Interdisciplinary Study of the Effects of Dipeptidyl-Peptidase III Cancer Mutations on the KEAP1-NRF2 Signaling Pathway

Interdisciplinary Study of the Effects of Dipeptidyl-Peptidase III Cancer Mutations on the KEAP1-NRF2 Signaling Pathway

Dipeptidyl peptidase III (DPP III) is associated with cancer progression via interaction with KEAP1, leading to upregulation of the KEAP1-NRF2 oxidative stress pathway. Numerous DPP III mutations have been found in human tumor genomes, and it is suggested that some of them may alter affinity for KEA...

Full description

Bibliographic Details
Main Authors: Sara Matić, Ana Tomašić Paić, Sandra Sobočanec, Marija Pinterić, Goran Pipalović, Monika Martinčić, Mihaela Matovina, Sanja Tomić
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:International Journal of Molecular Sciences
Subjects:
DPP III
KEAP1-NRF2 pathway
oxidative stress
cancer mutation
protein interaction
Online Access:https://www.mdpi.com/1422-0067/23/4/1994

Similar Items

Similar Items