Clinical and immunological characteristics of diabetes mellitus in patients with autoimmune polyglandular syndrome type 1 in Russia
Background. Autoimmune polyglandular syndrome type 1 (APS type 1) is a rare inherited autoimmune disease caused by mutations in AIRE gene (autoimmune regulator) and characterized by list of components. Diabetes mellitus (DM) can be one of components of this disease. Aims. To show frequency of DM in...
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| Format: | Article |
| Language: | English |
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Endocrinology Research Centre
2018-03-01
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| Series: | Сахарный диабет |
| Subjects: | |
| Online Access: | https://www.dia-endojournals.ru/jour/article/view/9347 |
| _version_ | 1797255173880414208 |
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| author | Leila S. Sozaeva Lubov I. Zilberman Galina N. Svetlova Ekaterina A. Andrianova Maria A. Kareva Olga N. Ivanova Svetlana M. Stepanova Larisa V. Savelyeva Alexandr Y. Mayorov Ekaterina A. Troshina Elizaveta M. Orlova Eystein S. Husebye Valentina A. Peterkova |
| author_facet | Leila S. Sozaeva Lubov I. Zilberman Galina N. Svetlova Ekaterina A. Andrianova Maria A. Kareva Olga N. Ivanova Svetlana M. Stepanova Larisa V. Savelyeva Alexandr Y. Mayorov Ekaterina A. Troshina Elizaveta M. Orlova Eystein S. Husebye Valentina A. Peterkova |
| author_sort | Leila S. Sozaeva |
| collection | DOAJ |
| description | Background. Autoimmune polyglandular syndrome type 1 (APS type 1) is a rare inherited autoimmune disease caused by mutations in AIRE gene (autoimmune regulator) and characterized by list of components. Diabetes mellitus (DM) can be one of components of this disease. Aims. To show frequency of DM in patients with APS type 1 in Russia, to describe clinical and immunological aspects of DM in patients with APS type 1 Materials and methods. 113 patients have been enrolled in the study, 16 of them had DM (15/16) or impaired glucose tolerance (1/16). Antibodies against glutamate decarboxylase, tyrosine phosphatase, zinc transporter-8, insulin and β-cells of pancreas were investigated in 30 patients with APS type 1 without DM and in 11 patients with APS type 1 and DM. ELISA test was used for detection autoantibodies. Results. Frequency of DM in patients with APS type 1 in Russia is 14.1% (16/113). Some patients had slow-progressive DM – 19%(3/16). Antibodies against insulin and β-cells were not specific and also were not sensitive markers for DM in APS type 1. Antibodies against tyrosine phosphatase and zinc transporter-8 test showed high specificity (100% и 97%), but low sensitivity (42% и 33,3%). Antibodies against glutamate decarboxylase were less specific (70%) and had very low sensitivity (58,3%). Conclusions. Frequency of DM in patients with APS type 1 in Russia is high to compare to other countries. 20% of Russian patients had slow-progressive course of DM. Antibodies against tyrosine phosphatase and zinc transporter-8 were the most specific for DM in patients with APS type 1, but sensitivity of these antibodies was low. |
| first_indexed | 2024-03-08T15:20:41Z |
| format | Article |
| id | doaj.art-d65b388c5d854351b4a44c51cabd9441 |
| institution | Directory Open Access Journal |
| issn | 2072-0351 2072-0378 |
| language | English |
| last_indexed | 2024-04-24T22:01:39Z |
| publishDate | 2018-03-01 |
| publisher | Endocrinology Research Centre |
| record_format | Article |
| series | Сахарный диабет |
| spelling | doaj.art-d65b388c5d854351b4a44c51cabd94412024-03-20T11:48:01ZengEndocrinology Research CentreСахарный диабет2072-03512072-03782018-03-01211485710.14341/DM93478429Clinical and immunological characteristics of diabetes mellitus in patients with autoimmune polyglandular syndrome type 1 in RussiaLeila S. Sozaeva0Lubov I. Zilberman1Galina N. Svetlova2Ekaterina A. Andrianova3Maria A. Kareva4Olga N. Ivanova5Svetlana M. Stepanova6Larisa V. Savelyeva7Alexandr Y. Mayorov8Ekaterina A. Troshina9Elizaveta M. Orlova10Eystein S. Husebye11Valentina A. Peterkova12<p>Endocrinology Research Centre</p><p>Endocrinology Research Centre</p><p>Endocrinology Research Centre</p><p>Endocrinology Research Centre</p><p>Endocrinology Research Centre</p><p>Endocrinology Research Centre</p><p>Endocrinology Research Centre</p><p>Endocrinology Research Centre</p><p>Endocrinology Research Centre</p><p>Endocrinology Research Centre</p><p>Endocrinology Research Centre</p><p>University of Bergen</p><p>Endocrinology Research Centre</p>Background. Autoimmune polyglandular syndrome type 1 (APS type 1) is a rare inherited autoimmune disease caused by mutations in AIRE gene (autoimmune regulator) and characterized by list of components. Diabetes mellitus (DM) can be one of components of this disease. Aims. To show frequency of DM in patients with APS type 1 in Russia, to describe clinical and immunological aspects of DM in patients with APS type 1 Materials and methods. 113 patients have been enrolled in the study, 16 of them had DM (15/16) or impaired glucose tolerance (1/16). Antibodies against glutamate decarboxylase, tyrosine phosphatase, zinc transporter-8, insulin and β-cells of pancreas were investigated in 30 patients with APS type 1 without DM and in 11 patients with APS type 1 and DM. ELISA test was used for detection autoantibodies. Results. Frequency of DM in patients with APS type 1 in Russia is 14.1% (16/113). Some patients had slow-progressive DM – 19%(3/16). Antibodies against insulin and β-cells were not specific and also were not sensitive markers for DM in APS type 1. Antibodies against tyrosine phosphatase and zinc transporter-8 test showed high specificity (100% и 97%), but low sensitivity (42% и 33,3%). Antibodies against glutamate decarboxylase were less specific (70%) and had very low sensitivity (58,3%). Conclusions. Frequency of DM in patients with APS type 1 in Russia is high to compare to other countries. 20% of Russian patients had slow-progressive course of DM. Antibodies against tyrosine phosphatase and zinc transporter-8 were the most specific for DM in patients with APS type 1, but sensitivity of these antibodies was low.https://www.dia-endojournals.ru/jour/article/view/9347autoimmune polyglandular syndrome type 1airediabetes mellitusantibodiesglutamate decarboxylasetyrosine phosphatasezinc transporter-8insulinβ-cells of pancreas |
| spellingShingle | Leila S. Sozaeva Lubov I. Zilberman Galina N. Svetlova Ekaterina A. Andrianova Maria A. Kareva Olga N. Ivanova Svetlana M. Stepanova Larisa V. Savelyeva Alexandr Y. Mayorov Ekaterina A. Troshina Elizaveta M. Orlova Eystein S. Husebye Valentina A. Peterkova Clinical and immunological characteristics of diabetes mellitus in patients with autoimmune polyglandular syndrome type 1 in Russia Сахарный диабет autoimmune polyglandular syndrome type 1 aire diabetes mellitus antibodies glutamate decarboxylase tyrosine phosphatase zinc transporter-8 insulin β-cells of pancreas |
| title | Clinical and immunological characteristics of diabetes mellitus in patients with autoimmune polyglandular syndrome type 1 in Russia |
| title_full | Clinical and immunological characteristics of diabetes mellitus in patients with autoimmune polyglandular syndrome type 1 in Russia |
| title_fullStr | Clinical and immunological characteristics of diabetes mellitus in patients with autoimmune polyglandular syndrome type 1 in Russia |
| title_full_unstemmed | Clinical and immunological characteristics of diabetes mellitus in patients with autoimmune polyglandular syndrome type 1 in Russia |
| title_short | Clinical and immunological characteristics of diabetes mellitus in patients with autoimmune polyglandular syndrome type 1 in Russia |
| title_sort | clinical and immunological characteristics of diabetes mellitus in patients with autoimmune polyglandular syndrome type 1 in russia |
| topic | autoimmune polyglandular syndrome type 1 aire diabetes mellitus antibodies glutamate decarboxylase tyrosine phosphatase zinc transporter-8 insulin β-cells of pancreas |
| url | https://www.dia-endojournals.ru/jour/article/view/9347 |
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