Human Adenovirus Gene Expression and Replication Is Regulated through Dynamic Changes in Nucleoprotein Structure throughout Infection
Human adenovirus (HAdV) is extremely common and can rapidly spread in confined populations such as daycare centers, hospitals, and retirement homes. Although HAdV usually causes only minor illness in otherwise healthy patients, HAdV can cause significant morbidity and mortality in certain population...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/15/1/161 |
| _version_ | 1827621367038607360 |
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| author | Morgan R. Jennings Robin J. Parks |
| author_facet | Morgan R. Jennings Robin J. Parks |
| author_sort | Morgan R. Jennings |
| collection | DOAJ |
| description | Human adenovirus (HAdV) is extremely common and can rapidly spread in confined populations such as daycare centers, hospitals, and retirement homes. Although HAdV usually causes only minor illness in otherwise healthy patients, HAdV can cause significant morbidity and mortality in certain populations, such as the very young, very old, or immunocompromised individuals. During infection, the viral DNA undergoes dramatic changes in nucleoprotein structure that promote the rapid expression of viral genes, replication of the DNA, and generation of thousands of new infectious virions—each process requiring a distinct complement of virus and host-encoded proteins. In this review, we summarize our current understanding of the nucleoprotein structure of HAdV DNA during the various phases of infection, the cellular proteins implicated in mediating these changes, and the role of epigenetics in HAdV gene expression and replication. |
| first_indexed | 2024-03-09T11:02:36Z |
| format | Article |
| id | doaj.art-d67363b5409f4b828fe558b64a4bd387 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-09T11:02:36Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-d67363b5409f4b828fe558b64a4bd3872023-12-01T01:11:40ZengMDPI AGViruses1999-49152023-01-0115116110.3390/v15010161Human Adenovirus Gene Expression and Replication Is Regulated through Dynamic Changes in Nucleoprotein Structure throughout InfectionMorgan R. Jennings0Robin J. Parks1Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, CanadaRegenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, CanadaHuman adenovirus (HAdV) is extremely common and can rapidly spread in confined populations such as daycare centers, hospitals, and retirement homes. Although HAdV usually causes only minor illness in otherwise healthy patients, HAdV can cause significant morbidity and mortality in certain populations, such as the very young, very old, or immunocompromised individuals. During infection, the viral DNA undergoes dramatic changes in nucleoprotein structure that promote the rapid expression of viral genes, replication of the DNA, and generation of thousands of new infectious virions—each process requiring a distinct complement of virus and host-encoded proteins. In this review, we summarize our current understanding of the nucleoprotein structure of HAdV DNA during the various phases of infection, the cellular proteins implicated in mediating these changes, and the role of epigenetics in HAdV gene expression and replication.https://www.mdpi.com/1999-4915/15/1/161adenovirusepigeneticsnucleoproteinnucleoprotein remodelingviral replicationepigenetic modulators |
| spellingShingle | Morgan R. Jennings Robin J. Parks Human Adenovirus Gene Expression and Replication Is Regulated through Dynamic Changes in Nucleoprotein Structure throughout Infection Viruses adenovirus epigenetics nucleoprotein nucleoprotein remodeling viral replication epigenetic modulators |
| title | Human Adenovirus Gene Expression and Replication Is Regulated through Dynamic Changes in Nucleoprotein Structure throughout Infection |
| title_full | Human Adenovirus Gene Expression and Replication Is Regulated through Dynamic Changes in Nucleoprotein Structure throughout Infection |
| title_fullStr | Human Adenovirus Gene Expression and Replication Is Regulated through Dynamic Changes in Nucleoprotein Structure throughout Infection |
| title_full_unstemmed | Human Adenovirus Gene Expression and Replication Is Regulated through Dynamic Changes in Nucleoprotein Structure throughout Infection |
| title_short | Human Adenovirus Gene Expression and Replication Is Regulated through Dynamic Changes in Nucleoprotein Structure throughout Infection |
| title_sort | human adenovirus gene expression and replication is regulated through dynamic changes in nucleoprotein structure throughout infection |
| topic | adenovirus epigenetics nucleoprotein nucleoprotein remodeling viral replication epigenetic modulators |
| url | https://www.mdpi.com/1999-4915/15/1/161 |
| work_keys_str_mv | AT morganrjennings humanadenovirusgeneexpressionandreplicationisregulatedthroughdynamicchangesinnucleoproteinstructurethroughoutinfection AT robinjparks humanadenovirusgeneexpressionandreplicationisregulatedthroughdynamicchangesinnucleoproteinstructurethroughoutinfection |