RAMIPRIL EFFICACY IN PATIENTS WITH ARTERIAL HYPERTENSION AND ISCHEMIC HEART DISEASE
Aim. To study ramipril effect on parameters of ambulatory blood pressure (BP) monitoring, cardio-vascular remodeling parameters in patients with arterial hypertension (HT) and ischemic heart disease (IHD).Material and methods. 40 patients with HT (stage 1-2) combined with IHD (functional class 1-2)...
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| Format: | Article |
| Language: | English |
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Столичная издательская компания
2016-01-01
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| Series: | Рациональная фармакотерапия в кардиологии |
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| Online Access: | https://www.rpcardio.online/jour/article/view/1091 |
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| author | A. I. Chesnikova I. N. Koshenskaja V. P. Terentyev N. N. Mozhaeva I. V. Bedareva L. A. Lavrik T. V. Zhertovsky |
| author_facet | A. I. Chesnikova I. N. Koshenskaja V. P. Terentyev N. N. Mozhaeva I. V. Bedareva L. A. Lavrik T. V. Zhertovsky |
| author_sort | A. I. Chesnikova |
| collection | DOAJ |
| description | Aim. To study ramipril effect on parameters of ambulatory blood pressure (BP) monitoring, cardio-vascular remodeling parameters in patients with arterial hypertension (HT) and ischemic heart disease (IHD).Material and methods. 40 patients with HT (stage 1-2) combined with IHD (functional class 1-2) were included in the study. All patients were randomized in 2 groups. Patients of the 1st group received basic therapy with aspirin, statin and ß-blocker. Patients of the 2nd group received the same therapy as well as ACE inhibitor ramipril (Hartil, EGIS). Changes in clinical status, daily BP profile, cardio-vascular remodeling parameters were evaluated.Results. After 12 week treatment clinical improvement was revealed in the both groups of the patients. Ramipril contributed additional pulse BP and BP loading reduction, regression of left ventricular hypertrophy, improvement of systolic and diastolic left ventricle function, increase in brachial artery diameter.Conclusion. Ramipril inclusion in the basic therapy of patients with HT and IHD increases in efficacy of antihypertensive treatment and improves structural and functional conditions of heart and vessels. |
| first_indexed | 2024-03-08T14:03:28Z |
| format | Article |
| id | doaj.art-d64e578f8e214a948bdf83ad6e69a811 |
| institution | Directory Open Access Journal |
| issn | 1819-6446 2225-3653 |
| language | English |
| last_indexed | 2024-04-24T15:57:23Z |
| publishDate | 2016-01-01 |
| publisher | Столичная издательская компания |
| record_format | Article |
| series | Рациональная фармакотерапия в кардиологии |
| spelling | doaj.art-d64e578f8e214a948bdf83ad6e69a8112024-04-01T07:43:32ZengСтоличная издательская компанияРациональная фармакотерапия в кардиологии1819-64462225-36532016-01-0142414610.20996/1819-6446-2008-4-2-41-461090RAMIPRIL EFFICACY IN PATIENTS WITH ARTERIAL HYPERTENSION AND ISCHEMIC HEART DISEASEA. I. Chesnikova0I. N. Koshenskaja1V. P. Terentyev2N. N. Mozhaeva3I. V. Bedareva4L. A. Lavrik5T. V. Zhertovsky6Rostov State medical universityRostov State medical universityRostov State medical universityRostov State medical universityRostov State medical universityRostov State medical universityRostov State medical universityAim. To study ramipril effect on parameters of ambulatory blood pressure (BP) monitoring, cardio-vascular remodeling parameters in patients with arterial hypertension (HT) and ischemic heart disease (IHD).Material and methods. 40 patients with HT (stage 1-2) combined with IHD (functional class 1-2) were included in the study. All patients were randomized in 2 groups. Patients of the 1st group received basic therapy with aspirin, statin and ß-blocker. Patients of the 2nd group received the same therapy as well as ACE inhibitor ramipril (Hartil, EGIS). Changes in clinical status, daily BP profile, cardio-vascular remodeling parameters were evaluated.Results. After 12 week treatment clinical improvement was revealed in the both groups of the patients. Ramipril contributed additional pulse BP and BP loading reduction, regression of left ventricular hypertrophy, improvement of systolic and diastolic left ventricle function, increase in brachial artery diameter.Conclusion. Ramipril inclusion in the basic therapy of patients with HT and IHD increases in efficacy of antihypertensive treatment and improves structural and functional conditions of heart and vessels.https://www.rpcardio.online/jour/article/view/1091arterial hypertensionischemic heart diseasehemodynamicscardio-vascular remodelingramipril |
| spellingShingle | A. I. Chesnikova I. N. Koshenskaja V. P. Terentyev N. N. Mozhaeva I. V. Bedareva L. A. Lavrik T. V. Zhertovsky RAMIPRIL EFFICACY IN PATIENTS WITH ARTERIAL HYPERTENSION AND ISCHEMIC HEART DISEASE Рациональная фармакотерапия в кардиологии arterial hypertension ischemic heart disease hemodynamics cardio-vascular remodeling ramipril |
| title | RAMIPRIL EFFICACY IN PATIENTS WITH ARTERIAL HYPERTENSION AND ISCHEMIC HEART DISEASE |
| title_full | RAMIPRIL EFFICACY IN PATIENTS WITH ARTERIAL HYPERTENSION AND ISCHEMIC HEART DISEASE |
| title_fullStr | RAMIPRIL EFFICACY IN PATIENTS WITH ARTERIAL HYPERTENSION AND ISCHEMIC HEART DISEASE |
| title_full_unstemmed | RAMIPRIL EFFICACY IN PATIENTS WITH ARTERIAL HYPERTENSION AND ISCHEMIC HEART DISEASE |
| title_short | RAMIPRIL EFFICACY IN PATIENTS WITH ARTERIAL HYPERTENSION AND ISCHEMIC HEART DISEASE |
| title_sort | ramipril efficacy in patients with arterial hypertension and ischemic heart disease |
| topic | arterial hypertension ischemic heart disease hemodynamics cardio-vascular remodeling ramipril |
| url | https://www.rpcardio.online/jour/article/view/1091 |
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