Evaluation of Symmetric Dimethylarginine (SDMA) in Dogs with Acute Pancreatitis
Symmetric dimethylarginine (SDMA) is considered an important biomarker of kidney dysfunction. The aims of the study were to evaluate SDMA in dogs with acute pancreatitis (AP) and its relationship with the presence of kidney injury and mortality. A cohort study including fifty-four dogs with AP diagn...
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| Format: | Article |
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MDPI AG
2020-06-01
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| Series: | Veterinary Sciences |
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| Online Access: | https://www.mdpi.com/2306-7381/7/2/72 |
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| author | Eleonora Gori Alessio Pierini Ilaria Lippi Valentina Meucci Francesca Perondi Veronica Marchetti |
| author_facet | Eleonora Gori Alessio Pierini Ilaria Lippi Valentina Meucci Francesca Perondi Veronica Marchetti |
| author_sort | Eleonora Gori |
| collection | DOAJ |
| description | Symmetric dimethylarginine (SDMA) is considered an important biomarker of kidney dysfunction. The aims of the study were to evaluate SDMA in dogs with acute pancreatitis (AP) and its relationship with the presence of kidney injury and mortality. A cohort study including fifty-four dogs with AP diagnosed using compatible clinical and laboratory parameters, abnormal SNAP cPL and compatible abdominal ultrasound within 48 h from admission, was conducted. Dogs with history of renal and/or urinary diseases were excluded, along with dogs exposed to nephrotoxic drugs. Serum urea and creatinine and urinary output (UO) were recorded. Acute kidney injury (AKI) was diagnosed and graded using International Renal Interest Society (IRIS) guidelines. SDMA was measured using high performance liquid chromatography. Fifty-four dogs were included and divided in non-AKI (<i>n</i> = 37) and AKI dogs (<i>n</i> = 17). Twenty-three dogs (14 non-AKI) had SDMA > 15 μg/dL. Median SDMA was higher in AKI dogs than non-AKI dogs (25.7 vs. 13.93 μg/dL; <i>p</i> = 0.03). Dogs with normal creatinine (AP and AKI 1 dogs) had SDMA above reference range in 38% and 33% of cases, respectively. In AKI dogs, SDMA and creatinine were positively correlated (<i>p</i> = 0.006 <i>r</i> = 0.7). SDMA was not significantly different between survivors and non-survivors. Although further studies are warranted, SDMA may be a useful tool in canine AP, as a high SDMA may be related to subclinical kidney impairment. |
| first_indexed | 2024-03-10T19:27:10Z |
| format | Article |
| id | doaj.art-d672009c1ea14aeab77d7ef0990ec938 |
| institution | Directory Open Access Journal |
| issn | 2306-7381 |
| language | English |
| last_indexed | 2024-03-10T19:27:10Z |
| publishDate | 2020-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Veterinary Sciences |
| spelling | doaj.art-d672009c1ea14aeab77d7ef0990ec9382023-11-20T02:27:26ZengMDPI AGVeterinary Sciences2306-73812020-06-01727210.3390/vetsci7020072Evaluation of Symmetric Dimethylarginine (SDMA) in Dogs with Acute PancreatitisEleonora Gori0Alessio Pierini1Ilaria Lippi2Valentina Meucci3Francesca Perondi4Veronica Marchetti5Department of Veterinary Sciences, University of Pisa, Via Livornese Lato Monte, 56121 Pisa, ItalyDepartment of Veterinary Sciences, University of Pisa, Via Livornese Lato Monte, 56121 Pisa, ItalyDepartment of Veterinary Sciences, University of Pisa, Via Livornese Lato Monte, 56121 Pisa, ItalyDepartment of Veterinary Sciences, University of Pisa, Via Livornese Lato Monte, 56121 Pisa, ItalyDepartment of Veterinary Sciences, University of Pisa, Via Livornese Lato Monte, 56121 Pisa, ItalyDepartment of Veterinary Sciences, University of Pisa, Via Livornese Lato Monte, 56121 Pisa, ItalySymmetric dimethylarginine (SDMA) is considered an important biomarker of kidney dysfunction. The aims of the study were to evaluate SDMA in dogs with acute pancreatitis (AP) and its relationship with the presence of kidney injury and mortality. A cohort study including fifty-four dogs with AP diagnosed using compatible clinical and laboratory parameters, abnormal SNAP cPL and compatible abdominal ultrasound within 48 h from admission, was conducted. Dogs with history of renal and/or urinary diseases were excluded, along with dogs exposed to nephrotoxic drugs. Serum urea and creatinine and urinary output (UO) were recorded. Acute kidney injury (AKI) was diagnosed and graded using International Renal Interest Society (IRIS) guidelines. SDMA was measured using high performance liquid chromatography. Fifty-four dogs were included and divided in non-AKI (<i>n</i> = 37) and AKI dogs (<i>n</i> = 17). Twenty-three dogs (14 non-AKI) had SDMA > 15 μg/dL. Median SDMA was higher in AKI dogs than non-AKI dogs (25.7 vs. 13.93 μg/dL; <i>p</i> = 0.03). Dogs with normal creatinine (AP and AKI 1 dogs) had SDMA above reference range in 38% and 33% of cases, respectively. In AKI dogs, SDMA and creatinine were positively correlated (<i>p</i> = 0.006 <i>r</i> = 0.7). SDMA was not significantly different between survivors and non-survivors. Although further studies are warranted, SDMA may be a useful tool in canine AP, as a high SDMA may be related to subclinical kidney impairment.https://www.mdpi.com/2306-7381/7/2/72caninepancreasinflammationkidney injury |
| spellingShingle | Eleonora Gori Alessio Pierini Ilaria Lippi Valentina Meucci Francesca Perondi Veronica Marchetti Evaluation of Symmetric Dimethylarginine (SDMA) in Dogs with Acute Pancreatitis Veterinary Sciences canine pancreas inflammation kidney injury |
| title | Evaluation of Symmetric Dimethylarginine (SDMA) in Dogs with Acute Pancreatitis |
| title_full | Evaluation of Symmetric Dimethylarginine (SDMA) in Dogs with Acute Pancreatitis |
| title_fullStr | Evaluation of Symmetric Dimethylarginine (SDMA) in Dogs with Acute Pancreatitis |
| title_full_unstemmed | Evaluation of Symmetric Dimethylarginine (SDMA) in Dogs with Acute Pancreatitis |
| title_short | Evaluation of Symmetric Dimethylarginine (SDMA) in Dogs with Acute Pancreatitis |
| title_sort | evaluation of symmetric dimethylarginine sdma in dogs with acute pancreatitis |
| topic | canine pancreas inflammation kidney injury |
| url | https://www.mdpi.com/2306-7381/7/2/72 |
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