How μ-opioid receptor recognizes fentanyl
Structures of mu-opioid receptor (mOR) in complex with morphine derivatives have been determined; but the structural basis of mOR activation by fentanyl-like synthetic opioids remains unclear. Here, authors use state-of-the-art simulation techniques and discover a secondary binding mode which is onl...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-02-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-21262-9 |
| _version_ | 1818691992380506112 |
|---|---|
| author | Quynh N. Vo Paween Mahinthichaichan Jana Shen Christopher R. Ellis |
| author_facet | Quynh N. Vo Paween Mahinthichaichan Jana Shen Christopher R. Ellis |
| author_sort | Quynh N. Vo |
| collection | DOAJ |
| description | Structures of mu-opioid receptor (mOR) in complex with morphine derivatives have been determined; but the structural basis of mOR activation by fentanyl-like synthetic opioids remains unclear. Here, authors use state-of-the-art simulation techniques and discover a secondary binding mode which is only accessible when the conserved His297 adopts a neutral HID tautomer state. |
| first_indexed | 2024-12-17T12:50:42Z |
| format | Article |
| id | doaj.art-d6525e7321244607a119714580e78d1a |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-17T12:50:42Z |
| publishDate | 2021-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-d6525e7321244607a119714580e78d1a2022-12-21T21:47:37ZengNature PortfolioNature Communications2041-17232021-02-0112111110.1038/s41467-021-21262-9How μ-opioid receptor recognizes fentanylQuynh N. Vo0Paween Mahinthichaichan1Jana Shen2Christopher R. Ellis3Center for Drug Evaluation and Research, United State Food and Drug AdministrationCenter for Drug Evaluation and Research, United State Food and Drug AdministrationDepartment of Pharmaceutical Sciences, University of Maryland School of PharmacyCenter for Drug Evaluation and Research, United State Food and Drug AdministrationStructures of mu-opioid receptor (mOR) in complex with morphine derivatives have been determined; but the structural basis of mOR activation by fentanyl-like synthetic opioids remains unclear. Here, authors use state-of-the-art simulation techniques and discover a secondary binding mode which is only accessible when the conserved His297 adopts a neutral HID tautomer state.https://doi.org/10.1038/s41467-021-21262-9 |
| spellingShingle | Quynh N. Vo Paween Mahinthichaichan Jana Shen Christopher R. Ellis How μ-opioid receptor recognizes fentanyl Nature Communications |
| title | How μ-opioid receptor recognizes fentanyl |
| title_full | How μ-opioid receptor recognizes fentanyl |
| title_fullStr | How μ-opioid receptor recognizes fentanyl |
| title_full_unstemmed | How μ-opioid receptor recognizes fentanyl |
| title_short | How μ-opioid receptor recognizes fentanyl |
| title_sort | how μ opioid receptor recognizes fentanyl |
| url | https://doi.org/10.1038/s41467-021-21262-9 |
| work_keys_str_mv | AT quynhnvo howmopioidreceptorrecognizesfentanyl AT paweenmahinthichaichan howmopioidreceptorrecognizesfentanyl AT janashen howmopioidreceptorrecognizesfentanyl AT christopherrellis howmopioidreceptorrecognizesfentanyl |