PINK1 regulates apoptosis of osteosarcoma as the target gene of cisplatin

PINK1 regulates apoptosis of osteosarcoma as the target gene of cisplatin

Abstract Background Osteosarcoma is a common primary bone malignancy prevalent among adolescents and young adults. PTEN-induced kinase 1 (PINK1) regulates Parkinson's disease, but its role in cancers is unknown. Objective This study was designed to analyze the mechanism by which PINK1 affects o...

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Bibliographic Details
Main Authors: Zhenxing Si, Zilong Shen, Feiyu Luan, Jinglong Yan
Format: Article
Language:English
Published: BMC 2023-02-01
Series:Journal of Orthopaedic Surgery and Research
Subjects:
Osteosarcoma
PINK1
FOXO3a
Apoptosis
Cisplatin
Online Access:https://doi.org/10.1186/s13018-023-03615-w

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