Transcriptional adaptation of staphylococci during colonization of the authentic human environment: An overview of transcriptomic changes and their relationship to physiological conditions
Staphylococci are commensals of human skin and mucous membranes, but some species can also cause serious infections. Host niches during both colonization and infection differ greatly and are characterized by specific environmental conditions (pH, temperature, oxygen, nutrient availability, and micro...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2022.1062329/full |
| _version_ | 1811224692810317824 |
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| author | Marc Burian Christiane Wolz Christiane Wolz Amir S. Yazdi |
| author_facet | Marc Burian Christiane Wolz Christiane Wolz Amir S. Yazdi |
| author_sort | Marc Burian |
| collection | DOAJ |
| description | Staphylococci are commensals of human skin and mucous membranes, but some species can also cause serious infections. Host niches during both colonization and infection differ greatly and are characterized by specific environmental conditions (pH, temperature, oxygen, nutrient availability, and microbiota) that can affect gene expression and virulence of microbes. To successfully occupy extremely different habitats at different anatomical sites, Staphylococci are equipped with a variety of regulatory elements that allow specific adaptation to the changing environments. Not surprisingly, gene expression in vivo can be significantly different from the expression pattern observed in vitro. Niche specific stimuli that influence the bacterial ability to either cause infection or maintain colonization are only partially understood. Here, we describe habitat specific conditions and discuss the available literature analyzing staphylococcal gene expression, focusing on Staphylococcus aureus and S. epidermidis during colonization of the nose and skin. |
| first_indexed | 2024-04-12T08:53:17Z |
| format | Article |
| id | doaj.art-d66635208f5e45ffb123cdbe7f0b89dd |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-04-12T08:53:17Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-d66635208f5e45ffb123cdbe7f0b89dd2022-12-22T03:39:32ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882022-11-011210.3389/fcimb.2022.10623291062329Transcriptional adaptation of staphylococci during colonization of the authentic human environment: An overview of transcriptomic changes and their relationship to physiological conditionsMarc Burian0Christiane Wolz1Christiane Wolz2Amir S. Yazdi3Department of Dermatology and Allergology, RWTH University Hospital Aachen, Aachen, GermanyInterfaculty Institute of Microbiology and Infection Medicine, University of Tübingen, Tübingen, GermanyCluster of Excellence EXC 2124 “Controlling Microbes to Fight Infections”, University of Tübingen, Tübingen, GermanyDepartment of Dermatology and Allergology, RWTH University Hospital Aachen, Aachen, GermanyStaphylococci are commensals of human skin and mucous membranes, but some species can also cause serious infections. Host niches during both colonization and infection differ greatly and are characterized by specific environmental conditions (pH, temperature, oxygen, nutrient availability, and microbiota) that can affect gene expression and virulence of microbes. To successfully occupy extremely different habitats at different anatomical sites, Staphylococci are equipped with a variety of regulatory elements that allow specific adaptation to the changing environments. Not surprisingly, gene expression in vivo can be significantly different from the expression pattern observed in vitro. Niche specific stimuli that influence the bacterial ability to either cause infection or maintain colonization are only partially understood. Here, we describe habitat specific conditions and discuss the available literature analyzing staphylococcal gene expression, focusing on Staphylococcus aureus and S. epidermidis during colonization of the nose and skin.https://www.frontiersin.org/articles/10.3389/fcimb.2022.1062329/fullbacterial adaptationgene expressionin vivoglobal regulatorsnasal colonizationskin colonization |
| spellingShingle | Marc Burian Christiane Wolz Christiane Wolz Amir S. Yazdi Transcriptional adaptation of staphylococci during colonization of the authentic human environment: An overview of transcriptomic changes and their relationship to physiological conditions Frontiers in Cellular and Infection Microbiology bacterial adaptation gene expression in vivo global regulators nasal colonization skin colonization |
| title | Transcriptional adaptation of staphylococci during colonization of the authentic human environment: An overview of transcriptomic changes and their relationship to physiological conditions |
| title_full | Transcriptional adaptation of staphylococci during colonization of the authentic human environment: An overview of transcriptomic changes and their relationship to physiological conditions |
| title_fullStr | Transcriptional adaptation of staphylococci during colonization of the authentic human environment: An overview of transcriptomic changes and their relationship to physiological conditions |
| title_full_unstemmed | Transcriptional adaptation of staphylococci during colonization of the authentic human environment: An overview of transcriptomic changes and their relationship to physiological conditions |
| title_short | Transcriptional adaptation of staphylococci during colonization of the authentic human environment: An overview of transcriptomic changes and their relationship to physiological conditions |
| title_sort | transcriptional adaptation of staphylococci during colonization of the authentic human environment an overview of transcriptomic changes and their relationship to physiological conditions |
| topic | bacterial adaptation gene expression in vivo global regulators nasal colonization skin colonization |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2022.1062329/full |
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