Successful treatment of vaginal malakoplakia in a young cat
Case summary A 3-year-old, female, spayed, domestic shorthair cat presented for dysuria and haematuria, unresponsive to antibiotic treatment. A small, fleshy, erythematous mass protruded from the vaginal vault. Ultrasound identified a vaginal mass effect with mixed echogenicity measuring in excess o...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2016-10-01
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| Series: | Journal of Feline Medicine and Surgery Open Reports |
| Online Access: | https://doi.org/10.1177/2055116916674871 |
| _version_ | 1818268265464463360 |
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| author | Ryan P Cattin Michael R Hardcastle Kenneth W Simpson |
| author_facet | Ryan P Cattin Michael R Hardcastle Kenneth W Simpson |
| author_sort | Ryan P Cattin |
| collection | DOAJ |
| description | Case summary A 3-year-old, female, spayed, domestic shorthair cat presented for dysuria and haematuria, unresponsive to antibiotic treatment. A small, fleshy, erythematous mass protruded from the vaginal vault. Ultrasound identified a vaginal mass effect with mixed echogenicity measuring in excess of 3 cm. Vaginoscopy confirmed an extensive, fleshy, irregular mass that was characterised histologically as pyogranulomatous vaginitis, with periodic acid–Schiff-positive macrophages containing gram-negative bacteria. Fluorescence in situ hybridisation analysis demonstrated invasive intracellular Escherichia coli. Vaginal malakoplakia was diagnosed. Tissue culture and antimicrobial susceptibility of E coli was used to guide treatment. A 6 week course of enrofloxacin 5 mg/kg q24h resulted in complete resolution of the mass and clinical signs. Relevance and novel information Malakoplakia is a rare chronic inflammatory condition that has been previously reported in the bladder of two cats. The pathogenesis of malakoplakia is thought to involve ineffective killing of bacteria (eg. E coli ), similar to granulomatous colitis in Boxers and French Bulldogs. The literature on malakoplakia in cats is sparse. This is the first reported feline case with vaginal involvement, intracellular E coli and successful treatment with a fluoroquinolone. Malakoplakia is an important, non-neoplastic differential diagnosis when a mass is identified in the urogenital system of a young cat. |
| first_indexed | 2024-12-12T20:35:45Z |
| format | Article |
| id | doaj.art-d658e514da1045c0a98343eec55d0f2f |
| institution | Directory Open Access Journal |
| issn | 2055-1169 |
| language | English |
| last_indexed | 2024-12-12T20:35:45Z |
| publishDate | 2016-10-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of Feline Medicine and Surgery Open Reports |
| spelling | doaj.art-d658e514da1045c0a98343eec55d0f2f2022-12-22T00:12:55ZengSAGE PublishingJournal of Feline Medicine and Surgery Open Reports2055-11692016-10-01210.1177/205511691667487110.1177_2055116916674871Successful treatment of vaginal malakoplakia in a young catRyan P Cattin0Michael R Hardcastle1Kenneth W Simpson2Veterinary Specialist Group, Auckland, New ZealandGribbles Veterinary Pathology, Auckland, New ZealandCollege of Veterinary Medicine, Cornell University, USACase summary A 3-year-old, female, spayed, domestic shorthair cat presented for dysuria and haematuria, unresponsive to antibiotic treatment. A small, fleshy, erythematous mass protruded from the vaginal vault. Ultrasound identified a vaginal mass effect with mixed echogenicity measuring in excess of 3 cm. Vaginoscopy confirmed an extensive, fleshy, irregular mass that was characterised histologically as pyogranulomatous vaginitis, with periodic acid–Schiff-positive macrophages containing gram-negative bacteria. Fluorescence in situ hybridisation analysis demonstrated invasive intracellular Escherichia coli. Vaginal malakoplakia was diagnosed. Tissue culture and antimicrobial susceptibility of E coli was used to guide treatment. A 6 week course of enrofloxacin 5 mg/kg q24h resulted in complete resolution of the mass and clinical signs. Relevance and novel information Malakoplakia is a rare chronic inflammatory condition that has been previously reported in the bladder of two cats. The pathogenesis of malakoplakia is thought to involve ineffective killing of bacteria (eg. E coli ), similar to granulomatous colitis in Boxers and French Bulldogs. The literature on malakoplakia in cats is sparse. This is the first reported feline case with vaginal involvement, intracellular E coli and successful treatment with a fluoroquinolone. Malakoplakia is an important, non-neoplastic differential diagnosis when a mass is identified in the urogenital system of a young cat.https://doi.org/10.1177/2055116916674871 |
| spellingShingle | Ryan P Cattin Michael R Hardcastle Kenneth W Simpson Successful treatment of vaginal malakoplakia in a young cat Journal of Feline Medicine and Surgery Open Reports |
| title | Successful treatment of vaginal malakoplakia in a young cat |
| title_full | Successful treatment of vaginal malakoplakia in a young cat |
| title_fullStr | Successful treatment of vaginal malakoplakia in a young cat |
| title_full_unstemmed | Successful treatment of vaginal malakoplakia in a young cat |
| title_short | Successful treatment of vaginal malakoplakia in a young cat |
| title_sort | successful treatment of vaginal malakoplakia in a young cat |
| url | https://doi.org/10.1177/2055116916674871 |
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