Roflumilast Powders for Chronic Obstructive Pulmonary Disease: Formulation Design and the Influence of Device, Inhalation Flow Rate, and Storage Relative Humidity on Aerosolization

Roflumilast Powders for Chronic Obstructive Pulmonary Disease: Formulation Design and the Influence of Device, Inhalation Flow Rate, and Storage Relative Humidity on Aerosolization

Roflumilast is currently administered orally to control acute exacerbations in chronic obstructive pulmonary disease (COPD). However, side effects such as gastrointestinal disturbance and weight loss have limited its application. This work aimed to develop an inhalable roflumilast formulation to red...

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Bibliographic Details
Main Authors: Mohammad A. M. Momin, Bishal Raj Adhikari, Shubhra Sinha, Ian Larson, Shyamal C. Das
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Pharmaceutics
Subjects:
roflumilast
L-leucine
trehalose
chronic obstructive pulmonary disease
dry powder
Online Access:https://www.mdpi.com/1999-4923/13/8/1254

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