Management of Double Sensitization to Vespids in Europe
Wasp allergy with a diagnostic profile of double sensitizations to vespid venom is a frequent clinical problem in areas where different genera of wasps are present. Identification of the insect responsible for serious reactions poses a diagnostic challenge as the only effective treatment to date is...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-02-01
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| Series: | Toxins |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6651/14/2/126 |
| _version_ | 1797476287815614464 |
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| author | Berta Ruiz-Leon Pilar Serrano Carmen Vidal Carmen Moreno-Aguilar |
| author_facet | Berta Ruiz-Leon Pilar Serrano Carmen Vidal Carmen Moreno-Aguilar |
| author_sort | Berta Ruiz-Leon |
| collection | DOAJ |
| description | Wasp allergy with a diagnostic profile of double sensitizations to vespid venom is a frequent clinical problem in areas where different genera of wasps are present. Identification of the insect responsible for serious reactions poses a diagnostic challenge as the only effective treatment to date is immunotherapy based on the specific venom. In southern Europe, the double sensitization to <i>Vespula</i> and <i>Polistes</i> venoms is highly frequent. It has been shown that the major allergenic proteins (Phospholipase A1 and Antigen 5) share sequences across the different genera and species, which would be the cause of cross-reactivity. Additionally, the minor allergens (Dipeptidyl-peptidases, Vitellogenins) have been found to share partial sequence identity. Furthermore, venom contains other homologous proteins whose allergenic nature still remains to be clarified. The traditional diagnostic tools available are insufficient to discriminate between allergy to <i>Vespula</i> and <i>Polistes</i> in a high number of cases. IgE inhibition is the technique that best identifies the cross-reactivity. When a double sensitization has indeed been shown to exist or great uncertainty surrounds the primary sensitization, therapy with two venoms is advisable to guarantee the safety of the patient. In this case, a strategy involving alternate administration that combines effectiveness with efficiency is possible. |
| first_indexed | 2024-03-09T20:55:53Z |
| format | Article |
| id | doaj.art-d66b13de41534dbab4e64317e73ad583 |
| institution | Directory Open Access Journal |
| issn | 2072-6651 |
| language | English |
| last_indexed | 2024-03-09T20:55:53Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxins |
| spelling | doaj.art-d66b13de41534dbab4e64317e73ad5832023-11-23T22:21:48ZengMDPI AGToxins2072-66512022-02-0114212610.3390/toxins14020126Management of Double Sensitization to Vespids in EuropeBerta Ruiz-Leon0Pilar Serrano1Carmen Vidal2Carmen Moreno-Aguilar3Allergy Section of University Hospital Reina Sofia-IMIBIC, ARADyAL Network, National Institute of Health Carlos III, 14005 Cordoba, SpainAllergy Section of University Hospital Reina Sofia-IMIBIC, ARADyAL Network, National Institute of Health Carlos III, 14005 Cordoba, SpainAllergy Department of Complejo Hospitalario Universitario de Santiago de Compostela, 15706 Santiago de Compostela, SpainAllergy Section of University Hospital Reina Sofia-IMIBIC, ARADyAL Network, National Institute of Health Carlos III, 14005 Cordoba, SpainWasp allergy with a diagnostic profile of double sensitizations to vespid venom is a frequent clinical problem in areas where different genera of wasps are present. Identification of the insect responsible for serious reactions poses a diagnostic challenge as the only effective treatment to date is immunotherapy based on the specific venom. In southern Europe, the double sensitization to <i>Vespula</i> and <i>Polistes</i> venoms is highly frequent. It has been shown that the major allergenic proteins (Phospholipase A1 and Antigen 5) share sequences across the different genera and species, which would be the cause of cross-reactivity. Additionally, the minor allergens (Dipeptidyl-peptidases, Vitellogenins) have been found to share partial sequence identity. Furthermore, venom contains other homologous proteins whose allergenic nature still remains to be clarified. The traditional diagnostic tools available are insufficient to discriminate between allergy to <i>Vespula</i> and <i>Polistes</i> in a high number of cases. IgE inhibition is the technique that best identifies the cross-reactivity. When a double sensitization has indeed been shown to exist or great uncertainty surrounds the primary sensitization, therapy with two venoms is advisable to guarantee the safety of the patient. In this case, a strategy involving alternate administration that combines effectiveness with efficiency is possible.https://www.mdpi.com/2072-6651/14/2/126<i>Vespula</i><i>Polistes</i>allergensdouble sensitization to vespidscross-reactivityvenom immunotherapy |
| spellingShingle | Berta Ruiz-Leon Pilar Serrano Carmen Vidal Carmen Moreno-Aguilar Management of Double Sensitization to Vespids in Europe Toxins <i>Vespula</i> <i>Polistes</i> allergens double sensitization to vespids cross-reactivity venom immunotherapy |
| title | Management of Double Sensitization to Vespids in Europe |
| title_full | Management of Double Sensitization to Vespids in Europe |
| title_fullStr | Management of Double Sensitization to Vespids in Europe |
| title_full_unstemmed | Management of Double Sensitization to Vespids in Europe |
| title_short | Management of Double Sensitization to Vespids in Europe |
| title_sort | management of double sensitization to vespids in europe |
| topic | <i>Vespula</i> <i>Polistes</i> allergens double sensitization to vespids cross-reactivity venom immunotherapy |
| url | https://www.mdpi.com/2072-6651/14/2/126 |
| work_keys_str_mv | AT bertaruizleon managementofdoublesensitizationtovespidsineurope AT pilarserrano managementofdoublesensitizationtovespidsineurope AT carmenvidal managementofdoublesensitizationtovespidsineurope AT carmenmorenoaguilar managementofdoublesensitizationtovespidsineurope |