Autoimmune Encephalitis Associated With LGI1 Antibody |
| title_fullStr | The Clinical Value of 18F-FDG-PET in Autoimmune Encephalitis Associated With LGI1 Antibody |
| title_full_unstemmed | The Clinical Value of 18F-FDG-PET in Autoimmune Encephalitis Associated With LGI1 Antibody |
| title_short | The Clinical Value of 18F-FDG-PET in Autoimmune Encephalitis Associated With LGI1 Antibody |
| title_sort | clinical value of 18f fdg pet in autoimmune encephalitis associated with lgi1 antibody |
| topic | LGI1 18F-FDG-PET FBDS basal ganglia medial temporal lobe |
| url | https://www.frontiersin.org/article/10.3389/fneur.2020.00418/full |
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