Gastric Signet Ring Cell Carcinoma: A Comparative Analysis of Clinicopathologic Features
Signet ring cell carcinoma (SRC) is a distinct histological subtype of gastric carcinoma. Our aim is to investigate differential characteristics between gastric SRC and other non SRC carcinomas (nSRC). It was a retrospective study including 183 patients diagnosed with gastric carcinoma over a period...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2020-11-01
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| Series: | Cancer Control |
| Online Access: | https://doi.org/10.1177/1073274820976596 |
| _version_ | 1797772263981842432 |
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| author | Boubacar Efared MD Mohamed Kadi MD Laila Tahiri MD Nada Lahmidani MD Karim Ibn Majdoub Hassani MD Hicham El Bouhaddouti MD Zineb Benbrahim MD Ibrahimi Sidi Adil MD Laila Chbani MD |
| author_facet | Boubacar Efared MD Mohamed Kadi MD Laila Tahiri MD Nada Lahmidani MD Karim Ibn Majdoub Hassani MD Hicham El Bouhaddouti MD Zineb Benbrahim MD Ibrahimi Sidi Adil MD Laila Chbani MD |
| author_sort | Boubacar Efared MD |
| collection | DOAJ |
| description | Signet ring cell carcinoma (SRC) is a distinct histological subtype of gastric carcinoma. Our aim is to investigate differential characteristics between gastric SRC and other non SRC carcinomas (nSRC). It was a retrospective study including 183 patients diagnosed with gastric carcinoma over a period of 5 years at our pathology department. We performed statistical comparison of clinicopathological features between patients with SRC and those with nSRC. 127 patients (69.4%) had nSRC, 56 had SRC (30.6%), the mean age was 56.67 ± 14.03 years. Patients with SRC were younger than those with nSRC (mean age of 49.66 versus 59.76, P = 0.030). Patients with SRC tend to have more diffuse tumors in the stomach ( P = 0.005), with flat macroscopic appearance ( P = 0.001). Patients with SRC present more often with pT3 tumors ( P < 0.001), lymph node metastasis ( P = 0.024) and perineural invasion ( P = 0.003). There were no significant differences between SRC and nSRC in gender, vascular invasion or distant metastasis ( P > 0.05). The median survival time was 42.82 ± 1.70 months. Patients with nSRC live longer than those with SRC, but the difference was not significant ( P = 0.28). SRC is a histological subtype of gastric carcinoma with distinctive clinicopathologic features. The clinical management of patients should take into account these particular features. |
| first_indexed | 2024-03-12T21:48:39Z |
| format | Article |
| id | doaj.art-d671e8269d304a4da6a2221467f04e30 |
| institution | Directory Open Access Journal |
| issn | 1073-2748 |
| language | English |
| last_indexed | 2024-03-12T21:48:39Z |
| publishDate | 2020-11-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Cancer Control |
| spelling | doaj.art-d671e8269d304a4da6a2221467f04e302023-07-26T07:05:46ZengSAGE PublishingCancer Control1073-27482020-11-012710.1177/1073274820976596Gastric Signet Ring Cell Carcinoma: A Comparative Analysis of Clinicopathologic FeaturesBoubacar Efared MD0Mohamed Kadi MD1Laila Tahiri MD2Nada Lahmidani MD3Karim Ibn Majdoub Hassani MD4Hicham El Bouhaddouti MD5Zineb Benbrahim MD6Ibrahimi Sidi Adil MD7Laila Chbani MD8 Laboratory of Pathology, Faculty of Medicine, Abdou Moumouni University, Niamey, Niger Department of Pathology, Hassan II University Hospital, Fès, Morocco Laboratory of Biomedical and Translational Research, Faculty of Medicine and Pharmacology, Sidi Mohamed Ben Abdallah University, Fès, Morocco Department of Hepatogastroenterology, Hassan II University Hospital, Sidi Mohamed Ben Abdallah University, Fès, Morocco Department of General and Visceral Surgery, Hassan II University Hospital, Sidi Mohamed Ben Abdallah University, Fès, Morocco Department of General and Visceral Surgery, Hassan II University Hospital, Sidi Mohamed Ben Abdallah University, Fès, Morocco Department of Oncology, Hassan II University Hospital, Sidi Mohamed Ben Abdallah University, Fès, Morocco Department of Hepatogastroenterology, Hassan II University Hospital, Sidi Mohamed Ben Abdallah University, Fès, Morocco Laboratory of Biomedical and Translational Research, Faculty of Medicine and Pharmacology, Sidi Mohamed Ben Abdallah University, Fès, MoroccoSignet ring cell carcinoma (SRC) is a distinct histological subtype of gastric carcinoma. Our aim is to investigate differential characteristics between gastric SRC and other non SRC carcinomas (nSRC). It was a retrospective study including 183 patients diagnosed with gastric carcinoma over a period of 5 years at our pathology department. We performed statistical comparison of clinicopathological features between patients with SRC and those with nSRC. 127 patients (69.4%) had nSRC, 56 had SRC (30.6%), the mean age was 56.67 ± 14.03 years. Patients with SRC were younger than those with nSRC (mean age of 49.66 versus 59.76, P = 0.030). Patients with SRC tend to have more diffuse tumors in the stomach ( P = 0.005), with flat macroscopic appearance ( P = 0.001). Patients with SRC present more often with pT3 tumors ( P < 0.001), lymph node metastasis ( P = 0.024) and perineural invasion ( P = 0.003). There were no significant differences between SRC and nSRC in gender, vascular invasion or distant metastasis ( P > 0.05). The median survival time was 42.82 ± 1.70 months. Patients with nSRC live longer than those with SRC, but the difference was not significant ( P = 0.28). SRC is a histological subtype of gastric carcinoma with distinctive clinicopathologic features. The clinical management of patients should take into account these particular features.https://doi.org/10.1177/1073274820976596 |
| spellingShingle | Boubacar Efared MD Mohamed Kadi MD Laila Tahiri MD Nada Lahmidani MD Karim Ibn Majdoub Hassani MD Hicham El Bouhaddouti MD Zineb Benbrahim MD Ibrahimi Sidi Adil MD Laila Chbani MD Gastric Signet Ring Cell Carcinoma: A Comparative Analysis of Clinicopathologic Features Cancer Control |
| title | Gastric Signet Ring Cell Carcinoma: A Comparative Analysis of Clinicopathologic Features |
| title_full | Gastric Signet Ring Cell Carcinoma: A Comparative Analysis of Clinicopathologic Features |
| title_fullStr | Gastric Signet Ring Cell Carcinoma: A Comparative Analysis of Clinicopathologic Features |
| title_full_unstemmed | Gastric Signet Ring Cell Carcinoma: A Comparative Analysis of Clinicopathologic Features |
| title_short | Gastric Signet Ring Cell Carcinoma: A Comparative Analysis of Clinicopathologic Features |
| title_sort | gastric signet ring cell carcinoma a comparative analysis of clinicopathologic features |
| url | https://doi.org/10.1177/1073274820976596 |
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