Effects of Lactoferrin on Oral and Throat Conditions under Low Humidity Environments: A Randomized, Double-Blind, and Placebo-Controlled Crossover Trial
To evaluate the effects of a single ingestion of bovine lactoferrin (bLF) on oral and throat conditions under a low-humidity environment. A randomized, double-blind, 2-sequence, 2-treatment, and 2-period placebo-controlled crossover trial was conducted. Healthy adult subjects orally ingested bLF dis...
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MDPI AG
2023-09-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/15/18/4033 |
| _version_ | 1797578285190742016 |
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| author | Shutaro Kubo Hirotsugu Oda Miyuki Tanaka Takashi Koikeda Shinichi Tomita |
| author_facet | Shutaro Kubo Hirotsugu Oda Miyuki Tanaka Takashi Koikeda Shinichi Tomita |
| author_sort | Shutaro Kubo |
| collection | DOAJ |
| description | To evaluate the effects of a single ingestion of bovine lactoferrin (bLF) on oral and throat conditions under a low-humidity environment. A randomized, double-blind, 2-sequence, 2-treatment, and 2-period placebo-controlled crossover trial was conducted. Healthy adult subjects orally ingested bLF dissolved in water, or placebo water, followed by exposure to low humidity (20 °C, 20% relative humidity (RH)) for 2 h. The primary endpoint was subjective oral and throat discomfort assessed by a visual analog scale (VAS), which positively correlated with the discomfort. Secondary endpoints were unstimulated whole salivary flow rate (UWSFR) and salivary immunoglobulin A (IgA) secretion rate. Overall, 40 subjects were randomly assigned to two sequences (20 each) and 34 were analyzed. The VAS values for oral and throat discomfort in the bLF treatment were significantly lower than in the placebo treatment, whereas UWSFR and IgA secretion rates were comparable between the two treatments. Adverse drug reactions were not observed. Subjective oral and throat discomfort associated with low humidity is suppressed by a single ingestion of bLF. Our findings demonstrate the novel use of bLF in a clinical situation that leverages its unique characteristics. |
| first_indexed | 2024-03-10T22:19:45Z |
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| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T22:19:45Z |
| publishDate | 2023-09-01 |
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| series | Nutrients |
| spelling | doaj.art-d66e44eee7f54eecb06c3ad4685c4a5e2023-11-19T12:19:25ZengMDPI AGNutrients2072-66432023-09-011518403310.3390/nu15184033Effects of Lactoferrin on Oral and Throat Conditions under Low Humidity Environments: A Randomized, Double-Blind, and Placebo-Controlled Crossover TrialShutaro Kubo0Hirotsugu Oda1Miyuki Tanaka2Takashi Koikeda3Shinichi Tomita4Innovative Research Institute, R&D Division, Morinaga Milk Industry Co., Ltd., 5-1-83 Higashihara, Zama 252-8583, JapanInnovative Research Institute, R&D Division, Morinaga Milk Industry Co., Ltd., 5-1-83 Higashihara, Zama 252-8583, JapanInnovative Research Institute, R&D Division, Morinaga Milk Industry Co., Ltd., 5-1-83 Higashihara, Zama 252-8583, JapanShiba Palace Clinic, Daiwa A Hamamatsucho Bldg. 6F, 1-9-10 Hamamatsucho, Minato 105-0013, JapanDepartment of Advanced Food Sciences, Faculty of Agriculture, Tamagawa University, 6-1-1 Tamagawa-Gakuen, Machida 194-8610, JapanTo evaluate the effects of a single ingestion of bovine lactoferrin (bLF) on oral and throat conditions under a low-humidity environment. A randomized, double-blind, 2-sequence, 2-treatment, and 2-period placebo-controlled crossover trial was conducted. Healthy adult subjects orally ingested bLF dissolved in water, or placebo water, followed by exposure to low humidity (20 °C, 20% relative humidity (RH)) for 2 h. The primary endpoint was subjective oral and throat discomfort assessed by a visual analog scale (VAS), which positively correlated with the discomfort. Secondary endpoints were unstimulated whole salivary flow rate (UWSFR) and salivary immunoglobulin A (IgA) secretion rate. Overall, 40 subjects were randomly assigned to two sequences (20 each) and 34 were analyzed. The VAS values for oral and throat discomfort in the bLF treatment were significantly lower than in the placebo treatment, whereas UWSFR and IgA secretion rates were comparable between the two treatments. Adverse drug reactions were not observed. Subjective oral and throat discomfort associated with low humidity is suppressed by a single ingestion of bLF. Our findings demonstrate the novel use of bLF in a clinical situation that leverages its unique characteristics.https://www.mdpi.com/2072-6643/15/18/4033lactoferrinlow humiditythroat discomfortoral discomforthealthy adult |
| spellingShingle | Shutaro Kubo Hirotsugu Oda Miyuki Tanaka Takashi Koikeda Shinichi Tomita Effects of Lactoferrin on Oral and Throat Conditions under Low Humidity Environments: A Randomized, Double-Blind, and Placebo-Controlled Crossover Trial Nutrients lactoferrin low humidity throat discomfort oral discomfort healthy adult |
| title | Effects of Lactoferrin on Oral and Throat Conditions under Low Humidity Environments: A Randomized, Double-Blind, and Placebo-Controlled Crossover Trial |
| title_full | Effects of Lactoferrin on Oral and Throat Conditions under Low Humidity Environments: A Randomized, Double-Blind, and Placebo-Controlled Crossover Trial |
| title_fullStr | Effects of Lactoferrin on Oral and Throat Conditions under Low Humidity Environments: A Randomized, Double-Blind, and Placebo-Controlled Crossover Trial |
| title_full_unstemmed | Effects of Lactoferrin on Oral and Throat Conditions under Low Humidity Environments: A Randomized, Double-Blind, and Placebo-Controlled Crossover Trial |
| title_short | Effects of Lactoferrin on Oral and Throat Conditions under Low Humidity Environments: A Randomized, Double-Blind, and Placebo-Controlled Crossover Trial |
| title_sort | effects of lactoferrin on oral and throat conditions under low humidity environments a randomized double blind and placebo controlled crossover trial |
| topic | lactoferrin low humidity throat discomfort oral discomfort healthy adult |
| url | https://www.mdpi.com/2072-6643/15/18/4033 |
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