Possible Transmission Flow of SARS-CoV-2 Based on ACE2 Features
Angiotensin-converting enzyme 2 (ACE2) is the cellular receptor for the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) that is engendering the severe coronavirus disease 2019 (COVID-19) pandemic. The spike (S) protein receptor-binding domain (RBD) of SARS-CoV-2 binds to the three sub-d...
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| Format: | Article |
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MDPI AG
2020-12-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/25/24/5906 |
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| author | Sk. Sarif Hassan Shinjini Ghosh Diksha Attrish Pabitra Pal Choudhury Alaa A. A. Aljabali Bruce D. Uhal Kenneth Lundstrom Nima Rezaei Vladimir N. Uversky Murat Seyran Damiano Pizzol Parise Adadi Antonio Soares Tarek Mohamed Abd El-Aziz Ramesh Kandimalla Murtaza M. Tambuwala Gajendra Kumar Azad Samendra P. Sherchan Wagner Baetas-da-Cruz Kazuo Takayama Ángel Serrano-Aroca Gaurav Chauhan Giorgio Palu Adam M. Brufsky |
| author_facet | Sk. Sarif Hassan Shinjini Ghosh Diksha Attrish Pabitra Pal Choudhury Alaa A. A. Aljabali Bruce D. Uhal Kenneth Lundstrom Nima Rezaei Vladimir N. Uversky Murat Seyran Damiano Pizzol Parise Adadi Antonio Soares Tarek Mohamed Abd El-Aziz Ramesh Kandimalla Murtaza M. Tambuwala Gajendra Kumar Azad Samendra P. Sherchan Wagner Baetas-da-Cruz Kazuo Takayama Ángel Serrano-Aroca Gaurav Chauhan Giorgio Palu Adam M. Brufsky |
| author_sort | Sk. Sarif Hassan |
| collection | DOAJ |
| description | Angiotensin-converting enzyme 2 (ACE2) is the cellular receptor for the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) that is engendering the severe coronavirus disease 2019 (COVID-19) pandemic. The spike (S) protein receptor-binding domain (RBD) of SARS-CoV-2 binds to the three sub-domains viz. amino acids (aa) 22–42, aa 79–84, and aa 330–393 of ACE2 on human cells to initiate entry. It was reported earlier that the receptor utilization capacity of ACE2 proteins from different species, such as cats, chimpanzees, dogs, and cattle, are different. A comprehensive analysis of ACE2 receptors of nineteen species was carried out in this study, and the findings propose a possible SARS-CoV-2 transmission flow across these nineteen species. |
| first_indexed | 2024-03-10T14:06:18Z |
| format | Article |
| id | doaj.art-d65c5b3319374864b2787c170fbfdcf3 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T14:06:18Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-d65c5b3319374864b2787c170fbfdcf32023-11-21T00:37:47ZengMDPI AGMolecules1420-30492020-12-012524590610.3390/molecules25245906Possible Transmission Flow of SARS-CoV-2 Based on ACE2 FeaturesSk. Sarif Hassan0Shinjini Ghosh1Diksha Attrish2Pabitra Pal Choudhury3Alaa A. A. Aljabali4Bruce D. Uhal5Kenneth Lundstrom6Nima Rezaei7Vladimir N. Uversky8Murat Seyran9Damiano Pizzol10Parise Adadi11Antonio Soares12Tarek Mohamed Abd El-Aziz13Ramesh Kandimalla14Murtaza M. Tambuwala15Gajendra Kumar Azad16Samendra P. Sherchan17Wagner Baetas-da-Cruz18Kazuo Takayama19Ángel Serrano-Aroca20Gaurav Chauhan21Giorgio Palu22Adam M. Brufsky23Department of Mathematics, Pingla Thana Mahavidyalaya, Maligram 721140, IndiaDepartment of Biophysics, Molecular Biology and Bioinformatics, University of Calcutta, Kolkata 700009, IndiaDr. B. R. Ambedkar Centre for Biomedical Research (ACBR), University of Delhi (North Campus), Delhi 110007, IndiaApplied Statistics Unit, Indian Statistical Institute, Kolkata 700108, West Bengal, IndiaDepartment of Pharmaceutics and Pharmaceutical Technology, Yarmouk University-Faculty of Pharmacy, Irbid 566, JordanDepartment of Physiology, Michigan State University, East Lansing, MI 48824, USAPanTherapeutics, Rte de Lavaux 49, CH1095 Lutry, SwitzerlandResearch Center for Immunodeficiencies, Pediatrics Center of Excellence, Children’s Medical Center, Tehran University of Medical Sciences, Tehran 1416753955, IranDepartment of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USADoctoral studies in natural and technical sciences (SPL 44), University of Vienna, 1010 Wien, AustriaItalian Agency for Development Cooperation—Khartoum, Sudan Street 33, Al Amarat, Khartoum 825109, SudanDepartment of Food Science, University of Otago, Dunedin 9054, New ZealandDepartment of Cellular and Integrative Physiology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 77030, USADepartment of Cellular and Integrative Physiology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 77030, USAApplied Biology, CSIR-Indian Institute of Chemical Technology Uppal Road, Tarnaka, Hyderabad 500007, IndiaSchool of Pharmacy and Pharmaceutical Science, Ulster University, Coleraine BT52 1SA, Northern Ireland, UKDepartment of Zoology, Patna University, Patna, Bihar 800005, IndiaDepartment of Environmental Health Sciences, Tulane University, New Orleans, LA 70112, USATranslational Laboratory in Molecular Physiology, Centre for Experimental Surgery, College of Medicine, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro 21941901, BrazilCenter for iPS Cell Research and Application, Kyoto University, Kyoto 606-8501, JapanBiomaterials and Bioengineering Lab, Translational Research Centre San Alberto Magno, Catholic University of Valencia San Vicente Mártir, c/Guillem de Castro 94, 46001 Valencia, SpainSchool of Engineering and Sciences, Tecnologico de Monterrey, Av. Eugenio Garza Sada 2501 Sur, Monterrey 64849, Nuevo León, MexicoDepartment of Molecular Medicine, University of Padova, Via Gabelli 63, 35121 Padova, ItalyDivision of Hematology/Oncology, Department of Medicine, UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USAAngiotensin-converting enzyme 2 (ACE2) is the cellular receptor for the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) that is engendering the severe coronavirus disease 2019 (COVID-19) pandemic. The spike (S) protein receptor-binding domain (RBD) of SARS-CoV-2 binds to the three sub-domains viz. amino acids (aa) 22–42, aa 79–84, and aa 330–393 of ACE2 on human cells to initiate entry. It was reported earlier that the receptor utilization capacity of ACE2 proteins from different species, such as cats, chimpanzees, dogs, and cattle, are different. A comprehensive analysis of ACE2 receptors of nineteen species was carried out in this study, and the findings propose a possible SARS-CoV-2 transmission flow across these nineteen species.https://www.mdpi.com/1420-3049/25/24/5906ACE2viral spike receptor-binding domainSARS-CoV-2transmissionbioinformatics |
| spellingShingle | Sk. Sarif Hassan Shinjini Ghosh Diksha Attrish Pabitra Pal Choudhury Alaa A. A. Aljabali Bruce D. Uhal Kenneth Lundstrom Nima Rezaei Vladimir N. Uversky Murat Seyran Damiano Pizzol Parise Adadi Antonio Soares Tarek Mohamed Abd El-Aziz Ramesh Kandimalla Murtaza M. Tambuwala Gajendra Kumar Azad Samendra P. Sherchan Wagner Baetas-da-Cruz Kazuo Takayama Ángel Serrano-Aroca Gaurav Chauhan Giorgio Palu Adam M. Brufsky Possible Transmission Flow of SARS-CoV-2 Based on ACE2 Features Molecules ACE2 viral spike receptor-binding domain SARS-CoV-2 transmission bioinformatics |
| title | Possible Transmission Flow of SARS-CoV-2 Based on ACE2 Features |
| title_full | Possible Transmission Flow of SARS-CoV-2 Based on ACE2 Features |
| title_fullStr | Possible Transmission Flow of SARS-CoV-2 Based on ACE2 Features |
| title_full_unstemmed | Possible Transmission Flow of SARS-CoV-2 Based on ACE2 Features |
| title_short | Possible Transmission Flow of SARS-CoV-2 Based on ACE2 Features |
| title_sort | possible transmission flow of sars cov 2 based on ace2 features |
| topic | ACE2 viral spike receptor-binding domain SARS-CoV-2 transmission bioinformatics |
| url | https://www.mdpi.com/1420-3049/25/24/5906 |
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