Correlation between ADC Histogram-Derived Metrics and the Time to Metastases in Resectable Pancreatic Adenocarcinoma
Background: A non-invasive method to improve the prognostic stratification would be clinically beneficial in patients with resectable pancreatic adenocarcinoma (PDAC). The aim of this study was to correlate conventional magnetic resonance (MR) features and the metrics derived from the histogram anal...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/14/24/6050 |
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| author | Riccardo De Robertis Luisa Tomaiuolo Francesca Pasquazzo Luca Geraci Giuseppe Malleo Roberto Salvia Mirko D’Onofrio |
| author_facet | Riccardo De Robertis Luisa Tomaiuolo Francesca Pasquazzo Luca Geraci Giuseppe Malleo Roberto Salvia Mirko D’Onofrio |
| author_sort | Riccardo De Robertis |
| collection | DOAJ |
| description | Background: A non-invasive method to improve the prognostic stratification would be clinically beneficial in patients with resectable pancreatic adenocarcinoma (PDAC). The aim of this study was to correlate conventional magnetic resonance (MR) features and the metrics derived from the histogram analysis of apparent diffusion coefficient (ADC) maps, with the risk and the time to metastases (TTM) after surgery in patients with PDAC. Methods: pre-operative MR examinations of 120 patients were retrospectively analyzed. Patients were grouped according to the presence (M+) or absence (M−) of metastases during follow-up. Conventional MR features and histogram-derived metrics were compared between M+ and M− patients using the Fisher’s or Mann–Whitney tests; receiver operating characteristic (ROC) curves were constructed for the features that showed a significant difference between groups. A Cox regression analysis was performed to identify the features with a significant effect on the TTM, and Kaplan–Meier curves were constructed for significant features. Results: 68.3% patients developed metastases over a mean follow-up time of 29 months (range, 3–54 months). ADC skewness and kurtosis were significantly higher in M+ than in M− patients (<i>p</i> < 0.001). Skewness had a significant effect on the risk of metastases (hazard ratio—HR = 5.22, <i>p</i> < 0.001). Patients with an ADC skewness ≥0.23 had a significantly shorter TTM than those with a skewness <0.22 (11.7 vs. 30.8 months, <i>p</i> < 0.001). Conclusions: pre-operative histogram analysis of ADC maps provides parameters correlated to the metastatic potential of PDAC. Higher ADC skewness seems to be associated with a significantly shorter TTM in patients with resectable PDAC. |
| first_indexed | 2024-03-09T17:14:45Z |
| format | Article |
| id | doaj.art-d64ce14a55b14b6abbd23a4da1d3fe84 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T17:14:45Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-d64ce14a55b14b6abbd23a4da1d3fe842023-11-24T13:45:20ZengMDPI AGCancers2072-66942022-12-011424605010.3390/cancers14246050Correlation between ADC Histogram-Derived Metrics and the Time to Metastases in Resectable Pancreatic AdenocarcinomaRiccardo De Robertis0Luisa Tomaiuolo1Francesca Pasquazzo2Luca Geraci3Giuseppe Malleo4Roberto Salvia5Mirko D’Onofrio6Department of Radiology, Ospedale G.B. Rossi, University of Verona, 37134 Verona, ItalyDepartment of Radiology, Ospedale G.B. Rossi, University of Verona, 37134 Verona, ItalyDepartment of Radiology, Ospedale G.B. Rossi, University of Verona, 37134 Verona, ItalyDepartment of Radiology, Ospedale G.B. Rossi, University of Verona, 37134 Verona, ItalyDepartment of Pancreatic Surgery, Ospedale G.B. Rossi, University of Verona, 37134 Verona, ItalyDepartment of Pancreatic Surgery, Ospedale G.B. Rossi, University of Verona, 37134 Verona, ItalyDepartment of Radiology, Ospedale G.B. Rossi, University of Verona, 37134 Verona, ItalyBackground: A non-invasive method to improve the prognostic stratification would be clinically beneficial in patients with resectable pancreatic adenocarcinoma (PDAC). The aim of this study was to correlate conventional magnetic resonance (MR) features and the metrics derived from the histogram analysis of apparent diffusion coefficient (ADC) maps, with the risk and the time to metastases (TTM) after surgery in patients with PDAC. Methods: pre-operative MR examinations of 120 patients were retrospectively analyzed. Patients were grouped according to the presence (M+) or absence (M−) of metastases during follow-up. Conventional MR features and histogram-derived metrics were compared between M+ and M− patients using the Fisher’s or Mann–Whitney tests; receiver operating characteristic (ROC) curves were constructed for the features that showed a significant difference between groups. A Cox regression analysis was performed to identify the features with a significant effect on the TTM, and Kaplan–Meier curves were constructed for significant features. Results: 68.3% patients developed metastases over a mean follow-up time of 29 months (range, 3–54 months). ADC skewness and kurtosis were significantly higher in M+ than in M− patients (<i>p</i> < 0.001). Skewness had a significant effect on the risk of metastases (hazard ratio—HR = 5.22, <i>p</i> < 0.001). Patients with an ADC skewness ≥0.23 had a significantly shorter TTM than those with a skewness <0.22 (11.7 vs. 30.8 months, <i>p</i> < 0.001). Conclusions: pre-operative histogram analysis of ADC maps provides parameters correlated to the metastatic potential of PDAC. Higher ADC skewness seems to be associated with a significantly shorter TTM in patients with resectable PDAC.https://www.mdpi.com/2072-6694/14/24/6050pancreasradiomicshistogram analysismagnetic resonance imagingmetastasispancreatic carcinoma |
| spellingShingle | Riccardo De Robertis Luisa Tomaiuolo Francesca Pasquazzo Luca Geraci Giuseppe Malleo Roberto Salvia Mirko D’Onofrio Correlation between ADC Histogram-Derived Metrics and the Time to Metastases in Resectable Pancreatic Adenocarcinoma Cancers pancreas radiomics histogram analysis magnetic resonance imaging metastasis pancreatic carcinoma |
| title | Correlation between ADC Histogram-Derived Metrics and the Time to Metastases in Resectable Pancreatic Adenocarcinoma |
| title_full | Correlation between ADC Histogram-Derived Metrics and the Time to Metastases in Resectable Pancreatic Adenocarcinoma |
| title_fullStr | Correlation between ADC Histogram-Derived Metrics and the Time to Metastases in Resectable Pancreatic Adenocarcinoma |
| title_full_unstemmed | Correlation between ADC Histogram-Derived Metrics and the Time to Metastases in Resectable Pancreatic Adenocarcinoma |
| title_short | Correlation between ADC Histogram-Derived Metrics and the Time to Metastases in Resectable Pancreatic Adenocarcinoma |
| title_sort | correlation between adc histogram derived metrics and the time to metastases in resectable pancreatic adenocarcinoma |
| topic | pancreas radiomics histogram analysis magnetic resonance imaging metastasis pancreatic carcinoma |
| url | https://www.mdpi.com/2072-6694/14/24/6050 |
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