A Multivalent Vaccine Containing Actinobacillus pleuropneumoniae and Mycoplasma hyopneumoniae Antigens Elicits Strong Immune Responses and Promising Protection in Pigs
Actinobacillus pleuropneumoniae (App) and Mycoplasma hyopneumoniae (Mhp) cause porcine pleuropneumonia and mycoplasmal pneumonia, respectively, and have serious impacts on the swine industry because they retard the growth of pigs. To protect pigs against these diseases, we have developed a multivale...
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| Format: | Article |
| Language: | English |
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Journal of Pure and Applied Microbiology
2021-03-01
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| Series: | Journal of Pure and Applied Microbiology |
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| Online Access: | https://microbiologyjournal.org/a-multivalent-vaccine-containing-actinobacillus-pleuropneumoniae-and-mycoplasma-hyopneumoniae-antigens-elicits-strong-immune-responses-and-promising-protection-in-pigs/ |
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| author | Hoai Thu Dao Woo-Sung Shin Van Tan Do Quang Lam Truong Jong-Young Choi Tae-Wook Hahn |
| author_facet | Hoai Thu Dao Woo-Sung Shin Van Tan Do Quang Lam Truong Jong-Young Choi Tae-Wook Hahn |
| author_sort | Hoai Thu Dao |
| collection | DOAJ |
| description | Actinobacillus pleuropneumoniae (App) and Mycoplasma hyopneumoniae (Mhp) cause porcine pleuropneumonia and mycoplasmal pneumonia, respectively, and have serious impacts on the swine industry because they retard the growth of pigs. To protect pigs against these diseases, we have developed a multivalent vaccine consisting of App bacterins, APP RTX toxins (Apx toxins), and Mhp bacterin and adhesin protein. This vaccine induced the production of higher levels of antibodies against App and Mhp than the commercial vaccine (Nisseiken Swine APM Inactivated Vaccine). Furthermore, the vaccine efficiently protected pigs against virulent App challenge, showing promise as an efficient vaccine for the prevention of two important respiratory diseases, porcine pleuropneumonia and mycoplasmal pneumonia. |
| first_indexed | 2024-12-22T10:47:35Z |
| format | Article |
| id | doaj.art-d66b3feac23e45b9aa67ff06da886ff1 |
| institution | Directory Open Access Journal |
| issn | 0973-7510 2581-690X |
| language | English |
| last_indexed | 2024-12-22T10:47:35Z |
| publishDate | 2021-03-01 |
| publisher | Journal of Pure and Applied Microbiology |
| record_format | Article |
| series | Journal of Pure and Applied Microbiology |
| spelling | doaj.art-d66b3feac23e45b9aa67ff06da886ff12022-12-21T18:28:54ZengJournal of Pure and Applied MicrobiologyJournal of Pure and Applied Microbiology0973-75102581-690X2021-03-0115116417410.22207/JPAM.15.1.11A Multivalent Vaccine Containing Actinobacillus pleuropneumoniae and Mycoplasma hyopneumoniae Antigens Elicits Strong Immune Responses and Promising Protection in PigsHoai Thu Daohttps://orcid.org/0000-0002-2797-9955Woo-Sung Shinhttps://orcid.org/0000-0001-9061-7458Van Tan Dohttps://orcid.org/0000-0003-4512-7622Quang Lam Truonghttps://orcid.org/0000-0002-9403-2614Jong-Young Choihttps://orcid.org/0000-0002-2382-0701Tae-Wook Hahnhttps://orcid.org/0000-0002-3919-1153Actinobacillus pleuropneumoniae (App) and Mycoplasma hyopneumoniae (Mhp) cause porcine pleuropneumonia and mycoplasmal pneumonia, respectively, and have serious impacts on the swine industry because they retard the growth of pigs. To protect pigs against these diseases, we have developed a multivalent vaccine consisting of App bacterins, APP RTX toxins (Apx toxins), and Mhp bacterin and adhesin protein. This vaccine induced the production of higher levels of antibodies against App and Mhp than the commercial vaccine (Nisseiken Swine APM Inactivated Vaccine). Furthermore, the vaccine efficiently protected pigs against virulent App challenge, showing promise as an efficient vaccine for the prevention of two important respiratory diseases, porcine pleuropneumonia and mycoplasmal pneumonia.https://microbiologyjournal.org/a-multivalent-vaccine-containing-actinobacillus-pleuropneumoniae-and-mycoplasma-hyopneumoniae-antigens-elicits-strong-immune-responses-and-promising-protection-in-pigs/actinobacillus pleuropneumoniaemycoplasma hyopneumoniaemultivalent vaccineimmune responsesprotection efficacy |
| spellingShingle | Hoai Thu Dao Woo-Sung Shin Van Tan Do Quang Lam Truong Jong-Young Choi Tae-Wook Hahn A Multivalent Vaccine Containing Actinobacillus pleuropneumoniae and Mycoplasma hyopneumoniae Antigens Elicits Strong Immune Responses and Promising Protection in Pigs Journal of Pure and Applied Microbiology actinobacillus pleuropneumoniae mycoplasma hyopneumoniae multivalent vaccine immune responses protection efficacy |
| title | A Multivalent Vaccine Containing Actinobacillus pleuropneumoniae and Mycoplasma hyopneumoniae Antigens Elicits Strong Immune Responses and Promising Protection in Pigs |
| title_full | A Multivalent Vaccine Containing Actinobacillus pleuropneumoniae and Mycoplasma hyopneumoniae Antigens Elicits Strong Immune Responses and Promising Protection in Pigs |
| title_fullStr | A Multivalent Vaccine Containing Actinobacillus pleuropneumoniae and Mycoplasma hyopneumoniae Antigens Elicits Strong Immune Responses and Promising Protection in Pigs |
| title_full_unstemmed | A Multivalent Vaccine Containing Actinobacillus pleuropneumoniae and Mycoplasma hyopneumoniae Antigens Elicits Strong Immune Responses and Promising Protection in Pigs |
| title_short | A Multivalent Vaccine Containing Actinobacillus pleuropneumoniae and Mycoplasma hyopneumoniae Antigens Elicits Strong Immune Responses and Promising Protection in Pigs |
| title_sort | multivalent vaccine containing actinobacillus pleuropneumoniae and mycoplasma hyopneumoniae antigens elicits strong immune responses and promising protection in pigs |
| topic | actinobacillus pleuropneumoniae mycoplasma hyopneumoniae multivalent vaccine immune responses protection efficacy |
| url | https://microbiologyjournal.org/a-multivalent-vaccine-containing-actinobacillus-pleuropneumoniae-and-mycoplasma-hyopneumoniae-antigens-elicits-strong-immune-responses-and-promising-protection-in-pigs/ |
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