Pharmacological Characterization of µ-Opioid Receptor Agonists with Biased G Protein or β-Arrestin Signaling, and Computational Study of Conformational Changes during Receptor Activation

Pharmacological Characterization of µ-Opioid Receptor Agonists with Biased G Protein or β-Arrestin Signaling, and Computational Study of Conformational Changes during Receptor Activation

In recent years, G protein vs. β-arrestin biased agonism at opioid receptors has been proposed as an opportunity to produce antinociception with reduced adverse effects. However, at present this approach is highly debated, a reason why more information about biased ligands is required. While the pra...

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Bibliographic Details
Main Authors: Justyna Piekielna-Ciesielska, Roberto Artali, Ammar A. H. Azzam, David G. Lambert, Alicja Kluczyk, Luca Gentilucci, Anna Janecka
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Molecules
Subjects:
opioid peptides
biased signaling
G-protein
β-arrestin
molecular modeling
Online Access:https://www.mdpi.com/1420-3049/26/1/13

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