A new Zn(II)-coordination polymer based on m-terphenyl pentacarboxylic acid ligand for photocatalytic methylene blue degradation and protective effect against Alzheimer’s disease by reducing the inflammatory response and oxidative stress in the nerve cells
In this work, a novel two-dimensional coordination polymer was prepared via reaction of 4,4′-dipyridyl (4,4′-bipy) with Zn(NO3)2·6H2O and m-terphenyl pentacarboxylic acid (H5L) within water and DMA mixed solvent, and its chemical formula is [Zn2(HL)(4,4′-bipy)(H2O)](DMA) (1). Due to its good framewo...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-04-01
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| Series: | Arabian Journal of Chemistry |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1878535220300630 |
| _version_ | 1818905378294857728 |
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| author | Ruihua Hou Ping Han Qiang Liu Guangrun Xu Shujun Xu Teng Chen |
| author_facet | Ruihua Hou Ping Han Qiang Liu Guangrun Xu Shujun Xu Teng Chen |
| author_sort | Ruihua Hou |
| collection | DOAJ |
| description | In this work, a novel two-dimensional coordination polymer was prepared via reaction of 4,4′-dipyridyl (4,4′-bipy) with Zn(NO3)2·6H2O and m-terphenyl pentacarboxylic acid (H5L) within water and DMA mixed solvent, and its chemical formula is [Zn2(HL)(4,4′-bipy)(H2O)](DMA) (1). Due to its good framework stability in water, complex 1 was studied as a catalyst for photocatalytic degradation of methylene blue (MB) in water under the ultraviolet light. Both of the remarkable efficiency and good catalytic stability could be achieved in the complex 1. Furthermore, to evaluate the treatment activity of the compound on the Alzheimer's disease (AD), AD mice model was established and treated with the compound. And then, AD mice brain tissues were weighted and the cognitive function of AD mice was determined. Then, the content of amyloid β peptides (Aβ) in the hippocampus was measured with western blot; the inflammatory cytokines TNF-α along with IL-1β within CSF was detected via ELISA detection kit; oxidative stress level within the cells of nerve was determined via ROS test kit. CCK-8 assay was performed to detect the toxicity of the compound on normal human cells. Keywords: Coordination polymer, Zn(II)-framework, Methylene blue degradation, Alzheimer's disease |
| first_indexed | 2024-12-19T21:22:23Z |
| format | Article |
| id | doaj.art-d67bda736f64481d9c3121bf22880f23 |
| institution | Directory Open Access Journal |
| issn | 1878-5352 |
| language | English |
| last_indexed | 2024-12-19T21:22:23Z |
| publishDate | 2020-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Arabian Journal of Chemistry |
| spelling | doaj.art-d67bda736f64481d9c3121bf22880f232022-12-21T20:05:12ZengElsevierArabian Journal of Chemistry1878-53522020-04-0113451715180A new Zn(II)-coordination polymer based on m-terphenyl pentacarboxylic acid ligand for photocatalytic methylene blue degradation and protective effect against Alzheimer’s disease by reducing the inflammatory response and oxidative stress in the nerve cellsRuihua Hou0Ping Han1Qiang Liu2Guangrun Xu3Shujun Xu4Teng Chen5Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UKDepartment of Neurosurgical Intensive Care Unit/Emergency Neurosurgery, Qilu Hospital of Shandong University, Jinan, Shandong, ChinaDepartment of Neurosurgery, Qilu Hospital of Shandong University, Jinan, Shandong, ChinaDepartment of Neurosurgery, Qilu Hospital of Shandong University, Jinan, Shandong, ChinaDepartment of Neurosurgery, Qilu Hospital of Shandong University, Jinan, Shandong, ChinaDepartment of Neurosurgery, Qilu Hospital of Shandong University, Jinan, Shandong, China; Corresponding author.In this work, a novel two-dimensional coordination polymer was prepared via reaction of 4,4′-dipyridyl (4,4′-bipy) with Zn(NO3)2·6H2O and m-terphenyl pentacarboxylic acid (H5L) within water and DMA mixed solvent, and its chemical formula is [Zn2(HL)(4,4′-bipy)(H2O)](DMA) (1). Due to its good framework stability in water, complex 1 was studied as a catalyst for photocatalytic degradation of methylene blue (MB) in water under the ultraviolet light. Both of the remarkable efficiency and good catalytic stability could be achieved in the complex 1. Furthermore, to evaluate the treatment activity of the compound on the Alzheimer's disease (AD), AD mice model was established and treated with the compound. And then, AD mice brain tissues were weighted and the cognitive function of AD mice was determined. Then, the content of amyloid β peptides (Aβ) in the hippocampus was measured with western blot; the inflammatory cytokines TNF-α along with IL-1β within CSF was detected via ELISA detection kit; oxidative stress level within the cells of nerve was determined via ROS test kit. CCK-8 assay was performed to detect the toxicity of the compound on normal human cells. Keywords: Coordination polymer, Zn(II)-framework, Methylene blue degradation, Alzheimer's diseasehttp://www.sciencedirect.com/science/article/pii/S1878535220300630 |
| spellingShingle | Ruihua Hou Ping Han Qiang Liu Guangrun Xu Shujun Xu Teng Chen A new Zn(II)-coordination polymer based on m-terphenyl pentacarboxylic acid ligand for photocatalytic methylene blue degradation and protective effect against Alzheimer’s disease by reducing the inflammatory response and oxidative stress in the nerve cells Arabian Journal of Chemistry |
| title | A new Zn(II)-coordination polymer based on m-terphenyl pentacarboxylic acid ligand for photocatalytic methylene blue degradation and protective effect against Alzheimer’s disease by reducing the inflammatory response and oxidative stress in the nerve cells |
| title_full | A new Zn(II)-coordination polymer based on m-terphenyl pentacarboxylic acid ligand for photocatalytic methylene blue degradation and protective effect against Alzheimer’s disease by reducing the inflammatory response and oxidative stress in the nerve cells |
| title_fullStr | A new Zn(II)-coordination polymer based on m-terphenyl pentacarboxylic acid ligand for photocatalytic methylene blue degradation and protective effect against Alzheimer’s disease by reducing the inflammatory response and oxidative stress in the nerve cells |
| title_full_unstemmed | A new Zn(II)-coordination polymer based on m-terphenyl pentacarboxylic acid ligand for photocatalytic methylene blue degradation and protective effect against Alzheimer’s disease by reducing the inflammatory response and oxidative stress in the nerve cells |
| title_short | A new Zn(II)-coordination polymer based on m-terphenyl pentacarboxylic acid ligand for photocatalytic methylene blue degradation and protective effect against Alzheimer’s disease by reducing the inflammatory response and oxidative stress in the nerve cells |
| title_sort | new zn ii coordination polymer based on m terphenyl pentacarboxylic acid ligand for photocatalytic methylene blue degradation and protective effect against alzheimer s disease by reducing the inflammatory response and oxidative stress in the nerve cells |
| url | http://www.sciencedirect.com/science/article/pii/S1878535220300630 |
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