Tumor infiltrating lymphocytes in malignant melanoma - allies or foes?
This is an overview of current problematics regarding the role of tumor infiltrating lymphocytes (TILs) in malignant melanomas. Various and often conflicting data have been published, correlating tumor type, stage, prognosis, as well as sex and age of patients. This is partly due to heterogeneity in...
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| Format: | Article |
| Language: | English |
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Palacký University Olomouc, Faculty of Medicine and Dentistry
2020-03-01
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| Series: | Biomedical Papers |
| Subjects: | |
| Online Access: | https://biomed.papers.upol.cz/artkey/bio-202001-0004_tumor-infiltrating-lymphocytes-in-malignant-melanoma-allies-or-foes.php |
| _version_ | 1828481932379291648 |
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| author | Vladimir Zidlik Michala Bezdekova Svetlana Brychtova |
| author_facet | Vladimir Zidlik Michala Bezdekova Svetlana Brychtova |
| author_sort | Vladimir Zidlik |
| collection | DOAJ |
| description | This is an overview of current problematics regarding the role of tumor infiltrating lymphocytes (TILs) in malignant melanomas. Various and often conflicting data have been published, correlating tumor type, stage, prognosis, as well as sex and age of patients. This is partly due to heterogeneity in scaling systems and unstandardized TILs grading but also due to changes of tumor-host interactions. Melanomas are an immunologically heterogeneous group with variability of TILs, where distinct gene expression patterns were found in tumors with absent, and/or non- brisk TIL grade versus brisk TIL grade. However, the presence of TILs alone appears to be inadequate for implicating them as immunologically functional. Further characterisation of TIL phenotype and function is warranted. This especially concerns, evaluation of TILs of the suppressor phenotype but rather than as a prognostic factor, more for prediction of targeted immunotherapy. |
| first_indexed | 2024-12-11T08:04:38Z |
| format | Article |
| id | doaj.art-d6637c71daf045898401a00d07751b4a |
| institution | Directory Open Access Journal |
| issn | 1213-8118 1804-7521 |
| language | English |
| last_indexed | 2024-12-11T08:04:38Z |
| publishDate | 2020-03-01 |
| publisher | Palacký University Olomouc, Faculty of Medicine and Dentistry |
| record_format | Article |
| series | Biomedical Papers |
| spelling | doaj.art-d6637c71daf045898401a00d07751b4a2022-12-22T01:15:01ZengPalacký University Olomouc, Faculty of Medicine and DentistryBiomedical Papers1213-81181804-75212020-03-011641434810.5507/bp.2019.048bio-202001-0004Tumor infiltrating lymphocytes in malignant melanoma - allies or foes?Vladimir Zidlik0Michala Bezdekova1Svetlana Brychtova2Department of Pathology, University Hospital Ostrava, Czech RepublicInstitute of Clinical and Molecular Pathology, University Hospital Olomouc, Olomouc, Czech RepublicInstitute of Clinical and Molecular Pathology, University Hospital Olomouc, Olomouc, Czech RepublicThis is an overview of current problematics regarding the role of tumor infiltrating lymphocytes (TILs) in malignant melanomas. Various and often conflicting data have been published, correlating tumor type, stage, prognosis, as well as sex and age of patients. This is partly due to heterogeneity in scaling systems and unstandardized TILs grading but also due to changes of tumor-host interactions. Melanomas are an immunologically heterogeneous group with variability of TILs, where distinct gene expression patterns were found in tumors with absent, and/or non- brisk TIL grade versus brisk TIL grade. However, the presence of TILs alone appears to be inadequate for implicating them as immunologically functional. Further characterisation of TIL phenotype and function is warranted. This especially concerns, evaluation of TILs of the suppressor phenotype but rather than as a prognostic factor, more for prediction of targeted immunotherapy.https://biomed.papers.upol.cz/artkey/bio-202001-0004_tumor-infiltrating-lymphocytes-in-malignant-melanoma-allies-or-foes.phpmelanomatumor infiltrating lymphocytesregulatory lymphocytesimmune check point |
| spellingShingle | Vladimir Zidlik Michala Bezdekova Svetlana Brychtova Tumor infiltrating lymphocytes in malignant melanoma - allies or foes? Biomedical Papers melanoma tumor infiltrating lymphocytes regulatory lymphocytes immune check point |
| title | Tumor infiltrating lymphocytes in malignant melanoma - allies or foes? |
| title_full | Tumor infiltrating lymphocytes in malignant melanoma - allies or foes? |
| title_fullStr | Tumor infiltrating lymphocytes in malignant melanoma - allies or foes? |
| title_full_unstemmed | Tumor infiltrating lymphocytes in malignant melanoma - allies or foes? |
| title_short | Tumor infiltrating lymphocytes in malignant melanoma - allies or foes? |
| title_sort | tumor infiltrating lymphocytes in malignant melanoma allies or foes |
| topic | melanoma tumor infiltrating lymphocytes regulatory lymphocytes immune check point |
| url | https://biomed.papers.upol.cz/artkey/bio-202001-0004_tumor-infiltrating-lymphocytes-in-malignant-melanoma-allies-or-foes.php |
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