Dental-Pulp Stem Cells as a Therapeutic Strategy for Ischemic Stroke
Regenerative medicine aims to restore human functions by regenerating organs and tissues using stem cells or living tissues for the treatment of organ and tissue defects or dysfunction. Clinical trials investigating the treatment of cerebral infarction using mesenchymal stem cells, a type of somatic...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/10/4/737 |
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| author | Chikako Nito Satoshi Suda Yuko Nitahara-Kasahara Takashi Okada Kazumi Kimura |
| author_facet | Chikako Nito Satoshi Suda Yuko Nitahara-Kasahara Takashi Okada Kazumi Kimura |
| author_sort | Chikako Nito |
| collection | DOAJ |
| description | Regenerative medicine aims to restore human functions by regenerating organs and tissues using stem cells or living tissues for the treatment of organ and tissue defects or dysfunction. Clinical trials investigating the treatment of cerebral infarction using mesenchymal stem cells, a type of somatic stem cell therapy, are underway. The development and production of regenerative medicines using somatic stem cells is expected to contribute to the treatment of cerebral infarction, a central nervous system disease for which there is no effective treatment. Numerous experimental studies have shown that cellular therapy, including the use of human dental pulp stem cells, is an attractive strategy for patients with ischemic brain injury. This review describes the basic research, therapeutic mechanism, clinical trials, and future prospects for dental pulp stem cell therapy, which is being investigated in Japan in first-in-human clinical trials for the treatment of patients with acute cerebral ischemia. |
| first_indexed | 2024-03-09T11:08:31Z |
| format | Article |
| id | doaj.art-d67b5d60fe7a4da28dc9ea3ffdf3f31b |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T11:08:31Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-d67b5d60fe7a4da28dc9ea3ffdf3f31b2023-12-01T00:52:34ZengMDPI AGBiomedicines2227-90592022-03-0110473710.3390/biomedicines10040737Dental-Pulp Stem Cells as a Therapeutic Strategy for Ischemic StrokeChikako Nito0Satoshi Suda1Yuko Nitahara-Kasahara2Takashi Okada3Kazumi Kimura4Department of Neurological Science, Graduate School of Medicine, Nippon Medical School, Tokyo 113-8603, JapanDepartment of Neurological Science, Graduate School of Medicine, Nippon Medical School, Tokyo 113-8603, JapanDivision of Molecular and Medical Genetics, The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, JapanDivision of Molecular and Medical Genetics, The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, JapanDepartment of Neurological Science, Graduate School of Medicine, Nippon Medical School, Tokyo 113-8603, JapanRegenerative medicine aims to restore human functions by regenerating organs and tissues using stem cells or living tissues for the treatment of organ and tissue defects or dysfunction. Clinical trials investigating the treatment of cerebral infarction using mesenchymal stem cells, a type of somatic stem cell therapy, are underway. The development and production of regenerative medicines using somatic stem cells is expected to contribute to the treatment of cerebral infarction, a central nervous system disease for which there is no effective treatment. Numerous experimental studies have shown that cellular therapy, including the use of human dental pulp stem cells, is an attractive strategy for patients with ischemic brain injury. This review describes the basic research, therapeutic mechanism, clinical trials, and future prospects for dental pulp stem cell therapy, which is being investigated in Japan in first-in-human clinical trials for the treatment of patients with acute cerebral ischemia.https://www.mdpi.com/2227-9059/10/4/737dental pulp stem cellscell-based therapyneuroprotectioncerebral ischemiaclinical trials |
| spellingShingle | Chikako Nito Satoshi Suda Yuko Nitahara-Kasahara Takashi Okada Kazumi Kimura Dental-Pulp Stem Cells as a Therapeutic Strategy for Ischemic Stroke Biomedicines dental pulp stem cells cell-based therapy neuroprotection cerebral ischemia clinical trials |
| title | Dental-Pulp Stem Cells as a Therapeutic Strategy for Ischemic Stroke |
| title_full | Dental-Pulp Stem Cells as a Therapeutic Strategy for Ischemic Stroke |
| title_fullStr | Dental-Pulp Stem Cells as a Therapeutic Strategy for Ischemic Stroke |
| title_full_unstemmed | Dental-Pulp Stem Cells as a Therapeutic Strategy for Ischemic Stroke |
| title_short | Dental-Pulp Stem Cells as a Therapeutic Strategy for Ischemic Stroke |
| title_sort | dental pulp stem cells as a therapeutic strategy for ischemic stroke |
| topic | dental pulp stem cells cell-based therapy neuroprotection cerebral ischemia clinical trials |
| url | https://www.mdpi.com/2227-9059/10/4/737 |
| work_keys_str_mv | AT chikakonito dentalpulpstemcellsasatherapeuticstrategyforischemicstroke AT satoshisuda dentalpulpstemcellsasatherapeuticstrategyforischemicstroke AT yukonitaharakasahara dentalpulpstemcellsasatherapeuticstrategyforischemicstroke AT takashiokada dentalpulpstemcellsasatherapeuticstrategyforischemicstroke AT kazumikimura dentalpulpstemcellsasatherapeuticstrategyforischemicstroke |