Clinical impact of parental consanguineous marriage in idiopathic nonobstructive azoospermia
Objective: To determine the frequency of parental consanguineous marriages (PCMs) in men with diagnosed idiopathic nonobstructive azoospermia (INOA) and to compare clinical and pathological parameters between azoospermic men with and without PCM. Design: Retrospective. Setting: A private clinic. Pat...
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| Format: | Article |
| Language: | English |
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Elsevier
2020-12-01
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| Series: | F&S Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666334120300416 |
| _version_ | 1818336742533496832 |
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| author | Oktay Özman, M.D. Mustafa Emre Bakırcıoğlu, M.D. |
| author_facet | Oktay Özman, M.D. Mustafa Emre Bakırcıoğlu, M.D. |
| author_sort | Oktay Özman, M.D. |
| collection | DOAJ |
| description | Objective: To determine the frequency of parental consanguineous marriages (PCMs) in men with diagnosed idiopathic nonobstructive azoospermia (INOA) and to compare clinical and pathological parameters between azoospermic men with and without PCM. Design: Retrospective. Setting: A private clinic. Patient(s): Two hundred forty-six men with INOA. Patients were divided into two groups: group 1 with PCM and group 2 without PCM. Clinical parameters, surgical sperm retrieval rates, and pathological findings were compared between the groups. Intervention(s): Surgical sperm retrieval. Main Outcome Measure(s): PCM and clinical parameters. Result(s): Among the 246 patients with INOA, 81 had PCM. Men with PCM had lower follicle-stimulating hormone (13.7 vs. 21.9 mIU/mL), higher testosterone (3.8 vs. 3.4 ng/mL), and larger testes (14.1 vs. 11.8 mL). In parallel with the clinical findings, the most common pathological pattern in men with PCM was maturation arrest. However, there was no difference in surgical sperm retrieval rate between men with (23.4%) and without (32.1%) PCM. Conclusion(s): Our data showed that PCM was present for 33% of men with INOA. The clinical parameters of men with PCM and INOA were significantly different than those without PCM, primarily demonstrating maturation arrest in testicular pathology. Further genetic research in families who have infertile male siblings may elucidate underlying rare genetic abnormalities in spermatogenesis. |
| first_indexed | 2024-12-13T14:44:09Z |
| format | Article |
| id | doaj.art-d6679cd4acdf476d81c51883e63faacc |
| institution | Directory Open Access Journal |
| issn | 2666-3341 |
| language | English |
| last_indexed | 2024-12-13T14:44:09Z |
| publishDate | 2020-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | F&S Reports |
| spelling | doaj.art-d6679cd4acdf476d81c51883e63faacc2022-12-21T23:41:31ZengElsevierF&S Reports2666-33412020-12-0113209212Clinical impact of parental consanguineous marriage in idiopathic nonobstructive azoospermiaOktay Özman, M.D.0Mustafa Emre Bakırcıoğlu, M.D.1Health Sciences University, Gaziosmanpaşa Education and Research Hospital, Urology Clinic, Istanbul, TurkeyIstanbul Florence Nightingale Hospital, Urology, Istanbul, Turkey; Reprint requests: Mustafa Emre Bakırcıoğlu, Associate Professor, Unimed Center, Hakki Yeten Caddesi No. 19 Kat 4 Fulya, 34365 Istanbul, Turkey.Objective: To determine the frequency of parental consanguineous marriages (PCMs) in men with diagnosed idiopathic nonobstructive azoospermia (INOA) and to compare clinical and pathological parameters between azoospermic men with and without PCM. Design: Retrospective. Setting: A private clinic. Patient(s): Two hundred forty-six men with INOA. Patients were divided into two groups: group 1 with PCM and group 2 without PCM. Clinical parameters, surgical sperm retrieval rates, and pathological findings were compared between the groups. Intervention(s): Surgical sperm retrieval. Main Outcome Measure(s): PCM and clinical parameters. Result(s): Among the 246 patients with INOA, 81 had PCM. Men with PCM had lower follicle-stimulating hormone (13.7 vs. 21.9 mIU/mL), higher testosterone (3.8 vs. 3.4 ng/mL), and larger testes (14.1 vs. 11.8 mL). In parallel with the clinical findings, the most common pathological pattern in men with PCM was maturation arrest. However, there was no difference in surgical sperm retrieval rate between men with (23.4%) and without (32.1%) PCM. Conclusion(s): Our data showed that PCM was present for 33% of men with INOA. The clinical parameters of men with PCM and INOA were significantly different than those without PCM, primarily demonstrating maturation arrest in testicular pathology. Further genetic research in families who have infertile male siblings may elucidate underlying rare genetic abnormalities in spermatogenesis.http://www.sciencedirect.com/science/article/pii/S2666334120300416Idiopathic nonobstructive azoospermiamale infertilityparental consanguineous marriage |
| spellingShingle | Oktay Özman, M.D. Mustafa Emre Bakırcıoğlu, M.D. Clinical impact of parental consanguineous marriage in idiopathic nonobstructive azoospermia F&S Reports Idiopathic nonobstructive azoospermia male infertility parental consanguineous marriage |
| title | Clinical impact of parental consanguineous marriage in idiopathic nonobstructive azoospermia |
| title_full | Clinical impact of parental consanguineous marriage in idiopathic nonobstructive azoospermia |
| title_fullStr | Clinical impact of parental consanguineous marriage in idiopathic nonobstructive azoospermia |
| title_full_unstemmed | Clinical impact of parental consanguineous marriage in idiopathic nonobstructive azoospermia |
| title_short | Clinical impact of parental consanguineous marriage in idiopathic nonobstructive azoospermia |
| title_sort | clinical impact of parental consanguineous marriage in idiopathic nonobstructive azoospermia |
| topic | Idiopathic nonobstructive azoospermia male infertility parental consanguineous marriage |
| url | http://www.sciencedirect.com/science/article/pii/S2666334120300416 |
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