Botulinum Toxin Treatment for Cancer-Related Disorders: A Systematic Review
This systematic review investigates the effect of botulinum neurotoxin (BoNT) therapy on cancer-related disorders. A major bulk of the literature is focused on BoNT’s effect on pain at the site of surgery or radiation. All 13 published studies on this issue indicated reduction or cessation of pain a...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-12-01
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| Series: | Toxins |
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| Online Access: | https://www.mdpi.com/2072-6651/15/12/689 |
| _version_ | 1797379252766638080 |
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| author | Delaram Safarpour Bahman Jabbari |
| author_facet | Delaram Safarpour Bahman Jabbari |
| author_sort | Delaram Safarpour |
| collection | DOAJ |
| description | This systematic review investigates the effect of botulinum neurotoxin (BoNT) therapy on cancer-related disorders. A major bulk of the literature is focused on BoNT’s effect on pain at the site of surgery or radiation. All 13 published studies on this issue indicated reduction or cessation of pain at these sites after local injection of BoNTs. Twelve studies addressed the effect of BoNT injection into the pylorus (sphincter between the stomach and the first part of the gut) for the prevention of gastroparesis after local resection of esophageal cancer. In eight studies, BoNT injection was superior to no intervention; three studies found no difference between the two approaches. One study compared the result of intra-pyloric BoNT injection with preventive pyloromyotomy (resection of pyloric muscle fibers). Both approaches reduced gastroparesis, but the surgical approach had more serious side effects. BoNT injection was superior to saline injection in the prevention of esophageal stricture after surgery (34% versus 6%, respectively, <i>p</i> = 0.02) and produced better results (30% versus 40% stricture) compared to steroid (triamcinolone) injection close to the surgical region. All 12 reported studies on the effect of BoNT injection into the parotid region for the reduction in facial sweating during eating (gustatory hyperhidrosis) found that BoNT injections stopped or significantly reduced facial sweating that developed after parotid gland surgery. Six studies showed that BoNT injection into the parotid region prevented the development of or healed the fistulas that developed after parotid gland resection—parotidectomy gustatory hyperhidrosis (Frey syndrome), post-surgical parotid fistula, and sialocele. Eight studies suggested that BoNT injection into masseter muscle reduced or stopped severe jaw pain after the first bite (first bite syndrome) that may develop as a complication of parotidectomy. |
| first_indexed | 2024-03-08T20:19:29Z |
| format | Article |
| id | doaj.art-d65974d70ffd48d9940a876faa1dff66 |
| institution | Directory Open Access Journal |
| issn | 2072-6651 |
| language | English |
| last_indexed | 2024-03-08T20:19:29Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxins |
| spelling | doaj.art-d65974d70ffd48d9940a876faa1dff662023-12-22T14:46:17ZengMDPI AGToxins2072-66512023-12-01151268910.3390/toxins15120689Botulinum Toxin Treatment for Cancer-Related Disorders: A Systematic ReviewDelaram Safarpour0Bahman Jabbari1Department of Neurology, Oregon Health & Science University, Portland, OR 97239, USADepartment of Neurology, Yale University School of Medicine, New Haven, CT 06510, USAThis systematic review investigates the effect of botulinum neurotoxin (BoNT) therapy on cancer-related disorders. A major bulk of the literature is focused on BoNT’s effect on pain at the site of surgery or radiation. All 13 published studies on this issue indicated reduction or cessation of pain at these sites after local injection of BoNTs. Twelve studies addressed the effect of BoNT injection into the pylorus (sphincter between the stomach and the first part of the gut) for the prevention of gastroparesis after local resection of esophageal cancer. In eight studies, BoNT injection was superior to no intervention; three studies found no difference between the two approaches. One study compared the result of intra-pyloric BoNT injection with preventive pyloromyotomy (resection of pyloric muscle fibers). Both approaches reduced gastroparesis, but the surgical approach had more serious side effects. BoNT injection was superior to saline injection in the prevention of esophageal stricture after surgery (34% versus 6%, respectively, <i>p</i> = 0.02) and produced better results (30% versus 40% stricture) compared to steroid (triamcinolone) injection close to the surgical region. All 12 reported studies on the effect of BoNT injection into the parotid region for the reduction in facial sweating during eating (gustatory hyperhidrosis) found that BoNT injections stopped or significantly reduced facial sweating that developed after parotid gland surgery. Six studies showed that BoNT injection into the parotid region prevented the development of or healed the fistulas that developed after parotid gland resection—parotidectomy gustatory hyperhidrosis (Frey syndrome), post-surgical parotid fistula, and sialocele. Eight studies suggested that BoNT injection into masseter muscle reduced or stopped severe jaw pain after the first bite (first bite syndrome) that may develop as a complication of parotidectomy.https://www.mdpi.com/2072-6651/15/12/689botulinum toxinbotulinum neurotoxincancerradiationpaingastroparesis |
| spellingShingle | Delaram Safarpour Bahman Jabbari Botulinum Toxin Treatment for Cancer-Related Disorders: A Systematic Review Toxins botulinum toxin botulinum neurotoxin cancer radiation pain gastroparesis |
| title | Botulinum Toxin Treatment for Cancer-Related Disorders: A Systematic Review |
| title_full | Botulinum Toxin Treatment for Cancer-Related Disorders: A Systematic Review |
| title_fullStr | Botulinum Toxin Treatment for Cancer-Related Disorders: A Systematic Review |
| title_full_unstemmed | Botulinum Toxin Treatment for Cancer-Related Disorders: A Systematic Review |
| title_short | Botulinum Toxin Treatment for Cancer-Related Disorders: A Systematic Review |
| title_sort | botulinum toxin treatment for cancer related disorders a systematic review |
| topic | botulinum toxin botulinum neurotoxin cancer radiation pain gastroparesis |
| url | https://www.mdpi.com/2072-6651/15/12/689 |
| work_keys_str_mv | AT delaramsafarpour botulinumtoxintreatmentforcancerrelateddisordersasystematicreview AT bahmanjabbari botulinumtoxintreatmentforcancerrelateddisordersasystematicreview |