Orally Administered 6:2 Chlorinated Polyfluorinated Ether Sulfonate (F-53B) Causes Thyroid Dysfunction in Rats
The compound 6:2 chlorinated polyfluorinated ether sulfonate (F-53B), a replacement for perfluorooctanesulfonate (PFOS) in the electroplating industry, has been widely detected in numerous environmental matrices, human sera, and organisms. Due to regulations that limit PFOS use, F-53B use is expecte...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-08-01
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| Series: | Toxics |
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| Online Access: | https://www.mdpi.com/2305-6304/8/3/54 |
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| author | So-Hye Hong Seung Hee Lee Jun-Young Yang Jin Hee Lee Ki Kyung Jung Ji Hyun Seok Sung-Hee Kim Ki Taek Nam Jayoung Jeong Jong Kwon Lee Jae-Ho Oh |
| author_facet | So-Hye Hong Seung Hee Lee Jun-Young Yang Jin Hee Lee Ki Kyung Jung Ji Hyun Seok Sung-Hee Kim Ki Taek Nam Jayoung Jeong Jong Kwon Lee Jae-Ho Oh |
| author_sort | So-Hye Hong |
| collection | DOAJ |
| description | The compound 6:2 chlorinated polyfluorinated ether sulfonate (F-53B), a replacement for perfluorooctanesulfonate (PFOS) in the electroplating industry, has been widely detected in numerous environmental matrices, human sera, and organisms. Due to regulations that limit PFOS use, F-53B use is expected to increase. Therefore, in this study, we performed a subchronic oral toxicity study of F-53B in Sprague Dawley (SD) rats. F-53B was administered orally once daily to male and female rats for 28 days at doses of 5, 20, and 100 mg/kg/day. There were no toxicologically significant changes in F-53B-treated rats, except in the thyroid gland. However, F-53B slightly reduced the serum concentrations of thyroid hormones, including triiodothyronine and thyroxine, compared with their concentrations in the vehicle group. F-53B also induced follicular hyperplasia and was associated with increased thyroid hormone biosynthesis-associated protein expression. These results demonstrate that F-53B is a strong regulator of thyroid hormones in SD rats as it disrupts thyroid function. Thus, caution should be exercised in the industrial application of F-53B as an alternative for PFOS. |
| first_indexed | 2024-03-10T17:46:17Z |
| format | Article |
| id | doaj.art-d66ab86cc9aa4029910d6b1a04261844 |
| institution | Directory Open Access Journal |
| issn | 2305-6304 |
| language | English |
| last_indexed | 2024-03-10T17:46:17Z |
| publishDate | 2020-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxics |
| spelling | doaj.art-d66ab86cc9aa4029910d6b1a042618442023-11-20T09:32:06ZengMDPI AGToxics2305-63042020-08-01835410.3390/toxics8030054Orally Administered 6:2 Chlorinated Polyfluorinated Ether Sulfonate (F-53B) Causes Thyroid Dysfunction in RatsSo-Hye Hong0Seung Hee Lee1Jun-Young Yang2Jin Hee Lee3Ki Kyung Jung4Ji Hyun Seok5Sung-Hee Kim6Ki Taek Nam7Jayoung Jeong8Jong Kwon Lee9Jae-Ho Oh10Toxicological Research Division, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety, Osong, Chungcheongbuk-do 28159, KoreaToxicological Research Division, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety, Osong, Chungcheongbuk-do 28159, KoreaToxicological Research Division, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety, Osong, Chungcheongbuk-do 28159, KoreaToxicological Research Division, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety, Osong, Chungcheongbuk-do 28159, KoreaToxicological Research Division, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety, Osong, Chungcheongbuk-do 28159, KoreaToxicological Research Division, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety, Osong, Chungcheongbuk-do 28159, KoreaSeverance Biomedical Science Institute, College of Medicine, Yonsei University, Seoul 03760, KoreaSeverance Biomedical Science Institute, College of Medicine, Yonsei University, Seoul 03760, KoreaToxicological Research Division, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety, Osong, Chungcheongbuk-do 28159, KoreaToxicological Research Division, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety, Osong, Chungcheongbuk-do 28159, KoreaToxicological Research Division, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety, Osong, Chungcheongbuk-do 28159, KoreaThe compound 6:2 chlorinated polyfluorinated ether sulfonate (F-53B), a replacement for perfluorooctanesulfonate (PFOS) in the electroplating industry, has been widely detected in numerous environmental matrices, human sera, and organisms. Due to regulations that limit PFOS use, F-53B use is expected to increase. Therefore, in this study, we performed a subchronic oral toxicity study of F-53B in Sprague Dawley (SD) rats. F-53B was administered orally once daily to male and female rats for 28 days at doses of 5, 20, and 100 mg/kg/day. There were no toxicologically significant changes in F-53B-treated rats, except in the thyroid gland. However, F-53B slightly reduced the serum concentrations of thyroid hormones, including triiodothyronine and thyroxine, compared with their concentrations in the vehicle group. F-53B also induced follicular hyperplasia and was associated with increased thyroid hormone biosynthesis-associated protein expression. These results demonstrate that F-53B is a strong regulator of thyroid hormones in SD rats as it disrupts thyroid function. Thus, caution should be exercised in the industrial application of F-53B as an alternative for PFOS.https://www.mdpi.com/2305-6304/8/3/54F-53Bsubchronic oral toxicitythyroid hormonethyroid dysfunction |
| spellingShingle | So-Hye Hong Seung Hee Lee Jun-Young Yang Jin Hee Lee Ki Kyung Jung Ji Hyun Seok Sung-Hee Kim Ki Taek Nam Jayoung Jeong Jong Kwon Lee Jae-Ho Oh Orally Administered 6:2 Chlorinated Polyfluorinated Ether Sulfonate (F-53B) Causes Thyroid Dysfunction in Rats Toxics F-53B subchronic oral toxicity thyroid hormone thyroid dysfunction |
| title | Orally Administered 6:2 Chlorinated Polyfluorinated Ether Sulfonate (F-53B) Causes Thyroid Dysfunction in Rats |
| title_full | Orally Administered 6:2 Chlorinated Polyfluorinated Ether Sulfonate (F-53B) Causes Thyroid Dysfunction in Rats |
| title_fullStr | Orally Administered 6:2 Chlorinated Polyfluorinated Ether Sulfonate (F-53B) Causes Thyroid Dysfunction in Rats |
| title_full_unstemmed | Orally Administered 6:2 Chlorinated Polyfluorinated Ether Sulfonate (F-53B) Causes Thyroid Dysfunction in Rats |
| title_short | Orally Administered 6:2 Chlorinated Polyfluorinated Ether Sulfonate (F-53B) Causes Thyroid Dysfunction in Rats |
| title_sort | orally administered 6 2 chlorinated polyfluorinated ether sulfonate f 53b causes thyroid dysfunction in rats |
| topic | F-53B subchronic oral toxicity thyroid hormone thyroid dysfunction |
| url | https://www.mdpi.com/2305-6304/8/3/54 |
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