Dynamic dielectrophoretic cell manipulation is enabled by an innovative electronics platform
We report on a portable dielectrophoresis manipulation platform, for the positioning and immobilization of small dielectric objects, such as cells or microbes, using a circular array of up to six symmetrically arranged and independently controllable micro-electrodes. The system’s micro-controller-in...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-09-01
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| Series: | Biosensors and Bioelectronics: X |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590137023000304 |
| _version_ | 1827857113079087104 |
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| author | Lourdes Albina Nirupa Julius Henrik Scheidt Gowri Krishnan Moritz Becker Omar Nassar Sarai M. Torres-Delgado Dario Mager Vlad Badilita Jan G. Korvink |
| author_facet | Lourdes Albina Nirupa Julius Henrik Scheidt Gowri Krishnan Moritz Becker Omar Nassar Sarai M. Torres-Delgado Dario Mager Vlad Badilita Jan G. Korvink |
| author_sort | Lourdes Albina Nirupa Julius |
| collection | DOAJ |
| description | We report on a portable dielectrophoresis manipulation platform, for the positioning and immobilization of small dielectric objects, such as cells or microbes, using a circular array of up to six symmetrically arranged and independently controllable micro-electrodes. The system’s micro-controller-instructed electronic drivers can be operated in three distinct modes. We demonstrate the system’s function by actuating bacterial cells to specific locations and orientations within a region of interest. Using a deep learning approach, we map voltage phase combinations of the six electrodes to geometrical trap position locations, thereby facilitating smooth trajectory planning. |
| first_indexed | 2024-03-12T12:35:43Z |
| format | Article |
| id | doaj.art-d64c76faca8047fcb5143d326c949a6e |
| institution | Directory Open Access Journal |
| issn | 2590-1370 |
| language | English |
| last_indexed | 2024-03-12T12:35:43Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biosensors and Bioelectronics: X |
| spelling | doaj.art-d64c76faca8047fcb5143d326c949a6e2023-08-29T04:17:47ZengElsevierBiosensors and Bioelectronics: X2590-13702023-09-0114100333Dynamic dielectrophoretic cell manipulation is enabled by an innovative electronics platformLourdes Albina Nirupa Julius0Henrik Scheidt1Gowri Krishnan2Moritz Becker3Omar Nassar4Sarai M. Torres-Delgado5Dario Mager6Vlad Badilita7Jan G. Korvink8Institute of Microstructure Technology, Karlsruhe Institute of Technology, Hermann-von-Helmholtz-Platz 1, Eggenstein-Leopoldshafen, 76344, GermanyInstitute of Microstructure Technology, Karlsruhe Institute of Technology, Hermann-von-Helmholtz-Platz 1, Eggenstein-Leopoldshafen, 76344, GermanyInstitute of Microstructure Technology, Karlsruhe Institute of Technology, Hermann-von-Helmholtz-Platz 1, Eggenstein-Leopoldshafen, 76344, GermanyInstitute of Microstructure Technology, Karlsruhe Institute of Technology, Hermann-von-Helmholtz-Platz 1, Eggenstein-Leopoldshafen, 76344, GermanyInstitute of Microstructure Technology, Karlsruhe Institute of Technology, Hermann-von-Helmholtz-Platz 1, Eggenstein-Leopoldshafen, 76344, GermanyInstitute of Microstructure Technology, Karlsruhe Institute of Technology, Hermann-von-Helmholtz-Platz 1, Eggenstein-Leopoldshafen, 76344, GermanyInstitute of Microstructure Technology, Karlsruhe Institute of Technology, Hermann-von-Helmholtz-Platz 1, Eggenstein-Leopoldshafen, 76344, GermanyInstitute of Microstructure Technology, Karlsruhe Institute of Technology, Hermann-von-Helmholtz-Platz 1, Eggenstein-Leopoldshafen, 76344, GermanyCorresponding author.; Institute of Microstructure Technology, Karlsruhe Institute of Technology, Hermann-von-Helmholtz-Platz 1, Eggenstein-Leopoldshafen, 76344, GermanyWe report on a portable dielectrophoresis manipulation platform, for the positioning and immobilization of small dielectric objects, such as cells or microbes, using a circular array of up to six symmetrically arranged and independently controllable micro-electrodes. The system’s micro-controller-instructed electronic drivers can be operated in three distinct modes. We demonstrate the system’s function by actuating bacterial cells to specific locations and orientations within a region of interest. Using a deep learning approach, we map voltage phase combinations of the six electrodes to geometrical trap position locations, thereby facilitating smooth trajectory planning.http://www.sciencedirect.com/science/article/pii/S2590137023000304DielectrophoresisCell/bacterium manipulationArbitrary path controlDeep learning |
| spellingShingle | Lourdes Albina Nirupa Julius Henrik Scheidt Gowri Krishnan Moritz Becker Omar Nassar Sarai M. Torres-Delgado Dario Mager Vlad Badilita Jan G. Korvink Dynamic dielectrophoretic cell manipulation is enabled by an innovative electronics platform Biosensors and Bioelectronics: X Dielectrophoresis Cell/bacterium manipulation Arbitrary path control Deep learning |
| title | Dynamic dielectrophoretic cell manipulation is enabled by an innovative electronics platform |
| title_full | Dynamic dielectrophoretic cell manipulation is enabled by an innovative electronics platform |
| title_fullStr | Dynamic dielectrophoretic cell manipulation is enabled by an innovative electronics platform |
| title_full_unstemmed | Dynamic dielectrophoretic cell manipulation is enabled by an innovative electronics platform |
| title_short | Dynamic dielectrophoretic cell manipulation is enabled by an innovative electronics platform |
| title_sort | dynamic dielectrophoretic cell manipulation is enabled by an innovative electronics platform |
| topic | Dielectrophoresis Cell/bacterium manipulation Arbitrary path control Deep learning |
| url | http://www.sciencedirect.com/science/article/pii/S2590137023000304 |
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