Central adiposity increases the odds for plasma folate deficiency among Chinese women of reproductive age
ObjectiveTo explore the association between adiposity and plasma folate deficiency odds among women of reproductive age in China.MethodsA cross-sectional survey on nutritional status among women of reproductive aged 18–30 years in 2005–2006 in China was conducted. General adiposity was defined as bo...
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Public Health |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2022.1000542/full |
| _version_ | 1811241486074773504 |
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| author | Jinjuan Zhang Jinjuan Zhang Jinjuan Zhang Yushan Du Yushan Du Xiaoyu Che Xiaoyu Che Shuangbo Xia Shuangbo Xia Le Zhang Le Zhang Jufen Liu Jufen Liu |
| author_facet | Jinjuan Zhang Jinjuan Zhang Jinjuan Zhang Yushan Du Yushan Du Xiaoyu Che Xiaoyu Che Shuangbo Xia Shuangbo Xia Le Zhang Le Zhang Jufen Liu Jufen Liu |
| author_sort | Jinjuan Zhang |
| collection | DOAJ |
| description | ObjectiveTo explore the association between adiposity and plasma folate deficiency odds among women of reproductive age in China.MethodsA cross-sectional survey on nutritional status among women of reproductive aged 18–30 years in 2005–2006 in China was conducted. General adiposity was defined as body mass index (BMI) ≥24 kg/m2, and central adiposity was defined as waist circumference >80 cm. A plasma folate concentration <10.5 nmol/L (measured through microbiological assay) was defined as plasma folate deficiency. Odds ratios (ORs) and 95% confidence intervals (CIs) for plasma folate deficiency were calculated using a logistic regression model, with adjustment for potential confounders.ResultsA total of 3,076 women of reproductive age were included in the final analysis. Compared to women with normal BMI and WC, women with both general and central adiposity had the highest odds for plasma folate deficiency (OR = 3.107, 95% CI: 1.819–5.307). Women with exclusively central adiposity had excess odds for plasma folate deficiency (WC > 80 cm, BMI <24 kg/m2; OR = 2.448, 95% CI: 1.144–5.241), which was higher than women with exclusively general adiposity (BMI ≥ 24 kg/m2, WC ≤ 80 cm; OR = 1.709, 95% CI: 1.259–2.319). The combined use of BMI and WC can detect more women (11.7%) at higher plasma folate deficiency odds than either used alone.ConclusionsWomen with central adiposity in normal weight have higher odds for plasma folate deficiency than those with general obesity only. Early screening for central adiposity among women of reproductive age would be meaningful to prevent folate deficiency and improve life-cycle health. |
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| institution | Directory Open Access Journal |
| issn | 2296-2565 |
| language | English |
| last_indexed | 2024-04-12T13:36:53Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Public Health |
| spelling | doaj.art-d66c0ae1f58249f29960c6c2b142751a2022-12-22T03:30:58ZengFrontiers Media S.A.Frontiers in Public Health2296-25652022-10-011010.3389/fpubh.2022.10005421000542Central adiposity increases the odds for plasma folate deficiency among Chinese women of reproductive ageJinjuan Zhang0Jinjuan Zhang1Jinjuan Zhang2Yushan Du3Yushan Du4Xiaoyu Che5Xiaoyu Che6Shuangbo Xia7Shuangbo Xia8Le Zhang9Le Zhang10Jufen Liu11Jufen Liu12Department of Critical Care Medicine, Peking University People's Hospital, Beijing, ChinaInstitute of Reproductive and Child Health/National Health Commission Key Laboratory of Reproductive Health, Peking University, Beijing, ChinaDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, ChinaInstitute of Reproductive and Child Health/National Health Commission Key Laboratory of Reproductive Health, Peking University, Beijing, ChinaDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, ChinaInstitute of Reproductive and Child Health/National Health Commission Key Laboratory of Reproductive Health, Peking University, Beijing, ChinaDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, ChinaInstitute of Reproductive and Child Health/National Health Commission Key Laboratory of Reproductive Health, Peking University, Beijing, ChinaDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, ChinaInstitute of Reproductive and Child Health/National Health Commission Key Laboratory of Reproductive Health, Peking University, Beijing, ChinaDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, ChinaInstitute of Reproductive and Child Health/National Health Commission Key Laboratory of Reproductive Health, Peking University, Beijing, ChinaDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, ChinaObjectiveTo explore the association between adiposity and plasma folate deficiency odds among women of reproductive age in China.MethodsA cross-sectional survey on nutritional status among women of reproductive aged 18–30 years in 2005–2006 in China was conducted. General adiposity was defined as body mass index (BMI) ≥24 kg/m2, and central adiposity was defined as waist circumference >80 cm. A plasma folate concentration <10.5 nmol/L (measured through microbiological assay) was defined as plasma folate deficiency. Odds ratios (ORs) and 95% confidence intervals (CIs) for plasma folate deficiency were calculated using a logistic regression model, with adjustment for potential confounders.ResultsA total of 3,076 women of reproductive age were included in the final analysis. Compared to women with normal BMI and WC, women with both general and central adiposity had the highest odds for plasma folate deficiency (OR = 3.107, 95% CI: 1.819–5.307). Women with exclusively central adiposity had excess odds for plasma folate deficiency (WC > 80 cm, BMI <24 kg/m2; OR = 2.448, 95% CI: 1.144–5.241), which was higher than women with exclusively general adiposity (BMI ≥ 24 kg/m2, WC ≤ 80 cm; OR = 1.709, 95% CI: 1.259–2.319). The combined use of BMI and WC can detect more women (11.7%) at higher plasma folate deficiency odds than either used alone.ConclusionsWomen with central adiposity in normal weight have higher odds for plasma folate deficiency than those with general obesity only. Early screening for central adiposity among women of reproductive age would be meaningful to prevent folate deficiency and improve life-cycle health.https://www.frontiersin.org/articles/10.3389/fpubh.2022.1000542/fullfolate deficiencycentral adipositywaist circumferencebody mass indexgeneral adiposity |
| spellingShingle | Jinjuan Zhang Jinjuan Zhang Jinjuan Zhang Yushan Du Yushan Du Xiaoyu Che Xiaoyu Che Shuangbo Xia Shuangbo Xia Le Zhang Le Zhang Jufen Liu Jufen Liu Central adiposity increases the odds for plasma folate deficiency among Chinese women of reproductive age Frontiers in Public Health folate deficiency central adiposity waist circumference body mass index general adiposity |
| title | Central adiposity increases the odds for plasma folate deficiency among Chinese women of reproductive age |
| title_full | Central adiposity increases the odds for plasma folate deficiency among Chinese women of reproductive age |
| title_fullStr | Central adiposity increases the odds for plasma folate deficiency among Chinese women of reproductive age |
| title_full_unstemmed | Central adiposity increases the odds for plasma folate deficiency among Chinese women of reproductive age |
| title_short | Central adiposity increases the odds for plasma folate deficiency among Chinese women of reproductive age |
| title_sort | central adiposity increases the odds for plasma folate deficiency among chinese women of reproductive age |
| topic | folate deficiency central adiposity waist circumference body mass index general adiposity |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2022.1000542/full |
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