Increased Calbindin D28k Expression via Long-Term Alternate-Day Fasting Does Not Protect against Ischemia-Reperfusion Injury: A Focus on Delayed Neuronal Death, Gliosis and Immunoglobulin G Leakage

Increased Calbindin D28k Expression via Long-Term Alternate-Day Fasting Does Not Protect against Ischemia-Reperfusion Injury: A Focus on Delayed Neuronal Death, Gliosis and Immunoglobulin G Leakage

Calbindin-D28k (CB), a calcium-binding protein, mediates diverse neuronal functions. In this study, adult gerbils were fed a normal diet (ND) or exposed to intermittent fasting (IF) for three months, and were randomly assigned to sham or ischemia operated groups. Ischemic injury was induced by trans...

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Bibliographic Details
Main Authors: Hyejin Sim, Tae-Kyeong Lee, Yeon Ho Yoo, Ji Hyeon Ahn, Dae Won Kim, Bora Kim, Jae-Chul Lee, Joon Ha Park, Soon-Sung Lim, Jung-Seok Park, Il Jun Kang, Young-Myeong Kim, Myoung Cheol Shin, Jun Hwi Cho, Yoonsoo Park, Moo-Ho Won
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:International Journal of Molecular Sciences
Subjects:
intermittent fasting
ischemia-reperfusion
calcium binding protein
hippocampal CA1 region
pyramidal neurons
Online Access:https://www.mdpi.com/1422-0067/22/2/644

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