Early switch from intravenous to oral antibiotic therapy in patients with cancer who have low-risk neutropenic sepsis: the EASI-SWITCH RCT

Early switch from intravenous to oral antibiotic therapy in patients with cancer who have low-risk neutropenic sepsis: the EASI-SWITCH RCT

Background Neutropenic sepsis is a common complication of systemic anticancer treatment. There is variation in practice in timing of switch to oral antibiotics after commencement of empirical intravenous antibiotic therapy. Objectives To establish the clinical and cost effectiveness of early switch...

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Bibliographic Details
Main Authors: Vicky Coyle, Caroline Forde, Richard Adams, Ashley Agus, Rosemary Barnes, Ian Chau, Mike Clarke, Annmarie Doran, Margaret Grayson, Danny McAuley, Cliona McDowell, Glenn Phair, Ruth Plummer, Dawn Storey, Anne Thomas, Richard Wilson, Ronan McMullan
Format: Article
Language:English
Published: NIHR Journals Library 2024-03-01
Series:Health Technology Assessment
Subjects:
ambulatory care
amoxicillin-potassium clavulanate combination
ciprofloxacin
cost–benefit analysis
duration of therapy
febrile neutropenia
guideline adherence
health resources
patient preference
piperacillin
tazobactam drug combination
risk factors
sepsis
treatment failure
pragmatic clinical trials as topic
Online Access:https://doi.org/10.3310/RGTP7112

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