Alpha1-Adrenergic Receptor Mediated Long-Term Depression at CA3-CA1 Synapses Can Be Induced via Accumulation of Endogenous Norepinephrine and Is Preserved Following Noradrenergic Denervation

Alpha1-Adrenergic Receptor Mediated Long-Term Depression at CA3-CA1 Synapses Can Be Induced via Accumulation of Endogenous Norepinephrine and Is Preserved Following Noradrenergic Denervation

Locus coeruleus (LC) provides the sole source of noradrenergic (NA) innervation to hippocampus, and it undergoes significant degeneration early in Alzheimer’s disease (AD). Norepinephrine (NE) modulates synaptic transmission and plasticity at hippocampal synapses which likely contributes to hippocam...

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Bibliographic Details
Main Authors: Katie Dyer-Reaves, Anthoni M. Goodman, Amy R. Nelson, Lori L. McMahon
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Synaptic Neuroscience
Subjects:
hippocampus
norepinephrine
LTD
α1-AR
locus coeruleus
Online Access:https://www.frontiersin.org/article/10.3389/fnsyn.2019.00027/full

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