Higher Number of EBI3 Cells in Mucosal Chronic Hyperplastic Candidiasis May Serve to Regulate IL-17-Producing Cells
Previous research into the inflammatory cell infiltrate of chronic hyperplastic candidosis (CHC) determined that the immune response is primarily composed of T cells, the majority of which are T helper (CD4<sup>+</sup>) cells. This present investigation used immunohistochemistry to furth...
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| Format: | Article |
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MDPI AG
2021-06-01
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| Series: | Journal of Fungi |
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| Online Access: | https://www.mdpi.com/2309-608X/7/7/533 |
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| author | Ailish Williams Helen Rogers David Williams Xiao-Qing Wei Damian Farnell Sue Wozniak Adam Jones |
| author_facet | Ailish Williams Helen Rogers David Williams Xiao-Qing Wei Damian Farnell Sue Wozniak Adam Jones |
| author_sort | Ailish Williams |
| collection | DOAJ |
| description | Previous research into the inflammatory cell infiltrate of chronic hyperplastic candidosis (CHC) determined that the immune response is primarily composed of T cells, the majority of which are T helper (CD4<sup>+</sup>) cells. This present investigation used immunohistochemistry to further delineate the inflammatory cell infiltrate in CHC. Cells profiled were those expressing IL-17A cytokine, EBI3 and IL-12A subunits of the IL-35 cytokine, and FoxP3<sup>+</sup> cells. Squamous cell papilloma (with <i>Candida</i> infection) and oral lichen planus tissues served as comparative controls to understand the local immune responses to <i>Candida</i> infection. The results demonstrated that <i>Candida</i>-induced inflammation and immune regulation co-exist in the oral mucosa of CHC and that high prevalence of cells expressing the EBI3 cytokine subunit may play an important role in this regulation. This balance between inflammation and immune tolerance toward invading <i>Candida</i> in the oral mucosa may be critical in determining progress of infection. |
| first_indexed | 2024-03-10T09:54:11Z |
| format | Article |
| id | doaj.art-d65f98e3755f4e2cbea0c7bfacd63030 |
| institution | Directory Open Access Journal |
| issn | 2309-608X |
| language | English |
| last_indexed | 2024-03-10T09:54:11Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Fungi |
| spelling | doaj.art-d65f98e3755f4e2cbea0c7bfacd630302023-11-22T02:32:18ZengMDPI AGJournal of Fungi2309-608X2021-06-017753310.3390/jof7070533Higher Number of EBI3 Cells in Mucosal Chronic Hyperplastic Candidiasis May Serve to Regulate IL-17-Producing CellsAilish Williams0Helen Rogers1David Williams2Xiao-Qing Wei3Damian Farnell4Sue Wozniak5Adam Jones6School of Dentistry, Cardiff University, Heath Park, Cardiff CF14 4XY, UKBristol Dental School, Lower Maudlin Street, Bristol BS1 3NU, UKSchool of Dentistry, Cardiff University, Heath Park, Cardiff CF14 4XY, UKSchool of Dentistry, Cardiff University, Heath Park, Cardiff CF14 4XY, UKSchool of Dentistry, Cardiff University, Heath Park, Cardiff CF14 4XY, UKDental Hospital, University Hospital of Wales, Heath Park, Cardiff CF14 4XY, UKDental Hospital, University Hospital of Wales, Heath Park, Cardiff CF14 4XY, UKPrevious research into the inflammatory cell infiltrate of chronic hyperplastic candidosis (CHC) determined that the immune response is primarily composed of T cells, the majority of which are T helper (CD4<sup>+</sup>) cells. This present investigation used immunohistochemistry to further delineate the inflammatory cell infiltrate in CHC. Cells profiled were those expressing IL-17A cytokine, EBI3 and IL-12A subunits of the IL-35 cytokine, and FoxP3<sup>+</sup> cells. Squamous cell papilloma (with <i>Candida</i> infection) and oral lichen planus tissues served as comparative controls to understand the local immune responses to <i>Candida</i> infection. The results demonstrated that <i>Candida</i>-induced inflammation and immune regulation co-exist in the oral mucosa of CHC and that high prevalence of cells expressing the EBI3 cytokine subunit may play an important role in this regulation. This balance between inflammation and immune tolerance toward invading <i>Candida</i> in the oral mucosa may be critical in determining progress of infection.https://www.mdpi.com/2309-608X/7/7/533inflammatory cellschronic hyperplastic candidosisimmunohistochemistrycytokines |
| spellingShingle | Ailish Williams Helen Rogers David Williams Xiao-Qing Wei Damian Farnell Sue Wozniak Adam Jones Higher Number of EBI3 Cells in Mucosal Chronic Hyperplastic Candidiasis May Serve to Regulate IL-17-Producing Cells Journal of Fungi inflammatory cells chronic hyperplastic candidosis immunohistochemistry cytokines |
| title | Higher Number of EBI3 Cells in Mucosal Chronic Hyperplastic Candidiasis May Serve to Regulate IL-17-Producing Cells |
| title_full | Higher Number of EBI3 Cells in Mucosal Chronic Hyperplastic Candidiasis May Serve to Regulate IL-17-Producing Cells |
| title_fullStr | Higher Number of EBI3 Cells in Mucosal Chronic Hyperplastic Candidiasis May Serve to Regulate IL-17-Producing Cells |
| title_full_unstemmed | Higher Number of EBI3 Cells in Mucosal Chronic Hyperplastic Candidiasis May Serve to Regulate IL-17-Producing Cells |
| title_short | Higher Number of EBI3 Cells in Mucosal Chronic Hyperplastic Candidiasis May Serve to Regulate IL-17-Producing Cells |
| title_sort | higher number of ebi3 cells in mucosal chronic hyperplastic candidiasis may serve to regulate il 17 producing cells |
| topic | inflammatory cells chronic hyperplastic candidosis immunohistochemistry cytokines |
| url | https://www.mdpi.com/2309-608X/7/7/533 |
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