H2O2‐responsive multifunctional nanocomposite for the inhibition of amyloid‐β and Tau aggregation in Alzheimer's disease
Abstract Amyloid‐β (Aβ) and Tau proteins are the main components of Aβ plaques and neurofibrillary tangles in Alzheimer's disease (AD), and their abnormal aggregation is closely related to the pathogenesis of AD. The production of reactive oxygen species (ROS) and the aggregation of Aβ and Tau...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-03-01
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| Series: | BMEMat |
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| Online Access: | https://doi.org/10.1002/bmm2.12011 |
| _version_ | 1827904859529019392 |
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| author | Luying Qiao Yang Shen Shiyu Zhang Man Wang Guanglei Lv Qingqing Dou Chunxia Li |
| author_facet | Luying Qiao Yang Shen Shiyu Zhang Man Wang Guanglei Lv Qingqing Dou Chunxia Li |
| author_sort | Luying Qiao |
| collection | DOAJ |
| description | Abstract Amyloid‐β (Aβ) and Tau proteins are the main components of Aβ plaques and neurofibrillary tangles in Alzheimer's disease (AD), and their abnormal aggregation is closely related to the pathogenesis of AD. The production of reactive oxygen species (ROS) and the aggregation of Aβ and Tau form a vicious circle, which leads to the aggravation of AD. However, inhibiting the aggregation of Aβ and Tau or scavenging ROS is not able to effectively reverse the progression of AD. Herein, we prepared a H2O2 responsive multifunctional nanocomposite UCNPs@mSiO2‐MB@AuNPs (abbreviated as USMA) to inhibit the aggregation of Aβ and Tau. In this system, USMA could respond to H2O2 to detach gold nanoparticles (AuNPs) and lead to the release of methylene blue (MB) from mesoporous silica (mSiO2), where AuNPs and MB can inhibit Aβ and Tau aggregation, respectively. Furthermore, USMA could consume H2O2 by reacting with them. Meanwhile, upconversion luminescence of UCNPs can be used to track USMA and monitor MB release, which could provide information on the content of MB in the lesion area. Importantly, the USMA can effectively reduce the cytotoxicity induced by Aβ and Tau aggregation. This work opens up a possibility to improve therapeutic efficacy for the treatment of AD. |
| first_indexed | 2024-03-13T00:33:21Z |
| format | Article |
| id | doaj.art-d64f774bbca24343ace70dac2bfe419d |
| institution | Directory Open Access Journal |
| issn | 2751-7446 |
| language | English |
| last_indexed | 2024-03-13T00:33:21Z |
| publishDate | 2023-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | BMEMat |
| spelling | doaj.art-d64f774bbca24343ace70dac2bfe419d2023-07-10T09:35:31ZengWileyBMEMat2751-74462023-03-0111n/an/a10.1002/bmm2.12011H2O2‐responsive multifunctional nanocomposite for the inhibition of amyloid‐β and Tau aggregation in Alzheimer's diseaseLuying Qiao0Yang Shen1Shiyu Zhang2Man Wang3Guanglei Lv4Qingqing Dou5Chunxia Li6Institute of Molecular Sciences and Engineering Institute of Frontier and Interdisciplinarity Science Shandong University Qingdao ChinaInstitute of Molecular Sciences and Engineering Institute of Frontier and Interdisciplinarity Science Shandong University Qingdao ChinaSchool of Environmental Science and Engineering Shandong University Qingdao ChinaInstitute of Molecular Sciences and Engineering Institute of Frontier and Interdisciplinarity Science Shandong University Qingdao ChinaCenter for Biotechnology and Biomedical Engineering Yiwu Research Institute of Fudan University Yiwu ChinaInstitute of Material Research & Engineering Agency for Science, Technology and Research (A*STAR) Singapore SingaporeInstitute of Molecular Sciences and Engineering Institute of Frontier and Interdisciplinarity Science Shandong University Qingdao ChinaAbstract Amyloid‐β (Aβ) and Tau proteins are the main components of Aβ plaques and neurofibrillary tangles in Alzheimer's disease (AD), and their abnormal aggregation is closely related to the pathogenesis of AD. The production of reactive oxygen species (ROS) and the aggregation of Aβ and Tau form a vicious circle, which leads to the aggravation of AD. However, inhibiting the aggregation of Aβ and Tau or scavenging ROS is not able to effectively reverse the progression of AD. Herein, we prepared a H2O2 responsive multifunctional nanocomposite UCNPs@mSiO2‐MB@AuNPs (abbreviated as USMA) to inhibit the aggregation of Aβ and Tau. In this system, USMA could respond to H2O2 to detach gold nanoparticles (AuNPs) and lead to the release of methylene blue (MB) from mesoporous silica (mSiO2), where AuNPs and MB can inhibit Aβ and Tau aggregation, respectively. Furthermore, USMA could consume H2O2 by reacting with them. Meanwhile, upconversion luminescence of UCNPs can be used to track USMA and monitor MB release, which could provide information on the content of MB in the lesion area. Importantly, the USMA can effectively reduce the cytotoxicity induced by Aβ and Tau aggregation. This work opens up a possibility to improve therapeutic efficacy for the treatment of AD.https://doi.org/10.1002/bmm2.12011Alzheimer's diseaseAmyloid‐βTauupconversion nanoparticles |
| spellingShingle | Luying Qiao Yang Shen Shiyu Zhang Man Wang Guanglei Lv Qingqing Dou Chunxia Li H2O2‐responsive multifunctional nanocomposite for the inhibition of amyloid‐β and Tau aggregation in Alzheimer's disease BMEMat Alzheimer's disease Amyloid‐β Tau upconversion nanoparticles |
| title | H2O2‐responsive multifunctional nanocomposite for the inhibition of amyloid‐β and Tau aggregation in Alzheimer's disease |
| title_full | H2O2‐responsive multifunctional nanocomposite for the inhibition of amyloid‐β and Tau aggregation in Alzheimer's disease |
| title_fullStr | H2O2‐responsive multifunctional nanocomposite for the inhibition of amyloid‐β and Tau aggregation in Alzheimer's disease |
| title_full_unstemmed | H2O2‐responsive multifunctional nanocomposite for the inhibition of amyloid‐β and Tau aggregation in Alzheimer's disease |
| title_short | H2O2‐responsive multifunctional nanocomposite for the inhibition of amyloid‐β and Tau aggregation in Alzheimer's disease |
| title_sort | h2o2 responsive multifunctional nanocomposite for the inhibition of amyloid β and tau aggregation in alzheimer s disease |
| topic | Alzheimer's disease Amyloid‐β Tau upconversion nanoparticles |
| url | https://doi.org/10.1002/bmm2.12011 |
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