Diagnostic significance of plasma osteopontin in hepatitis C virus-related hepatocellular carcinoma
Background and aim: Outcome of hepatocellular carcinoma (HCC) depends mainly on its early diagnosis. The performance of traditional biomarkers is not satisfactory. Osteopontin (OPN) is of potential importance. This study aim to assess the diagnostic value of plasma OPN compared with alpha-fetoprotei...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2011-07-01
|
| Series: | Annals of Hepatology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1665268119315418 |
| _version_ | 1818608193889107968 |
|---|---|
| author | Mona A. Abu El Makarem, Prof. Ashraf Abdel-Aleem Ahmed Ali Rafet Saber Mohammed Shatat Doaa Abdel Rahem Douaa Sayed |
| author_facet | Mona A. Abu El Makarem, Prof. Ashraf Abdel-Aleem Ahmed Ali Rafet Saber Mohammed Shatat Doaa Abdel Rahem Douaa Sayed |
| author_sort | Mona A. Abu El Makarem, Prof. |
| collection | DOAJ |
| description | Background and aim: Outcome of hepatocellular carcinoma (HCC) depends mainly on its early diagnosis. The performance of traditional biomarkers is not satisfactory. Osteopontin (OPN) is of potential importance. This study aim to assess the diagnostic value of plasma OPN compared with alpha-fetoprotein (AFP) for the diagnosis of HCV- related HCC.Methods: We recruited 113 HCC patients compared with 120 matched cirrhotic patients and 120 Controls. The plasma level of OPN and serum AFP for all participants were assessed.Results: The median plasma OPN level was significantly higher in the HCC group than in the cirrhotic patient group or in the normal control group (p-value < 0.001), while OPN levels were not differed significantly in correlation with the degree of liver function deterioration in terms of advanced Child-Pugh class (p-value < 0.9). The diagnostic efficacy of OPN were superior to AFP in terms of AUC, sensitivity, specificity, PPV and NPV either in diagnosis of early or late stages of HCC (0.88 vs. 0.56; P = 0.0001, 0.991 vs. 0.899; p = 0.01; respectively).Conclusion: Plasma OPN level is a potential diagnostic marker for HCC, especially among high-risk group of patients. These values extend beyond the traditional tumor biomarkers as AFP, as it possesses good prognostic value. |
| first_indexed | 2024-12-16T14:38:46Z |
| format | Article |
| id | doaj.art-d64c7c5697e643bc91343ffe2fd88538 |
| institution | Directory Open Access Journal |
| issn | 1665-2681 |
| language | English |
| last_indexed | 2024-12-16T14:38:46Z |
| publishDate | 2011-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Annals of Hepatology |
| spelling | doaj.art-d64c7c5697e643bc91343ffe2fd885382022-12-21T22:28:01ZengElsevierAnnals of Hepatology1665-26812011-07-01103296305Diagnostic significance of plasma osteopontin in hepatitis C virus-related hepatocellular carcinomaMona A. Abu El Makarem, Prof.0Ashraf Abdel-Aleem1Ahmed Ali2Rafet Saber3Mohammed Shatat4Doaa Abdel Rahem5Douaa Sayed6Department of Internal Medicine, Medical School, Minia University, Egypt.; Correspondence and reprint request:Department of Internal Medicine, Medical School, Minia University, Egypt.Department of Internal Medicine, Medical School, Minia University, Egypt.Department of Oncology, Medical School, Minia University, Egypt.Department of Internal Medicine, Medical School, Minia University, Egypt.Department of Internal Medicine, Medical School, Minia University, Egypt.Flow Cytometry Lab, Clinical Pathology Department, South Egypt Cancer Institute, Assiut University, Egypt.Background and aim: Outcome of hepatocellular carcinoma (HCC) depends mainly on its early diagnosis. The performance of traditional biomarkers is not satisfactory. Osteopontin (OPN) is of potential importance. This study aim to assess the diagnostic value of plasma OPN compared with alpha-fetoprotein (AFP) for the diagnosis of HCV- related HCC.Methods: We recruited 113 HCC patients compared with 120 matched cirrhotic patients and 120 Controls. The plasma level of OPN and serum AFP for all participants were assessed.Results: The median plasma OPN level was significantly higher in the HCC group than in the cirrhotic patient group or in the normal control group (p-value < 0.001), while OPN levels were not differed significantly in correlation with the degree of liver function deterioration in terms of advanced Child-Pugh class (p-value < 0.9). The diagnostic efficacy of OPN were superior to AFP in terms of AUC, sensitivity, specificity, PPV and NPV either in diagnosis of early or late stages of HCC (0.88 vs. 0.56; P = 0.0001, 0.991 vs. 0.899; p = 0.01; respectively).Conclusion: Plasma OPN level is a potential diagnostic marker for HCC, especially among high-risk group of patients. These values extend beyond the traditional tumor biomarkers as AFP, as it possesses good prognostic value.http://www.sciencedirect.com/science/article/pii/S1665268119315418OsteopontinHepatitis C virus infectionHepatocellular carcinomaDiagnosisPrognosis |
| spellingShingle | Mona A. Abu El Makarem, Prof. Ashraf Abdel-Aleem Ahmed Ali Rafet Saber Mohammed Shatat Doaa Abdel Rahem Douaa Sayed Diagnostic significance of plasma osteopontin in hepatitis C virus-related hepatocellular carcinoma Annals of Hepatology Osteopontin Hepatitis C virus infection Hepatocellular carcinoma Diagnosis Prognosis |
| title | Diagnostic significance of plasma osteopontin in hepatitis C virus-related hepatocellular carcinoma |
| title_full | Diagnostic significance of plasma osteopontin in hepatitis C virus-related hepatocellular carcinoma |
| title_fullStr | Diagnostic significance of plasma osteopontin in hepatitis C virus-related hepatocellular carcinoma |
| title_full_unstemmed | Diagnostic significance of plasma osteopontin in hepatitis C virus-related hepatocellular carcinoma |
| title_short | Diagnostic significance of plasma osteopontin in hepatitis C virus-related hepatocellular carcinoma |
| title_sort | diagnostic significance of plasma osteopontin in hepatitis c virus related hepatocellular carcinoma |
| topic | Osteopontin Hepatitis C virus infection Hepatocellular carcinoma Diagnosis Prognosis |
| url | http://www.sciencedirect.com/science/article/pii/S1665268119315418 |
| work_keys_str_mv | AT monaaabuelmakaremprof diagnosticsignificanceofplasmaosteopontininhepatitiscvirusrelatedhepatocellularcarcinoma AT ashrafabdelaleem diagnosticsignificanceofplasmaosteopontininhepatitiscvirusrelatedhepatocellularcarcinoma AT ahmedali diagnosticsignificanceofplasmaosteopontininhepatitiscvirusrelatedhepatocellularcarcinoma AT rafetsaber diagnosticsignificanceofplasmaosteopontininhepatitiscvirusrelatedhepatocellularcarcinoma AT mohammedshatat diagnosticsignificanceofplasmaosteopontininhepatitiscvirusrelatedhepatocellularcarcinoma AT doaaabdelrahem diagnosticsignificanceofplasmaosteopontininhepatitiscvirusrelatedhepatocellularcarcinoma AT douaasayed diagnosticsignificanceofplasmaosteopontininhepatitiscvirusrelatedhepatocellularcarcinoma |