Zi Shen Huo Luo Formula Enhances the Therapeutic Effects of Angiotensin-Converting Enzyme Inhibitors on Hypertensive Left Ventricular Hypertrophy by Interfering With Aldosterone Breakthrough and Affecting Caveolin-1/Mineralocorticoid Receptor Colocalization and Downstream Extracellular Signal-Regulated Kinase Signaling

Zi Shen Huo Luo Formula Enhances the Therapeutic Effects of Angiotensin-Converting Enzyme Inhibitors on Hypertensive Left Ventricular Hypertrophy by Interfering With Aldosterone Breakthrough and Affecting Caveolin-1/Mineralocorticoid Receptor Colocalization and Downstream Extracellular Signal-Regulated Kinase Signaling

Left ventricular hypertrophy (LVH) is an important characteristic of hypertensive heart disease. Renin-angiotensin system (RAS) blockers have been shown to be effective drugs for the reversal of LVH. Clinical and experimental studies have shown that Zi Shen Huo Luo Formula (ZSHLF) can improve the ef...

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Bibliographic Details
Main Authors: Xiaotong Song, Yue Zhao, Shijun Wang, Yuan Wang, Qian Chen, Haijun Zhao, Hua Wang, Sheng Tian, Huayun Yu, Zhichun Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Pharmacology
Subjects:
hypertension
left ventricular hypertrophy
aldosterone breakthrough
Zi Shen Huo Luo formula
mineralocorticoid receptor
EGFR signaling pathway
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00383/full

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