Case Report: Sequential Development of Three Mature Lymphoid Neoplasms in a Single Patient: Clonal Relationship and Molecular Insights

Case Report: Sequential Development of Three Mature Lymphoid Neoplasms in a Single Patient: Clonal Relationship and Molecular Insights

Two main variants of Richter syndrome (RS) are recognized, namely, the diffuse large B-cell lymphoma (DLBCL) and the Hodgkin’s lymphoma (HL) variant. Clonal relationship, defined as an identity of the immunoglobulin heavy chain variable (IGHV) region sequence between chronic lymphocytic leukemia (CL...

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Bibliographic Details
Main Authors: Chiara Salvetti, Candida Vitale, Valentina Griggio, Daniela Drandi, Rebecca Jones, Lisa Bonello, Riccardo Bomben, Alberto Bragoni, Davide Bagnara, Franco Fais, Valter Gattei, Federica Cavallo, Alberto Zamò, Marta Coscia
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Oncology
Subjects:
Richter’s syndrome
chronic lymphocytic leukemia
monoclonal B-cell lymphocytosis
IGHV genes
Hodgkin lymphoma
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.917115/full

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