Tiny but mighty: Possible roles of bacterial extracellular vesicles in gut‐liver crosstalk for non‐alcoholic fatty liver disease
Abstract Non‐alcoholic fatty liver disease (NAFLD) with an increasing incidence is one of the leading causes for liver transplantation and cancer, whereas understandings on the onset and development of this disease are quite limited. Nowadays, gut microbial dysregulation has been proposed to play a...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-09-01
|
| Series: | Clinical and Translational Discovery |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/ctd2.115 |
| _version_ | 1811190681187647488 |
|---|---|
| author | Li Shao Junping Shi Xiaohui Fan |
| author_facet | Li Shao Junping Shi Xiaohui Fan |
| author_sort | Li Shao |
| collection | DOAJ |
| description | Abstract Non‐alcoholic fatty liver disease (NAFLD) with an increasing incidence is one of the leading causes for liver transplantation and cancer, whereas understandings on the onset and development of this disease are quite limited. Nowadays, gut microbial dysregulation has been proposed to play a critical role in the immune‐metabolic disorders in NAFLD patients via gut‐liver axis. Although definitive crosstalk between gut and liver has not been thoroughly depicted, the nanosized bacterial extracellular vesicles (bEVs) capable of transporting multiple kinds of molecules to distant organs of host in intact form via system circulation act as major mediators in host‐bacterial interactions. A recent review has confirmed the associations between bEVs and NAFLD features such as insulin resistance and liver inflammation, whereas the mechanisms involved have not been elucidated. Considering that gut‐liver crosstalk is the main pathway through which bEVs take part in NAFLD pathogenesis, we summarize the recent findings of bEVs in gut‐liver crosstalk by modulating the reshape of gut microbial system, host intestinal barrier integrity, host immune responses and metabolic homeostasis, as well as the potential roles of bEVs in regulating NAFLD progression. |
| first_indexed | 2024-04-11T14:54:19Z |
| format | Article |
| id | doaj.art-d674f9313e694b80a3b499d22a3917e1 |
| institution | Directory Open Access Journal |
| issn | 2768-0622 |
| language | English |
| last_indexed | 2024-04-11T14:54:19Z |
| publishDate | 2022-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Translational Discovery |
| spelling | doaj.art-d674f9313e694b80a3b499d22a3917e12022-12-22T04:17:19ZengWileyClinical and Translational Discovery2768-06222022-09-0123n/an/a10.1002/ctd2.115Tiny but mighty: Possible roles of bacterial extracellular vesicles in gut‐liver crosstalk for non‐alcoholic fatty liver diseaseLi Shao0Junping Shi1Xiaohui Fan2School of Clinical Medicine, Hangzhou Normal University The Affiliated Hospital of Hangzhou Normal University Hangzhou ChinaDepartment of Hepatology The Affiliated Hospital of Hangzhou Normal University Hangzhou ChinaPharmaceutical Informatics Institute, College of Pharmaceutical Sciences Zhejiang University Hangzhou ChinaAbstract Non‐alcoholic fatty liver disease (NAFLD) with an increasing incidence is one of the leading causes for liver transplantation and cancer, whereas understandings on the onset and development of this disease are quite limited. Nowadays, gut microbial dysregulation has been proposed to play a critical role in the immune‐metabolic disorders in NAFLD patients via gut‐liver axis. Although definitive crosstalk between gut and liver has not been thoroughly depicted, the nanosized bacterial extracellular vesicles (bEVs) capable of transporting multiple kinds of molecules to distant organs of host in intact form via system circulation act as major mediators in host‐bacterial interactions. A recent review has confirmed the associations between bEVs and NAFLD features such as insulin resistance and liver inflammation, whereas the mechanisms involved have not been elucidated. Considering that gut‐liver crosstalk is the main pathway through which bEVs take part in NAFLD pathogenesis, we summarize the recent findings of bEVs in gut‐liver crosstalk by modulating the reshape of gut microbial system, host intestinal barrier integrity, host immune responses and metabolic homeostasis, as well as the potential roles of bEVs in regulating NAFLD progression.https://doi.org/10.1002/ctd2.115bacterial extracellular vesiclegut‐liver axisNAFLD |
| spellingShingle | Li Shao Junping Shi Xiaohui Fan Tiny but mighty: Possible roles of bacterial extracellular vesicles in gut‐liver crosstalk for non‐alcoholic fatty liver disease Clinical and Translational Discovery bacterial extracellular vesicle gut‐liver axis NAFLD |
| title | Tiny but mighty: Possible roles of bacterial extracellular vesicles in gut‐liver crosstalk for non‐alcoholic fatty liver disease |
| title_full | Tiny but mighty: Possible roles of bacterial extracellular vesicles in gut‐liver crosstalk for non‐alcoholic fatty liver disease |
| title_fullStr | Tiny but mighty: Possible roles of bacterial extracellular vesicles in gut‐liver crosstalk for non‐alcoholic fatty liver disease |
| title_full_unstemmed | Tiny but mighty: Possible roles of bacterial extracellular vesicles in gut‐liver crosstalk for non‐alcoholic fatty liver disease |
| title_short | Tiny but mighty: Possible roles of bacterial extracellular vesicles in gut‐liver crosstalk for non‐alcoholic fatty liver disease |
| title_sort | tiny but mighty possible roles of bacterial extracellular vesicles in gut liver crosstalk for non alcoholic fatty liver disease |
| topic | bacterial extracellular vesicle gut‐liver axis NAFLD |
| url | https://doi.org/10.1002/ctd2.115 |
| work_keys_str_mv | AT lishao tinybutmightypossiblerolesofbacterialextracellularvesiclesingutlivercrosstalkfornonalcoholicfattyliverdisease AT junpingshi tinybutmightypossiblerolesofbacterialextracellularvesiclesingutlivercrosstalkfornonalcoholicfattyliverdisease AT xiaohuifan tinybutmightypossiblerolesofbacterialextracellularvesiclesingutlivercrosstalkfornonalcoholicfattyliverdisease |