Total syntheses of shizukaols A and E

Shizukaols, bioactive dimers naturally occurring in the Chloranthaceae family, possess a complex polycyclic framework with more than ten contiguous stereocenters. Here the authors report the total syntheses of shizukaols A and E achieved via a modified Diels–Alder reaction mimicking the biosynthetic...

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Main Authors: Jian-Li Wu, Yin-Suo Lu, Bencan Tang, Xiao-Shui Peng
Format: Article
Language:English
Published: Nature Portfolio 2018-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-06245-7
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author Jian-Li Wu
Yin-Suo Lu
Bencan Tang
Xiao-Shui Peng
author_facet Jian-Li Wu
Yin-Suo Lu
Bencan Tang
Xiao-Shui Peng
author_sort Jian-Li Wu
collection DOAJ
description Shizukaols, bioactive dimers naturally occurring in the Chloranthaceae family, possess a complex polycyclic framework with more than ten contiguous stereocenters. Here the authors report the total syntheses of shizukaols A and E achieved via a modified Diels–Alder reaction mimicking the biosynthetic pathway.
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spelling doaj.art-d6608fe0878048248a3f11a12a24dd562022-12-21T19:10:52ZengNature PortfolioNature Communications2041-17232018-10-01911710.1038/s41467-018-06245-7Total syntheses of shizukaols A and EJian-Li Wu0Yin-Suo Lu1Bencan Tang2Xiao-Shui Peng3Department of Chemistry, and State Key Laboratory of Synthetic Chemistry, The Chinese University of Hong KongDepartment of Chemistry, and State Key Laboratory of Synthetic Chemistry, The Chinese University of Hong KongDepartment of Chemical and Environmental Engineering, The University of Nottingham Ningbo ChinaDepartment of Chemistry, and State Key Laboratory of Synthetic Chemistry, The Chinese University of Hong KongShizukaols, bioactive dimers naturally occurring in the Chloranthaceae family, possess a complex polycyclic framework with more than ten contiguous stereocenters. Here the authors report the total syntheses of shizukaols A and E achieved via a modified Diels–Alder reaction mimicking the biosynthetic pathway.https://doi.org/10.1038/s41467-018-06245-7
spellingShingle Jian-Li Wu
Yin-Suo Lu
Bencan Tang
Xiao-Shui Peng
Total syntheses of shizukaols A and E
Nature Communications
title Total syntheses of shizukaols A and E
title_full Total syntheses of shizukaols A and E
title_fullStr Total syntheses of shizukaols A and E
title_full_unstemmed Total syntheses of shizukaols A and E
title_short Total syntheses of shizukaols A and E
title_sort total syntheses of shizukaols a and e
url https://doi.org/10.1038/s41467-018-06245-7
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AT bencantang totalsynthesesofshizukaolsaande
AT xiaoshuipeng totalsynthesesofshizukaolsaande