The bidirectional relationship between AMPK pathway activation and myokine secretion in skeletal muscle: How it affects energy metabolism
Myokines are peptides and proteins secreted by skeletal muscle cells, into the interstitium, or in the blood. Their regulation may be dependent or independent of muscle contraction to induce a variety of metabolic effects. Numerous myokines have been implicated in influencing energy metabolism via A...
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Frontiers Media S.A.
2022-11-01
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Series: | Frontiers in Physiology |
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Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2022.1040809/full |
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author | Mahdi Ahsan Léa Garneau Léa Garneau Céline Aguer Céline Aguer Céline Aguer Céline Aguer Céline Aguer |
author_facet | Mahdi Ahsan Léa Garneau Léa Garneau Céline Aguer Céline Aguer Céline Aguer Céline Aguer Céline Aguer |
author_sort | Mahdi Ahsan |
collection | DOAJ |
description | Myokines are peptides and proteins secreted by skeletal muscle cells, into the interstitium, or in the blood. Their regulation may be dependent or independent of muscle contraction to induce a variety of metabolic effects. Numerous myokines have been implicated in influencing energy metabolism via AMP-activated protein kinase (AMPK) signalling. As AMPK is centrally involved in glucose and lipid metabolism, it is important to understand how myokines influence its signalling, and vice versa. Such insight will better elucidate the mechanism of metabolic regulation during exercise and at rest. This review encompasses the latest research conducted on the relationship between AMPK signalling and myokines within skeletal muscles via autocrine or paracrine signalling. |
first_indexed | 2024-04-11T14:34:40Z |
format | Article |
id | doaj.art-d64ca10336f145b8ba24852a90c9ef16 |
institution | Directory Open Access Journal |
issn | 1664-042X |
language | English |
last_indexed | 2024-04-11T14:34:40Z |
publishDate | 2022-11-01 |
publisher | Frontiers Media S.A. |
record_format | Article |
series | Frontiers in Physiology |
spelling | doaj.art-d64ca10336f145b8ba24852a90c9ef162022-12-22T04:18:25ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2022-11-011310.3389/fphys.2022.10408091040809The bidirectional relationship between AMPK pathway activation and myokine secretion in skeletal muscle: How it affects energy metabolismMahdi Ahsan0Léa Garneau1Léa Garneau2Céline Aguer3Céline Aguer4Céline Aguer5Céline Aguer6Céline Aguer7Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, CanadaDepartment of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, CanadaInstitut du Savoir Montfort –Recherche, Ottawa, ON, CanadaDepartment of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, CanadaInstitut du Savoir Montfort –Recherche, Ottawa, ON, CanadaDepartment of Physiology, Faculty of Medicine and Health Sciences, McGill University—Campus Outaouais, Gatineau, QC, CanadaSchool of Human Kinetics, Faculty of Health Sciences, University of Ottawa, Ottawa, ON, CanadaInterdisciplinary School of Health Sciences, Faculty of Health Sciences, University of Ottawa, Ottawa, ON, CanadaMyokines are peptides and proteins secreted by skeletal muscle cells, into the interstitium, or in the blood. Their regulation may be dependent or independent of muscle contraction to induce a variety of metabolic effects. Numerous myokines have been implicated in influencing energy metabolism via AMP-activated protein kinase (AMPK) signalling. As AMPK is centrally involved in glucose and lipid metabolism, it is important to understand how myokines influence its signalling, and vice versa. Such insight will better elucidate the mechanism of metabolic regulation during exercise and at rest. This review encompasses the latest research conducted on the relationship between AMPK signalling and myokines within skeletal muscles via autocrine or paracrine signalling.https://www.frontiersin.org/articles/10.3389/fphys.2022.1040809/fullmyokinesAMPKskeletal musclecell signallingglucose metabolismlipid metabolism |
spellingShingle | Mahdi Ahsan Léa Garneau Léa Garneau Céline Aguer Céline Aguer Céline Aguer Céline Aguer Céline Aguer The bidirectional relationship between AMPK pathway activation and myokine secretion in skeletal muscle: How it affects energy metabolism Frontiers in Physiology myokines AMPK skeletal muscle cell signalling glucose metabolism lipid metabolism |
title | The bidirectional relationship between AMPK pathway activation and myokine secretion in skeletal muscle: How it affects energy metabolism |
title_full | The bidirectional relationship between AMPK pathway activation and myokine secretion in skeletal muscle: How it affects energy metabolism |
title_fullStr | The bidirectional relationship between AMPK pathway activation and myokine secretion in skeletal muscle: How it affects energy metabolism |
title_full_unstemmed | The bidirectional relationship between AMPK pathway activation and myokine secretion in skeletal muscle: How it affects energy metabolism |
title_short | The bidirectional relationship between AMPK pathway activation and myokine secretion in skeletal muscle: How it affects energy metabolism |
title_sort | bidirectional relationship between ampk pathway activation and myokine secretion in skeletal muscle how it affects energy metabolism |
topic | myokines AMPK skeletal muscle cell signalling glucose metabolism lipid metabolism |
url | https://www.frontiersin.org/articles/10.3389/fphys.2022.1040809/full |
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