The human sirtuin family: Evolutionary divergences and functions
<p>Abstract</p> <p>The sirtuin family of proteins is categorised as class III histone deacetylases that play complex and important roles in ageing-related pathological conditions such as cancer and the deregulation of metabolism. There are seven members in humans, divided into four...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2011-07-01
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| Series: | Human Genomics |
| Subjects: | |
| Online Access: | http://www.humgenomics.com/content/5/5/485 |
| _version_ | 1828153502621237248 |
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| author | Vassilopoulos Athanassios Fritz Kristofer S Petersen Dennis R Gius David |
| author_facet | Vassilopoulos Athanassios Fritz Kristofer S Petersen Dennis R Gius David |
| author_sort | Vassilopoulos Athanassios |
| collection | DOAJ |
| description | <p>Abstract</p> <p>The sirtuin family of proteins is categorised as class III histone deacetylases that play complex and important roles in ageing-related pathological conditions such as cancer and the deregulation of metabolism. There are seven members in humans, divided into four classes, and evolutionarily conserved orthologues can be found in most forms of life, including both eukaryotes and prokaryotes. The highly conserved catalytic core domain composed of a large oxidised nicotinamide adenine dinucleotide (NAD<sup>+</sup>)-binding Rossmann fold subunit suggests that these proteins belong to a family of nutrient-sensing regulators. Along with their function in regulating cellular metabolism in response to stressful conditions, they are implicated in modifying a wide variety of substrates; this increases the complexity of unravelling the interplay of sirtuins and their partners. Over the past few years, all of these new findings have attracted the interest of researchers exploring potential therapeutic implications related to the function of sirtuins. It remains to be elucidated whether, indeed, sirtuins can serve as molecular targets for the treatment of human illnesses.</p> |
| first_indexed | 2024-04-11T22:26:01Z |
| format | Article |
| id | doaj.art-d64d37e68eb947b8b3808c611e9095ca |
| institution | Directory Open Access Journal |
| issn | 1479-7364 |
| language | English |
| last_indexed | 2024-04-11T22:26:01Z |
| publishDate | 2011-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Human Genomics |
| spelling | doaj.art-d64d37e68eb947b8b3808c611e9095ca2022-12-22T03:59:43ZengBMCHuman Genomics1479-73642011-07-015548549610.1186/1479-7364-5-5-485The human sirtuin family: Evolutionary divergences and functionsVassilopoulos AthanassiosFritz Kristofer SPetersen Dennis RGius David<p>Abstract</p> <p>The sirtuin family of proteins is categorised as class III histone deacetylases that play complex and important roles in ageing-related pathological conditions such as cancer and the deregulation of metabolism. There are seven members in humans, divided into four classes, and evolutionarily conserved orthologues can be found in most forms of life, including both eukaryotes and prokaryotes. The highly conserved catalytic core domain composed of a large oxidised nicotinamide adenine dinucleotide (NAD<sup>+</sup>)-binding Rossmann fold subunit suggests that these proteins belong to a family of nutrient-sensing regulators. Along with their function in regulating cellular metabolism in response to stressful conditions, they are implicated in modifying a wide variety of substrates; this increases the complexity of unravelling the interplay of sirtuins and their partners. Over the past few years, all of these new findings have attracted the interest of researchers exploring potential therapeutic implications related to the function of sirtuins. It remains to be elucidated whether, indeed, sirtuins can serve as molecular targets for the treatment of human illnesses.</p>http://www.humgenomics.com/content/5/5/485Evolutionhistone deacetylaseshuman diseasesmetabolismsirtuins |
| spellingShingle | Vassilopoulos Athanassios Fritz Kristofer S Petersen Dennis R Gius David The human sirtuin family: Evolutionary divergences and functions Human Genomics Evolution histone deacetylases human diseases metabolism sirtuins |
| title | The human sirtuin family: Evolutionary divergences and functions |
| title_full | The human sirtuin family: Evolutionary divergences and functions |
| title_fullStr | The human sirtuin family: Evolutionary divergences and functions |
| title_full_unstemmed | The human sirtuin family: Evolutionary divergences and functions |
| title_short | The human sirtuin family: Evolutionary divergences and functions |
| title_sort | human sirtuin family evolutionary divergences and functions |
| topic | Evolution histone deacetylases human diseases metabolism sirtuins |
| url | http://www.humgenomics.com/content/5/5/485 |
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