Anticoagulant, anti-inflammatory, antiviral and antitumor properties of heparins
Our knowledge regarding chemical structure and properties of heparin and its derivatives, including biological properties in blood plasma, on the cell surface and while interacting with receptors, has been progressively growing. New insights are followed by the expansion of therapeutic opportunities...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Jezik: | Russian |
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IRBIS LLC
2021-07-01
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| Serija: | Акушерство, гинекология и репродукция |
| Teme: | |
| Online dostop: | https://www.gynecology.su/jour/article/view/1010 |
| _version_ | 1826567117123616768 |
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| author | V. O. Bitsadze E. V. Slukhanchuk J. Kh. Khizroeva M. V. Tretyakova N. V. Pyatigorskaya S. V. Akinshina N. A. Makatsariya K. E. Gotsiridze N. N. Babaeva K. N. Grigoreva A. S. Shkoda I. Elalamy J.-C. Gris S. Shulman |
| author_facet | V. O. Bitsadze E. V. Slukhanchuk J. Kh. Khizroeva M. V. Tretyakova N. V. Pyatigorskaya S. V. Akinshina N. A. Makatsariya K. E. Gotsiridze N. N. Babaeva K. N. Grigoreva A. S. Shkoda I. Elalamy J.-C. Gris S. Shulman |
| author_sort | V. O. Bitsadze |
| collection | DOAJ |
| description | Our knowledge regarding chemical structure and properties of heparin and its derivatives, including biological properties in blood plasma, on the cell surface and while interacting with receptors, has been progressively growing. New insights are followed by the expansion of therapeutic opportunities and indications for the use of heparins. There are prerequisites for the creation of new generation drugs with modified properties that reduce a bleeding risk while applied for a non-anticoagulant goal. The non-anticoagulant heparin properties allow to consider it as a candidate for pathogenetic treatment of patients with COVID-19. This review focuses on the anticoagulant and non-anticoagulant heparin properties as well as the underlying molecular mechanisms. |
| first_indexed | 2024-04-10T04:02:06Z |
| format | Article |
| id | doaj.art-d654faae92e446029f925fc0c49d461f |
| institution | Directory Open Access Journal |
| issn | 2313-7347 2500-3194 |
| language | Russian |
| last_indexed | 2025-03-14T11:02:26Z |
| publishDate | 2021-07-01 |
| publisher | IRBIS LLC |
| record_format | Article |
| series | Акушерство, гинекология и репродукция |
| spelling | doaj.art-d654faae92e446029f925fc0c49d461f2025-03-02T10:43:06ZrusIRBIS LLCАкушерство, гинекология и репродукция2313-73472500-31942021-07-0115329531210.17749/2313-7347/ob.gyn.rep.2021.216654Anticoagulant, anti-inflammatory, antiviral and antitumor properties of heparinsV. O. Bitsadze0E. V. Slukhanchuk1J. Kh. Khizroeva2M. V. Tretyakova3N. V. Pyatigorskaya4S. V. Akinshina5N. A. Makatsariya6K. E. Gotsiridze7N. N. Babaeva8K. N. Grigoreva9A. S. Shkoda10I. Elalamy11J.-C. Gris12S. Shulman13Sechenov UniversityPetrovsky National Research Centre of SurgerySechenov University«Medical Center» LLCSechenov UniversitySechenov UniversitySechenov UniversityChachava Clinic«Altamed+» LLCSechenov UniversityVorokhobov City Clinical Hospital № 67, Moscow Healthcare DepartmentSechenov University; Medicine Sorbonne University; Hospital TenonSechenov University; University of MontpellierMcMaster University; Hamilton General Hospital; Karolinska InstituteOur knowledge regarding chemical structure and properties of heparin and its derivatives, including biological properties in blood plasma, on the cell surface and while interacting with receptors, has been progressively growing. New insights are followed by the expansion of therapeutic opportunities and indications for the use of heparins. There are prerequisites for the creation of new generation drugs with modified properties that reduce a bleeding risk while applied for a non-anticoagulant goal. The non-anticoagulant heparin properties allow to consider it as a candidate for pathogenetic treatment of patients with COVID-19. This review focuses on the anticoagulant and non-anticoagulant heparin properties as well as the underlying molecular mechanisms.https://www.gynecology.su/jour/article/view/1010heparinanticoagulantsmetastasesinflammationcovid-19 |
| spellingShingle | V. O. Bitsadze E. V. Slukhanchuk J. Kh. Khizroeva M. V. Tretyakova N. V. Pyatigorskaya S. V. Akinshina N. A. Makatsariya K. E. Gotsiridze N. N. Babaeva K. N. Grigoreva A. S. Shkoda I. Elalamy J.-C. Gris S. Shulman Anticoagulant, anti-inflammatory, antiviral and antitumor properties of heparins Акушерство, гинекология и репродукция heparin anticoagulants metastases inflammation covid-19 |
| title | Anticoagulant, anti-inflammatory, antiviral and antitumor properties of heparins |
| title_full | Anticoagulant, anti-inflammatory, antiviral and antitumor properties of heparins |
| title_fullStr | Anticoagulant, anti-inflammatory, antiviral and antitumor properties of heparins |
| title_full_unstemmed | Anticoagulant, anti-inflammatory, antiviral and antitumor properties of heparins |
| title_short | Anticoagulant, anti-inflammatory, antiviral and antitumor properties of heparins |
| title_sort | anticoagulant anti inflammatory antiviral and antitumor properties of heparins |
| topic | heparin anticoagulants metastases inflammation covid-19 |
| url | https://www.gynecology.su/jour/article/view/1010 |
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